Organic Letters, Год журнала: 2024, Номер 26(15), С. 2987 - 2992

Опубликована: Апрель 2, 2024

A regioselective coupling of ortho-heteroaryl anilines and 7-oxabenzonorbornadienes has been developed by leveraging free amine-directed redox-neutral Ru(II) catalysis. This protocol facilitates formal C-2 arylation the indole moiety under mild conditions to offer valuable heterobiaryls in high yields. The reaction displays a broad substrate generality scalability retains efficacy presence diverse pharmacophore scaffolds. Moreover, products bearing amine group were successfully employed Mg(NTf2)2-catalyzed double Michael addition cascade, which led synthesis intricate indole- pyrrole-fused azaheterocycles.

Язык: Английский