The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

We present a new strategy for the synthesis of O-aryl glycosides through formal insertion glycosylidene carbenes into O–H bond phenols. The key carbene intermediates were generated in situ by copper-catalyzed oxidation bench-stable diaziridine precursors. This method enables glycosylation variety phenols with good yields, excellent diastereoselectivity, and chemoselectivity, providing highly practical late-stage complex natural products bioactive agents.

Язык: Английский