Trends in Chemistry,
Год журнала:
2024,
Номер
6(4), С. 173 - 185
Опубликована: Март 28, 2024
In
efforts
to
improve
the
affordability
of
drugs
in
regions
world
where
they
are
most
needed,
synthetic
sequences
described
that
apply
green
and
sustainable
technologies
partial
or
total
syntheses
several
target
molecules.
Here,
focus
is
on
routes
to:
(i)
three
antimalarial
drugs,
key
portions
thereof;
(ii)
a
targeted
polypeptide
(as
found
Paxlovid)
used
extensively
treatment
COVID-19;
(iii)
two
subsections
potent,
timely,
anti-HIV
agent.
Each
highlighted
by
its
adherence
Principles
Green
Chemistry,
leading
more
environmentally
responsible,
hence
potentially
cost-effective,
route
associated
with
their
manufacture.
Such
approaches
may
impact
health
well-being
millions,
while
dramatically
reducing
overall
environmental
impact.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 16, 2024
Readily
accessible,
racemic
N-carboxyanhydrides
(NCAs)
of
α-amino
acids
underwent
a
deracemization
reaction
upon
irradiation
at
λ=366
nm
in
the
presence
chiral
benzophenone
catalyst.
The
enantioenriched
NCAs
(up
to
98
%
ee)
serve
as
activated
acid
surrogates
and,
due
their
instability,
they
were
directly
converted
into
consecutive
products.
N-Protected
esters
obtained
after
with
MeOH
and
N-benzoylation
(14
examples,
70
%-quant.,
82-96
ee).
Other
reactions
included
amide
(ten
65
90-98
peptide
(three
75-89
%,
d.
r.=97/3
94/6)
bond
formation.
Limitations
method
relate
for
some
issues
solubility,
photooxidation,
high
configurational
lability.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(9), С. 6545 - 6554
Опубликована: Апрель 17, 2024
A
versatile
reaction
between
N-tosylhydrazones
and
carboxylic
acids
to
access
bisamides
is
reported.
This
metal-free,
room-temperature
was
catalyzed
by
TBAI,
while
TBHP
served
as
the
oxidant.
Broad
substrate
scope
good
functional
group
tolerance
are
key
features
of
strategy.
Subsequent
intramolecular
N-arylation
suitably
substituted
readily
afforded
functionalized
3-indazolones.
Angewandte Chemie,
Год журнала:
2024,
Номер
136(40)
Опубликована: Июль 2, 2024
Abstract
The
dehydrogenative
coupling
of
alcohols
and
amines
to
form
amide
bonds
is
typically
catalysed
by
homogeneous
transition
metal
catalysts
at
high
temperatures
ranging
from
130–140
°C.
In
our
pursuit
an
efficient
recyclable
photocatalyst
capable
conducting
this
transformation
room
temperature,
we
report
herein
a
COF‐mediated
synthesis.
TTT‐DHTD
COF
was
strategically
designed
incorporate
density
functional
units,
specifically
dithiophenedione,
trap
photogenerated
electrons
effectively
facilitate
hydrogen
atom
abstraction
reactions.
photoactive
COF,
synthesized
using
solvothermal
methods
showed
crystallinity
moderate
surface
area,
providing
ideal
platform
for
heterogeneous
Light
absorption
the
across
entire
visible
range,
narrow
band
gap,
valence
position
make
it
well‐suited
generation
excitons
necessary
targeted
dehydrogenation.
Utilizing
red
light
irradiation
employing
extremely
low
loading
have
successfully
prepared
wide
range
amides,
including
challenging
secondary
in
good
excellent
yields.
substrates’
group
tolerance,
very
mild
reaction
conditions,
catalyst's
significant
recyclability
represent
substantial
advancements
over
prior
methodologies.
