Synthesis of substituted 5‐aryl‐2,3‐dihydropyrazine 1,4‐dioxides based on condensation of N,N′‐(2,3‐dimethylbutane‐2,3‐diyl)bis(hydroxylamine) with various arylglyoxals

Journal of Heterocyclic Chemistry, Год журнала: 2024, Номер 61(7), С. 1057 - 1065

Опубликована: Май 8, 2024

Abstract For the first time, a method for synthesis of 2,3‐dihydropyrazine 1,4‐dioxide derivatives was devised. The presented approach is based on reaction N , ′‐(2,3‐dimethylbutane‐2,3‐diyl)bis(hydroxylamine) with α‐ketoaldehydes. A distinctive feature proposed protocol application sulfate aforementioned bis‐hydroxylamine in considered condensation. advantages newly developed route are one‐step synthetic procedure involving easily available starting materials, atom economy, and simple work‐up mixture. structure one obtained products confirmed by x‐ray analysis.

Язык: Английский

Synthesis of Quinolinoneylnitrones and Coumarinylnitrones via a Cascade Hydroamination and Aza-MBH-Type Reaction

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(14), С. 10327 - 10332

Опубликована: Июль 4, 2024

Nitrones are quite useful intermediates and have been broadly applied in organic synthesis, drug discovery, photochemistry research. Many functional nitrones successfully prepared using various strategies. In this work, an efficient method for synthesizing novel quinolinoneylnitrone coumarinylnitrone derivatives was developed. Preliminary mechanistic research suggests that protocol included a cascade hydroamination aza-MBH-type reaction.

Язык: Английский

Five-membered ring systems with O and N atoms

Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 275 - 308

Опубликована: Янв. 1, 2024

Язык: Английский