Mechanochemistry in Organic Synthesis: An Italian Journey through Innovations
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(30)
Опубликована: Май 18, 2024
Abstract
Mechanochemistry,
as
an
enabling
technology,
harnesses
mechanical
force
to
drive
chemical
reactions,
presenting
compelling
advantages
in
organic
synthesis
within
the
principles
of
green
chemistry.
This
review
explores
how
its
unique
and
alignment
with
sustainable
practices
have
been
widely
developed
different
scientific
fields
Italy.
As
a
transformative
strategy
for
synthesis,
mechanochemistry
has
portrayed
this
valuable
synthetic
alternative
due
various
advantages,
such
solvent
reduction
new
reaction
pathways,
that
use
brings.
Nonetheless,
improvements
brought
about
by
also
crucial
other
chemistry
described
Italian
scientists.
In
whole
context,
researchers
analysed
both
already
optimised
processes
feasible
paving
way
avenues
previously
hampered
all
limitations
belong
in‐solution
Язык: Английский
Unveiling the Untapped Potential of Bertagnini’s Salts in Microwave-Assisted Synthesis of Quinazolinones
Molecules,
Год журнала:
2024,
Номер
29(9), С. 1986 - 1986
Опубликована: Апрель 26, 2024
Microwave-assisted
organic
synthesis
(MAOS)
has
emerged
as
a
transformative
technique
in
chemistry,
significantly
enhancing
the
speed,
efficiency,
and
selectivity
of
chemical
reactions.
In
our
research,
we
have
employed
microwave
irradiation
to
expedite
quinazolinones,
using
water
an
eco-friendly
solvent
thereby
adhering
principles
green
chemistry.
Notably,
purification
product
was
achieved
without
need
for
column
chromatography,
thus
streamlining
process.
A
key
innovation
approach
is
aldehyde
bisulfite
adducts
(Bertagnini's
salts)
solid
surrogates
aldehydes.
Bertagnini's
salts
offer
several
advantages
over
free
aldehydes,
including
enhanced
stability,
easier
purification,
improved
reactivity.
Green
metrics
Eco-Scale
score
calculations
confirmed
sustainability
this
approach,
indicating
reduction
waste
generation
outcomes.
This
methodology
facilitates
diverse
array
compounds,
offering
substantial
contributions
field,
with
potential
widespread
applications
pharmaceutical
research
beyond.
Язык: Английский
Pioneering Metal‐Free Late‐Stage C‐H Functionalization Using Acridinium Salt Photocatalysis
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(67)
Опубликована: Авг. 13, 2024
Abstract
Using
organic
dyes
as
photocatalysts
is
an
innovative
approach
to
photocatalytic
transformations.
These
offer
advantages
such
widespread
availability,
adaptable
absorption
properties,
and
diverse
chemical
structures.
Recent
progress
has
led
the
development
of
that
can
utilize
visible
light
modify
chemically
inert
C−H
bonds.
catalysts
are
sustainable,
selective,
versatile,
enabling
mild
reactions,
late‐stage
functionalization,
various
transformations
in
line
with
green
chemistry
principles.
As
photoredox
chemistry,
they
contribute
efficient
environmentally
friendly
synthetic
pathways.
Acridinium‐based
have
proved
valuable
transformative
reactions
under
conditions.
This
review
emphasizes
their
features,
frameworks,
applications
modifying
complex
molecules.
It
provides
overview
recent
advancements
use
acridinium‐based
for
bond
functionalization
without
need
transition
metals,
showcasing
potential
expedite
new
molecules
igniting
excitement
about
prospects
this
research
field.
Язык: Английский