Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 23, 2024
A novel, mild, and environmentally friendly method was developed for the synthesis of quaternary-carbon-containing succinyldiamides. This found to be compatible with many substrates.
Язык: Английский
Organic Letters, Год журнала: 2024, Номер 26(21), С. 4526 - 4531
Опубликована: Май 18, 2024
We report a novel organic photoredox catalysis to achieve unprecedented γ-(hetero)aryl/alkenyl-δ-silyl aliphatic amines via silyl-mediated distal (hetero)aryl/alkenyl migration of aromatic/alkenyl bearing unactivated alkenes with hydrosilanes. This protocol features mild and metal-free reaction conditions, high atom economy, excellent selectivity, functional group compatibility. Mechanistic studies suggest that silylation (hetero)aryl/alkenylation involve hydrogen transfer subsequent 1,4-migration remote from nitrogen carbon.
Язык: Английский
Процитировано
6
The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 16, 2025
A photocatalytic radical sulfonarylation of N-arylacrylamides via a three-component cascade cyclopropyl alcohol ring opening/sulfur dioxide insertion/sulfonyl addition/cyclization sequence has been developed. This method employs alcohols as the precursors β-carbonyl alkyl radicals and Na2S2O5 cheap source sulfur dioxide. By using this procedure, wide variety γ-keto-sulfone-substituted oxindoles were facilely synthesized.
Язык: Английский
Процитировано
0
Organic Letters, Год журнала: 2024, Номер 26(34), С. 7170 - 7175
Опубликована: Авг. 19, 2024
A cascade reaction of cyclopropyl alcohols, DABSO (1,4-diazoniabicyclo[2.2.2]octane-1,4-disulfinate), and N-(sulfonyl)acrylamides has been developed. This tandem process went through a cyclopropanol ring opening Michael addition sequence. The γ-keto sulfinate generated from the between serves as nucleophilic reagent, N-(sulfonyl)acrylamide is used acceptor. By utilizing this strategy, multitudinous sulfone-bridged 1,7-dicarbonyl compounds that contain both β-sulfonyl amide unit sulfone skeleton were conveniently synthesized.
Язык: Английский
Процитировано
3
Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown
Опубликована: Окт. 25, 2024
Abstract Despite recent advances in cluster‐based catalysis for organic synthesis, the substrate scope of reactions catalyzed by metal nanoclusters is typically not superior to previously established catalytic systems. Herein, we develop new atomically precise copper protosilylation, with expanding alkenes and simple enynes that were suitable prior synthetic methodologies traditional complexes. The involvement a second center kernel during migratory insertion step thought be responsible expanded scope. In addition, reaction highly compatible water can carried out open air rather than under inert gas protection. Mechanistic studies suggest cluster‐catalyzed protosilylation proceeds absence silyl radicals. current findings demonstrate potential using practical sustainable chemical synthesis.
Язык: Английский
Процитировано
3
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(22), С. 16463 - 16472
Опубликована: Окт. 24, 2024
Geminal and vicinal borosilanes have unique applications in functional materials synthetic transformations. Herein, a convenient method for the synthesis of geminal is developed via photoredox metal-free hydrosilylation vinylboronic esters. This strategy features advantages high atom economy, environmental friendliness, excellent group compatibility. The mechanism studies reveal that catalytic reaction goes through HAT catalysis radical addition pathway.
Язык: Английский
Процитировано
1
European Journal of Organic Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Abstract Alkenes and alkynes are inexpensive readily available basic chemicals. Silyl radical‐participated silylation of alkenes provides a powerful tool for the direct construction organosilicon compounds. Compared to hydrosilylation reactions, silylfunctionalization reactions more attractive advantageous in building diverse compounds, which has led their becoming research focus organic synthesis. Herein, we provide comprehensive overview recent advances silyl alkynes.
Язык: Английский
Процитировано
1
Angewandte Chemie, Год журнала: 2024, Номер unknown
Опубликована: Окт. 25, 2024
Abstract Despite recent advances in cluster‐based catalysis for organic synthesis, the substrate scope of reactions catalyzed by metal nanoclusters is typically not superior to previously established catalytic systems. Herein, we develop new atomically precise copper protosilylation, with expanding alkenes and simple enynes that were suitable prior synthetic methodologies traditional complexes. The involvement a second center kernel during migratory insertion step thought be responsible expanded scope. In addition, reaction highly compatible water can carried out open air rather than under inert gas protection. Mechanistic studies suggest cluster‐catalyzed protosilylation proceeds absence silyl radicals. current findings demonstrate potential using practical sustainable chemical synthesis.
Язык: Английский
Процитировано
0
Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 23, 2024
A novel, mild, and environmentally friendly method was developed for the synthesis of quaternary-carbon-containing succinyldiamides. This found to be compatible with many substrates.
Язык: Английский
Процитировано
0