Copper‐Catalyzed Cascade Phosphorodithiolation/Cyclization of β‐Ketodinitriles: Organic Transformation of P4S10
Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 27, 2025
Comprehensive
Summary
An
innovative
approach
to
synthesizing
pyrrole‐functionalized
phosphorodithioates
via
a
copper‐catalyzed
cascade
phosphorodithiolation/cyclization
of
β‐ketodinitriles
is
disclosed.
This
method
employs
tetraphosphorus
decasulfide
(P
4
S
10
)
as
phosphorus
source,
activated
by
alcohols
under
mild
conditions.
A
wide
range
and
are
well‐tolerated,
affording
the
desired
products
with
good
excellent
yields,
underscoring
broad
functional
group
compatibility.
Notably,
this
process
eschews
need
for
noble
metal
catalysts,
aligning
green
chemistry
principles
enabling
direct
sustainable
transformation
from
inorganic
organic
phosphorus.
Furthermore,
synthesized
demonstrate
potent
antibacterial
properties
against
Staphylococcus
aureus
.
Язык: Английский
Pd-catalyzed 5-exo-dig cyclization/etherification cascade of N-propargyl arylamines for the synthesis of polysubstituted furans
Chemical Communications,
Год журнала:
2024,
Номер
60(60), С. 7721 - 7724
Опубликована: Янв. 1, 2024
A
method
for
the
synthesis
of
furans
bearing
indoline
skeletons
was
developed
Язык: Английский
Iron-Catalyzed Cross-Dehydrogenative Coupling of para-Quinone Methides with Formamides: In Situ Activation of C(sp2)–H Bonds
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(22), С. 16663 - 16678
Опубликована: Ноя. 1, 2024
A
novel
and
straightforward
method
for
the
iron-catalyzed
regioselective
cross-dehydrogenative
coupling
of
para-quinone
methides
(p-QMs)
with
formamides
has
been
developed,
facilitated
by
in
situ
activation
C(sp2)–H
bonds
formyl
alkenyl
substituents
via
a
radical
strategy.
This
does
not
require
preactivation
substrates,
it
can
accommodate
wide
range
p-QMs
under
optimized
reaction
conditions,
resulting
formation
expected
C-7
acetamides-functionalized
moderate
to
good
yields.
The
control
experiments
revealed
that
follows
fundamental
equation
second-order
kinetics.
Additionally,
an
exploration
Hammett
effect
was
undertaken
elucidate
impact
reaction.
In
combination
DFT
calculation,
plausible
mechanism
proposed
through
meticulously
controlled
experiments.
Язык: Английский
Copper‐Catalyzed Regioselective Cyanation/Diarylmethylation of Formamides: Construction of α‐Cyano Functionalized Tetra‐Substituted Olefins
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 14, 2024
Comprehensive
Summary
A
copper‐catalyzed
cyanation/diarylmethylation
of
formamides
has
been
developed
for
the
synthesis
α‐cyano
functionalized
tetra‐substituted
olefins
by
utilizing
para
‐quinone
methides
(
p
‐QMs)
and
trimethylcyanosilane
as
functionalization
sources.
Various
kinds
‐QMs
are
well
tolerated,
delivering
desired
products
with
72%—94%
yields,
demonstrating
broad
functional
group
tolerance.
Notably,
reaction
does
not
require
noble
metals
proceeds
regioselectively
under
mild
conditions.
Based
on
step‐by‐step
control
experiments,
Hammett
studies
DFT
calculation,
a
plausible
mechanism
is
proposed.
Язык: Английский