β-Thioamide Sulfone Enabled Copper-Catalyzed Ring-Opening/Sulfonylation of Cyclopropenes: Access to Alkyl Aryl Sulfones
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
Sulfone
motifs
play
important
roles
in
bioactive
compounds
and
functional
materials.
The
development
of
efficient
methodologies
for
constructing
sulfonyl-containing
has
thus
attracted
considerable
attention.
Here,
we
introduce
a
protocol
the
preparation
alkyl
aryl
sulfones
under
mild
conditions.
This
employs
β-thioamide
sulfone
as
novel
motif
donor.
It
forms
sulfinates
situ
basic
conditions,
which
then
undergo
cross-coupling
with
intermediates
that
were
generated
from
ligand-free
copper-catalyzed
cyclopropenes
(CPEs)
ring
opening.
Язык: Английский
Catalyst-Free Radical Dearomatization of Phenols with Aryldiazonium Tetrafluoroborates and DABCO·(SO2)2
Synlett,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
Abstract
A
catalyst-free,
three-component
dearomatization
of
phenols
with
aryldiazonium
tetrafluoroborates
and
DABCO·(SO2)2
has
been
developed
for
the
synthesis
4-(arylsulfonyl)cyclohex-2,5-dien-1-one
scaffolds.
This
method
offers
mild
reaction
conditions
high
step
efficiency,
providing
a
green
efficient
strategy
phenols.
Mechanistic
studies
indicated
that
this
transformation
relies
on
tandem
radical
sulfur
dioxide
insertion
process.
Язык: Английский