Copper(I)-Photocatalyzed Addition of Trichloromethanesulfenyl Chloride to Olefinic Compounds

Molecules, Год журнала: 2025, Номер 30(3), С. 661 - 661

Опубликована: Фев. 2, 2025

Atom transfer radical addition (ATRA) reactions are essential transformations in organic synthetic chemistry that enable the atom-economic difunctionalization of abundant olefin feedstocks. In this way, a rich chemical space can be opened up by well-planned combinations simple starting materials. To build an efficient photocatalytic transformation, reactivity trichloromethanesulfenyl chloride toward alkenes and alkynes was investigated under Cu(I) reaction conditions. study, we found added to series olefins (such as styrenes electron-rich -poor olefins) presence 1 mol% [Cu(dmp)2]BF4 photocatalyst blue LED irradiation, producing α-chloro trichloromethylthioethers good yields. Experimental theoretical (DFT) mechanistic studies consistent with proposed chain mechanism transformation. This study may serve valuable reference for development new coupling economical highly processes.

Язык: Английский

Copper-Catalyzed Regioselective 1,4-Sulfonyl Indolylation of 1,3-Dienes with Sulfonyl Chloride and Indoles

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 22, 2025

A copper-based catalytic system has been described to enable the efficient 1,4-sulfonylindolylation of 1,3-dienes with sulfonyl chloride and indoles. This protocol offers a practical method for synthesis allylsulfone-containing indole derivatives broad range compatible functionalities excellent chemo- regioselectivities. Mechanistic studies suggest that copper catalyst plays dual role initiating radicals prompting coupling in this conjugated diene-selective 1,4-difunctionalization strategy.

Язык: Английский

Emerging Trends in Microwave and Ultrasound/Visible Light/ Carbene Intermediates & Carbonylation/Metal-Catalyzed Mediated Synthesis of β-Lactams (2021-2024)

Tetrahedron, Год журнала: 2024, Номер unknown, С. 134429 - 134429

Опубликована: Дек. 1, 2024

Язык: Английский