Photo- and Electro-chemical Strategies for Indazole Synthesis DOI Creative Commons
Binbin Huang

Tetrahedron Chem, Год журнала: 2024, Номер unknown, С. 100116 - 100116

Опубликована: Дек. 1, 2024

The indazole core is prevalently found in the structures of bioactive molecules, demonstrating promising potential medicinal chemistry and drug discovery, which therefore has attracted sustained attention from synthetic community. Over recent decades, significant progress been achieved both organic photocatalysis electrosynthesis, offering novel approaches for efficient sustainable synthesis various functionalized indazoles. This mini-review highlights emerging methodological advancements photo-/electro-chemical two common forms indazole, namely 1H- 2H-indazoles, are classified by specific intramolecular bond formation patterns: (1) C-C formation, (2) C-N (3) N-N formation. reaction conditions, representative scopes, mechanistic understandings these protocols emphasized, to elucidate advantages limitations current strategies, with an aim inspire future innovations that may address challenges modern synthesis.Graphical abstractTo create your abstract, type over instructions template box below. Fonts or abstract dimensions should not be changed altered.

Язык: Английский

Room Temperature Access to Bridged Nitrogen Ligands via Electroreductive Annulation of 1,10-Phenanthrolines and Imines DOI
Chengqian Zhang,

Maorui Wang,

Min Zhang

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

An electroreductive annulation reaction of 1,10-phenanthrolines and imines has been developed. This method proceeds with broad substrate functionality tolerance, high selectivity, no need for pressurized H2 gas or transition metal catalysts. Mechanistic studies reveal that the products are formed via simultaneous electroreduction both proton-activated reactants followed by radical cross-coupling intramolecular cyclization coupling adduct.

Язык: Английский

Процитировано

0
Photo- and Electro-chemical Strategies for Indazole Synthesis DOI Creative Commons
Binbin Huang

Tetrahedron Chem, Год журнала: 2024, Номер unknown, С. 100116 - 100116

Опубликована: Дек. 1, 2024

The indazole core is prevalently found in the structures of bioactive molecules, demonstrating promising potential medicinal chemistry and drug discovery, which therefore has attracted sustained attention from synthetic community. Over recent decades, significant progress been achieved both organic photocatalysis electrosynthesis, offering novel approaches for efficient sustainable synthesis various functionalized indazoles. This mini-review highlights emerging methodological advancements photo-/electro-chemical two common forms indazole, namely 1H- 2H-indazoles, are classified by specific intramolecular bond formation patterns: (1) C-C formation, (2) C-N (3) N-N formation. reaction conditions, representative scopes, mechanistic understandings these protocols emphasized, to elucidate advantages limitations current strategies, with an aim inspire future innovations that may address challenges modern synthesis.Graphical abstractTo create your abstract, type over instructions template box below. Fonts or abstract dimensions should not be changed altered.

Язык: Английский

Процитировано

1