Journal of Biophotonics,
Год журнала:
2024,
Номер
17(4)
Опубликована: Янв. 14, 2024
Abstract
We
studied
grafted
tumors
obtained
by
subcutaneous
implantation
of
kidney
cancer
cells
into
male
white
rats.
Gold
nanorods
with
a
plasmon
resonance
about
800
nm
were
injected
intratumorally
for
photothermal
heating.
Experimental
irradiation
was
carried
out
percutaneously
using
near‐infrared
diode
laser.
Changes
in
the
optical
properties
tissues
spectral
range
350–2200
under
plasmonic
therapy
(PPT)
studied.
Analysis
observed
changes
absorption
bands
water
and
hemoglobin
made
it
possible
to
estimate
depth
thermal
damage
tumor.
A
significant
decrease
peaks
spectrum
upper
peripheral
part
especially
tumor
capsule.
The
laser
can
be
used
optimize
laboratory
clinical
PPT
procedures.
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Июль 8, 2023
Laser-induced
thermotherapy
has
shown
promising
potential
for
the
treatment
of
unresectable
primary
pancreatic
ductal
adenocarcinoma
tumors.
Nevertheless,
heterogeneous
tumor
environment
and
complex
thermal
interaction
phenomena
that
are
established
under
hyperthermic
conditions
can
lead
to
under/over
estimation
laser
efficacy.
Using
numerical
modeling,
this
paper
presents
an
optimized
setting
Nd:YAG
delivered
by
a
bare
optical
fiber
(300
µm
in
diameter)
at
1064
nm
working
continuous
mode
within
power
range
2-10
W.
For
analysis,
patient-specific
3D
models
were
used,
consisting
tumors
different
portions
pancreas.
The
time
ablating
completely
producing
toxic
effects
on
possible
residual
cells
beyond
margins
found
be
5
W
550
s,
7
8
s
tail,
body,
head
tumors,
respectively.
Based
results,
during
irradiation
doses,
injury
was
not
evident
either
15
mm
lateral
distances
from
or
nearby
healthy
organs.
present
computational-based
predictions
also
line
with
previous
ex
vivo
studies,
hence,
they
assist
therapeutic
outcome
ablation
neoplasms
prior
clinical
trials.
Nanotechnology,
Год журнала:
2024,
Номер
35(46), С. 465101 - 465101
Опубликована: Авг. 15, 2024
We
present
an
intelligent
photothermal
therapy
agents
by
functionalizing
gold
nanoparticles
with
specific
nucleic
acid
sequences.
Hairpin
acids
are
modified
to
the
nanoparticles,
forming
AuNPs-1
and
AuNPs-2.
Upon
infiltrating
cancer
cells,
these
undergo
catalytic
hairpin
assembly
in
presence
of
target
miRNA,
leading
aggregation
subsequent
conversion.
Under
near-infrared
laser
irradiation,
aggregated
exhibit
efficient
conversion,
selectively
damaging
cells.
This
approach
offers
heightened
selectivity,
as
only
aggregate
environments
biomarkers
present,
sparing
normal
Cytotoxicity
assays
confirm
minimal
toxicity
In
vivo
studies
on
mice
bearing
solid
tumors
validate
system's
efficacy
tumor
regression.
Overall,
this
study
highlights
potential
acid-functionalized
selective
therapy,
offering
insights
for
targeted
diagnosis
treatment
development.
Cancers,
Год журнала:
2024,
Номер
16(21), С. 3656 - 3656
Опубликована: Окт. 30, 2024
The
abscopal
effect
is
a
systemic
immune
response
characterized
by
metastases
regression
at
sites
distant
from
the
irradiated
lesion.
This
systematic
review
aims
to
explore
immunological
mechanisms
of
action
underlying
and
investigate
how
hyperthermia
(HT)
can
increase
chances
radiotherapy
(RT)
triggering
anti-tumor
responses.
Journal of Biophotonics,
Год журнала:
2024,
Номер
17(4)
Опубликована: Янв. 14, 2024
Abstract
We
studied
grafted
tumors
obtained
by
subcutaneous
implantation
of
kidney
cancer
cells
into
male
white
rats.
Gold
nanorods
with
a
plasmon
resonance
about
800
nm
were
injected
intratumorally
for
photothermal
heating.
Experimental
irradiation
was
carried
out
percutaneously
using
near‐infrared
diode
laser.
Changes
in
the
optical
properties
tissues
spectral
range
350–2200
under
plasmonic
therapy
(PPT)
studied.
Analysis
observed
changes
absorption
bands
water
and
hemoglobin
made
it
possible
to
estimate
depth
thermal
damage
tumor.
A
significant
decrease
peaks
spectrum
upper
peripheral
part
especially
tumor
capsule.
The
laser
can
be
used
optimize
laboratory
clinical
PPT
procedures.
