Application of Nanomaterials in the Diagnosis and Treatment of Retinal Diseases
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
Abstract
In
recent
years,
nanomaterials
have
demonstrated
broad
prospects
in
the
diagnosis
and
treatment
of
retinal
diseases
due
to
their
unique
physicochemical
properties,
such
as
small‐size
effects,
high
biocompatibility,
functional
surfaces.
Retinal
are
often
accompanied
by
complex
pathological
microenvironments,
where
conventional
diagnostic
therapeutic
approaches
face
challenges
low
drug
delivery
efficiency,
risks
associated
with
invasive
procedures,
difficulties
real‐time
monitoring.
Nanomaterials
hold
promise
addressing
these
limitations
traditional
therapies,
thereby
improving
precision
efficacy.
The
applications
diagnostics
summarized,
they
enable
high‐resolution
imaging
carrying
fluorescent
probes
or
contrast
agents
act
biosensors
sensitively
detect
disease‐related
biomarkers,
facilitating
early
dynamic
therapeutics,
functionalized
nanocarriers
can
precisely
deliver
drugs,
genes,
antioxidant
molecules
target
cells,
significantly
enhancing
outcomes
while
reducing
systemic
toxicity.
Additionally,
nanofiber
materials
possess
properties
that
make
them
particularly
suitable
for
regeneration
tissue
engineering.
By
loading
neurotrophic
factors
into
scaffolds,
regenerative
effects
be
amplified,
promoting
repair
neurons.
Despite
immense
potential,
clinical
translation
still
requires
long‐term
biosafety,
scalable
manufacturing
processes,
optimization
targeting
efficiency.
Язык: Английский
Vitamin A Precursor: Beta-Carotene Alleviates the Streptozotocin-Induced Diabetic Retinopathy in Male Adult Zebrafish via the Regulation of the Polyol Pathway
Jordan Journal of Pharmaceutical Sciences,
Год журнала:
2025,
Номер
18(1), С. 272 - 291
Опубликована: Март 25, 2025
Diabetic
retinopathy
(DR)
is
a
progressive
neurovascular
disorder
due
to
damage
retinal
blood
vessels.
Beta-carotene
acts
as
chromophores
and
initiates
photo-transduction
epithelial
maintenance.
(BC)
present
in
palm
oil
mill
effluent,
it
called
effluent-derived
beta-carotene
(PBC).
The
study
designed
evaluate
the
effect
of
PBC
streptozotocin-induced
DR
zebrafish
by
measuring
oxidative
stress,
inflammation,
polyol
pathway
markers.
five
groups
healthy
Danio
rerio
were
used
this
study.
diabetes
was
instigated
intraperitoneal
administration
streptozotocin
(STZ)
followed
intravitreal
STZ
on
7th
day.
exposure
(50
100
mg/L)
dexamethasone
(DEX)
administered
for
21
continuous
days.
DR-associated
visual
behaviours
i.e.,
optomotor
response
(OMR)
startle
(SR)
appraised
0,
7,
14,
21st
biochemical
changes
plasma
glucose
&
homocysteine
(HCY);
tissue
lipid
peroxidation,
reduced
glutathione
(GSH),
tumor
necrosis
factor-alpha
(TNF-α),
superoxide
dismutase
(SOD)
total
protein
levels
estimated.
lens
evaluation
markers
sorbitol
dehydrogenase
(SDH)
aldose
reductase
(AR)
activity.
potentially
attenuated
with
regulation
abnormalities
which
similar
DEX
treated
group.
Hence,
can
be
management
its
anti-hyperglycemia,
antioxidant,
anti-inflammatory,
regulatory
actions.
Язык: Английский