Advancement in 3D Printable Materials for the Management of Cancer: A New Era of Materialistic Approach for the Treatment of Cancer

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 100, С. 106064 - 106064

Опубликована: Авг. 14, 2024

Язык: Английский

Hybrid-integrated devices for mimicking malignant brain tumors (“tumor-on-a-chip”) for in vitro development of targeted drug delivery and personalized therapy approaches

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Ноя. 19, 2024

Acute and requiring attention problem of oncotheranostics is a necessity for the urgent development operative precise diagnostics methods, followed by efficient therapy, to significantly reduce disability mortality citizens. A perspective way achieve personalized treatment use methods evaluation individual drug load, properties specific tumors effectiveness selected other actual features pathology. Among vast diversity tumor types-brain are most invasive malignant in humans with poor survival after diagnosis. brain glioblastoma shows exceptionally high mortality. More studies urgently needed understand risk factors improve therapy approaches. One actively developing approaches tumor-on-a-chip (ToC) concept. This review examines achievements recent years field ToC system developments. The basics microfluidic chips technologies considered context their applications solving oncological problems. Then basic principles cultivation evaluate main challengers implementation devices, growing cell cultures possibilities observation. culture types advantages being analyzed. modeling angiogenesis blood-brain barrier (BBB) on chip, principally important elements life system, were detail. interesting examples developments have been presented.

Язык: Английский

Unraveling new avenues in pancreatic cancer treatment: A comprehensive exploration of drug repurposing using transcriptomic data

Computers in Biology and Medicine, Год журнала: 2024, Номер 185, С. 109481 - 109481

Опубликована: Дек. 6, 2024

Язык: Английский