From Bench to Bedside: The Role of Extracellular Vesicles in Cartilage Injury Treatment DOI Creative Commons
Pan Jin, Huan Liu,

Xichi Chen

и другие.

Biomaterials Research, Год журнала: 2024, Номер 28

Опубликована: Янв. 1, 2024

Cartilage repair is the key to treatment of joint-related injury. However, because cartilage lacks vessels and nerves, its self-repair ability extremely low. Extracellular vesicles (EVs) are bilayer nanovesicles with membranes mainly composed ceramides, cholesterol, phosphoglycerides, long-chain free fatty acids, containing DNA, RNA, proteins (such as integrins enzymes). For mediating intercellular communication regulating mechanisms, EVs have been shown by multiple studies be effective options for repair. This review summarizes recent findings different sources (mammals, plants, bacteria) uses in repair, mechanisms captured injured chondrocytes, quantification storage EVs, which may provide scientific guidance promoting development field injury treatment.

Язык: Английский

Engineered Extracellular Vesicles Derived from Juvenile Mice Enhance Mitochondrial Function in the Aging Bone Microenvironment and Achieve Rejuvenation DOI

Jiaqian Zheng,

Yipeng Ren,

Junhua Ke

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

Aging-related bone degeneration and impaired healing capacity remain significant challenges in regenerative medicine, necessitating innovative, efficient, targeted strategies to restore health. Here, we engineered extracellular vesicles (EVs) derived from the serum of pretreated juvenile mice, with goals reversing aging, enhancing osteogenic potential, increasing bioavailability rejuvenate aging environment. First, established models representing different phases identify EV type highest potential for improving microenvironment older individuals. Second, employed DSS6 targeting enhance biological effects selected EVs vivo. The effectively repair sites promoted fracture more than unmodified mice. RNA sequencing revealed that translocase outer mitochondrial membrane 7 (Tomm7) is crucial underlying mechanism. Silencing Tomm7 significantly diminished positive regulatory EVs. Specifically, may function cells by activating Tomm7-mediated Pink1/Parkin mitophagy pathway, promoting stemness recovery marrow stromal (BMSCs) adverse conditions microenvironment. Overall, developed mice offer an alternative approach treating bones. identified mechanisms provide a valuable reference precision treatment bones future.

Язык: Английский

Процитировано

0

From Bench to Bedside: The Role of Extracellular Vesicles in Cartilage Injury Treatment DOI Creative Commons
Pan Jin, Huan Liu,

Xichi Chen

и другие.

Biomaterials Research, Год журнала: 2024, Номер 28

Опубликована: Янв. 1, 2024

Cartilage repair is the key to treatment of joint-related injury. However, because cartilage lacks vessels and nerves, its self-repair ability extremely low. Extracellular vesicles (EVs) are bilayer nanovesicles with membranes mainly composed ceramides, cholesterol, phosphoglycerides, long-chain free fatty acids, containing DNA, RNA, proteins (such as integrins enzymes). For mediating intercellular communication regulating mechanisms, EVs have been shown by multiple studies be effective options for repair. This review summarizes recent findings different sources (mammals, plants, bacteria) uses in repair, mechanisms captured injured chondrocytes, quantification storage EVs, which may provide scientific guidance promoting development field injury treatment.

Язык: Английский

Процитировано

2