High‐Efficiency Gold Nanoaggregates for NIR LED‐Driven Sustained Mild Photothermal Therapy Achieving Complete Tumor Eradication and Immune Enhancement
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 15, 2024
Abstract
For
millennia,
humans
have
harnessed
thermal
energy
to
treat
cancer.
However,
delivering
tumor
tissues
in
traditional
hyperthermia
remains
a
significant
challenge.
Nanotechnology
has
revolutionized
this
approach,
enabling
nanomaterials
target
tumors
precisely
and
act
as
internal
heat
sources.
Nanomaterial‐based
photothermal
therapy
employs
nano‐photothermal
agents
absorb
near‐infrared
light
convert
it
into
heat,
offering
non‐invasive,
highly
controllable,
specific
treatment
for
solid
tumors.
Nonetheless,
achieving
complete
eradication,
preventing
recurrence,
ensuring
safety
continue
be
major
concerns.
To
address
these
issues,
sustained
mild
(smPTT)
is
proposed,
utilizing
gold
nanoaggregates
(AuNAs)
with
high
conversion
efficiency
(92.8%)
combination
single
irradiation
of
low‐power
(∼0.1
W
cm
−
2
)
LED
light.
This
method
achieved
eradication
animal
models,
no
recurrence
over
long‐term
(>180
days)
monitoring.
strategy
provides
superior
therapeutic
effects
compared
higher
than
high‐temperature
therapy.
Additionally,
induces
strong
immune
response
memory,
crucial
metastasis.
novel
approach
may
significantly
impact
clinical
applications
shallow
offer
new
avenues
immunotherapy.
Язык: Английский
Inorganic Nanomaterials Meet the Immune System: An Intricate Balance
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Abstract
The
immune
system
provides
defense
against
foreign
agents
that
are
considered
harmful
for
the
organism.
Inorganic
nanomaterials
can
be
recognized
by
as
antigens,
inducing
an
reaction
dependent
on
patient's
immunological
anamnesis
and
from
several
factors
including
size,
shape,
chemical
nature
of
nanoparticles.
Furthermore,
nanomaterials‐driven
immunomodulation
might
exploited
therapeutic
purposes,
opening
new
horizons
in
oncology
beyond.
In
this
scenario,
we
present
a
critical
review
state
art
regarding
preclinical
evaluation
effects
most
promising
metals
biomedical
applications
(gold,
silver,
copper)
system.
Because
exploiting
interactions
between
inorganic
may
result
game
changer
management
(non)communicable
diseases,
within
encounter
need
to
summarize
organize
plethora
sometimes
inconsistent
information,
analyzing
challenges
providing
expected
perspectives.
field
is
still
its
infancy,
our
work
emphasizes
deep
understanding
influence
features
metal
both
cultured
cells
animal
models
pivotal
safe
translation
nanotherapeutics
clinical
practice.
Язык: Английский
Neoadjuvant Hyperthermia Combined with Hybrid Nanoarchitectures Enhances Chemoradiotherapy Efficacy in Head and Neck Carcinoma
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(33), С. 43272 - 43282
Опубликована: Авг. 10, 2024
Head
and
neck
squamous
cell
carcinomas
are
characterized
by
a
high
incidence
of
recurrence,
especially
in
patients
with
locally
advanced
disease.
Standard
treatment
strategies
can
be
associated
severe
side
effects
to
healthy
tissues
that
negatively
impact
the
patient's
quality
life.
Hyperthermia
(HT)
is
noninvasive
modality
has
improved
effectiveness
chemotherapy
(CT)
and/or
radiotherapy
(RT)
for
management
some
solid
neoplasms.
In
this
context,
association
approach
rationally
designed
nanomaterials
may
further
enhance
outcome.
study,
we
demonstrate
enhanced
effect
neoadjuvant
HT
combination
hybrid
nanoarchitectures
enclosing
cisplatin
prodrug
(NAs-CisPt)
RT.
All
treatments
their
combinations
have
been
fully
evaluated
employing
standardized
chorioallantoic
membrane
tumor
models
HPV-negative
head
carcinoma.
An
tumor-shrinking
was
observed
administration
trimodal
(HT/NAs-CisPt/RT),
which
also
highlighted
significant
increase
apoptosis.
Our
findings
nanotechnology-based
CT
RT
certain
order
enhances
vivo
On
broader
basis,
study
paves
way
next
exploration
approaches
clinical
oral
cancer
based
on
innovative
strategies.
Язык: Английский
Invasiveness modulation of glioma cells by copper complex-loaded nanoarchitectures
Colloids and Surfaces B Biointerfaces,
Год журнала:
2024,
Номер
245, С. 114187 - 114187
Опубликована: Авг. 31, 2024
Among
the
tumors
with
highest
lethality,
gliomas
are
primary
brain
associated
common
recurrence
inclined
to
metastasize
along
neuraxis
and
occasionally
out
of
central
nervous
system.
Even
though
metastasis
is
main
responsible
for
death
in
oncological
patients,
few
dedicated
treatments
approved.
Therefore,
establishment
effective
anti-metastasis
agents
final
frontier
cancer
research.
Interestingly,
some
copper
complexes
have
demonstrated
promising
efficacy
as
antimetastatic
agents,
but
they
may
cause
off-site
effects
such
alteration
homeostasis
healthy
tissues.
Thus,
incorporation
copper-based
rationally
designed
nano-architectures
can
increase
treatment
localization
reducing
side
effects.
Here,
complex
loaded
hybrid
(CuLNAs)
presented
employed
assess
impact
an
intracellular
source
on
glioma
cell
invasiveness.
The
novel
CuLNAs
fully
characterized
exploited
migration
modulation
a
line.
results
demonstrate
that
significantly
reduce
without
impairing
proliferation
compared
standard
gold
NAs.
A
concomitant
antimigratory-like
regulation
epithelial-to-mesenchymal
transition
genes
confirmed
these
results,
gene
encoding
epithelial
protein
E-cadherin
was
upregulated
other
explored
mesenchymal
were
downregulated.
These
findings,
together
intrinsic
behaviors
NAs,
inclusion
metal
approach
composition
family
activity.
Язык: Английский