Advanced Functional Materials,
Год журнала:
2024,
Номер
34(24)
Опубликована: Фев. 19, 2024
Abstract
Bone
implant
biomaterials
are
among
the
most
used
materials
for
clinical
application.
Despite
significant
advances
in
biocompatibility
and
osteoconductivity,
conventional
lack
ability
to
cope
with
pathological
microenvironment
(inflammation,
infection,
residual
tumors,
etc.)
during
bone
repair.
Semiconductor
have
unique
electrical,
optical,
ultrasound,
thermal
response
properties,
which
facilitate
non‐invasively
controllably
dynamic
repair
of
defects.
In
this
review,
design
synthesis
a
new
generation
semiconductor‐driven
summarized,
mechanism
action
semiconductive
biomaterials'
functional
interfaces
process
tissues
discussed,
strategies
problems
encountered
osseointegration
is
provided.
Finally,
review
outlooks
future
implants
defect
Abstract
For
a
long
time,
optical
imaging
of
the
deep
brain
with
high
resolution
has
been
challenge.
Recently,
advance
in
second
near‐infrared
(NIR‐II)
bioimaging
techniques
and
contrast
agents,
NIR‐II
window
attracted
great
attention
to
monitoring
deeper
biological
or
pathophysiological
processes
signal‐to‐noise
ratio
(SNR)
spatiotemporal
resolution.
Assisted
bioimaging,
modulation
structure
function
is
promising
be
noninvasive
more
precise.
Herein,
this
review,
first
advantage
light
from
interaction
between
tissue
elaborated.
Then,
several
specific
technologies
are
introduced,
including
fluorescence
imaging,
multiphoton
photoacoustic
imaging.
Furthermore,
corresponding
agents
summarized.
Next,
application
various
visualizing
characteristics
cerebrovascular
network
changes
pathology
signals
will
presented.
After
that,
based
on
discussed,
treatment
glioblastoma,
guidance
cell
transplantation,
neuromodulation.
In
end,
future
perspectives
that
would
help
improve
clinical
translation
proposed.
Advanced Materials,
Год журнала:
2023,
Номер
35(42)
Опубликована: Сен. 19, 2023
Abstract
Optogenetic
modulation
of
brain
neural
activity
that
combines
optical
and
electrical
modes
in
a
unitary
system
has
recently
gained
robust
momentum.
Controlling
illumination
spatial
coverage,
designing
light‐activated
modulators,
developing
wireless
light
delivery
data
transmission
are
crucial
for
maximizing
the
use
neuromodulation.
To
this
end,
biocompatible
electrodes
with
enhanced
optoelectrical
performance,
device
integration
multiplexed
addressing,
transmission,
multimodal
operation
soft
systems
have
been
developed.
This
review
provides
an
outlook
uniformly
illuminating
large
areas
while
spatiotemporally
imaging
responses
upon
stimulation
little
artifacts.
Representative
concepts
important
breakthroughs,
such
as
head‐mounted
illumination,
multiple
implanted
fibers,
micro‐light‐delivery
devices,
discussed.
Examples
techniques
incorporate
electrophysiological
monitoring
presented.
Challenges
perspectives
posed
further
research
efforts
toward
high‐density
interface
modulation,
potential
nonpharmacological
neurological
disease
treatments
stimulation.
Abstract
Fluorescent
dyes
that
emit
in
the
second
near‐infrared
(NIR‐II,
1000–3000
nm)
region
have
provided
significant
advances
toward
real‐time
and
high‐resolution
imaging
of
vessel
lymphatic
system.
However,
vivo
NIR‐II
tracking
fate
labeled
cells
still
remains
challenging.
Here,
we
develop
a
shielding
unit–donor–acceptor–donor–shielding
unit
(S‐D‐A‐D‐S)
fluorophore
(FE‐4ZW)
with
zwitterionic
terminal
groups
for
high‐efficiency
cell
labeling
without
using
cell‐penetrating
peptides,
which
provides
enhanced
non‐invasive
determination
location
migration.
The
tethering
sulfoammonium
inner
salts
are
featured
its
high
affinity
membranes,
thereby
enabling
stable
even
fixed
cells.
transplanted
stem
tumor
migration
along
system
brain
or
periphery
tissues
clearly
monitored
by
cell‐internalized
FE‐4ZW.
We
also
confirmed
clinically
used
surfactant,
D‐α‐tocopheryl
polyethylene
glycol‐1000
succinate,
can
reduce
liver
spleen
uptake
design
strategy
cell‐labeling
technology
reported
here
open
new
realm
visualization
insight
into
relocation
process,
ultimately
providing
an
opportunity
to
investigate
greater
detail
underlying
mechanisms
therapy
metastasis.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(24)
Опубликована: Фев. 19, 2024
Abstract
Bone
implant
biomaterials
are
among
the
most
used
materials
for
clinical
application.
Despite
significant
advances
in
biocompatibility
and
osteoconductivity,
conventional
lack
ability
to
cope
with
pathological
microenvironment
(inflammation,
infection,
residual
tumors,
etc.)
during
bone
repair.
Semiconductor
have
unique
electrical,
optical,
ultrasound,
thermal
response
properties,
which
facilitate
non‐invasively
controllably
dynamic
repair
of
defects.
In
this
review,
design
synthesis
a
new
generation
semiconductor‐driven
summarized,
mechanism
action
semiconductive
biomaterials'
functional
interfaces
process
tissues
discussed,
strategies
problems
encountered
osseointegration
is
provided.
Finally,
review
outlooks
future
implants
defect
