One-Pot Rapid Synthesis of Cu2+-Doped GOD@MOF to Amplify the Antitumor Efficacy of Chemodynamic Therapy DOI
Qing Li, Jiantao Yu, Lin Li

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(13), С. 16482 - 16491

Опубликована: Март 27, 2023

Chemodynamic therapy (CDT) relies on the transformation of intracellular hydrogen peroxide (H2O2) to hydroxyl radicals (·OH) with higher toxicity under catalysis Fenton/Fenton-like reagents, which amplifies oxidative stress and induces significant cellular apoptosis. However, CDT efficacy is generally limited by overexpressed GSH insufficient endogenous H2O2 in tumors. Co-delivery Cu2+ glucose oxidase (GOD) can lead a Cu2+/Cu+ circulation realize depletion amplify Fenton-like reaction. pH-responsive metal-organic frameworks (MOFs) are optical choice deliver ions considering that aqueous condition requisite for GOD encapsulation, it challenging abundantly dope ZIF-8 MOF nanoparticles conditions due ease precipitation enlarged crystal size. In this work, robust one-pot biomimetic mineralization method using excessive ligand precursors developed synthesize GOD@Cu-ZIF-8. Copper doped GOD@Cu-ZIF-8 eliminate produce Cu+, further proceeded reaction presence GOD-catalyzed H2O2. Through breaking tumor microenvironment homeostasis producing an enhanced effect, promising antitumor capability was evidenced experiments both vitro vivo.

Язык: Английский

Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies DOI Creative Commons
Md Entaz Bahar, Hyun Joon Kim, Deok Ryong Kim

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Дек. 18, 2023

Metastatic dissemination of solid tumors, a leading cause cancer-related mortality, underscores the urgent need for enhanced insights into molecular and cellular mechanisms underlying metastasis, chemoresistance, mechanistic backgrounds individuals whose cancers are prone to migration. The most prevalent signaling cascade governed by multi-kinase inhibitors is mitogen-activated protein kinase (MAPK) pathway, encompassing RAS-RAF-MAPK (MEK)-extracellular signal-related (ERK) pathway. RAF primary mediator MAPK responsible sequential activation downstream targets, such as MEK transcription factor ERK, which control numerous physiological processes, including organism development, cell cycle control, proliferation differentiation, survival, death. Defects in this associated with diseases cancer. (RAFi) combined blockers represent an FDA-approved therapeutic strategy RAF-mutant cancers, melanoma, non-small lung carcinoma, thyroid However, development therapy resistance cancer cells remains important barrier. Autophagy, intracellular lysosome-dependent catabolic recycling process, plays critical role RAFi Thus, targeting autophagy could be novel treatment strategies cancers. In review, we delve deeper surrounding tumorigenesis RAFi-resistance. Furthermore, explore discuss ongoing next-generation profiles. Additionally, review sheds light on functional interplay between RAF-targeted therapies

Язык: Английский

Процитировано

292
Confining enzymes in porous organic frameworks: from synthetic strategy and characterization to healthcare applications DOI
Siming Huang, Guosheng Chen, Gangfeng Ouyang

и другие.

Chemical Society Reviews, Год журнала: 2022, Номер 51(15), С. 6824 - 6863

Опубликована: Янв. 1, 2022

This review comprehensively presents the cutting-edge advances of enzyme confinement using different porous organic frameworks.

Язык: Английский

Процитировано

193
Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy DOI Creative Commons
Jie Yang, Dihua Dai, Xi Zhang

и другие.

Theranostics, Год журнала: 2022, Номер 13(1), С. 295 - 323

Опубликована: Дек. 19, 2022

Cancer remains a severe threat to human health. To date, although various therapeutic methods, including radiotherapy (RT), chemotherapy, chemodynamic therapy (CDT), phototherapy, starvation therapy, and immunotherapy, have entered new stage of rapid progress in cancer theranostics, their limited effect significant side effects need be considered carefully. With the development nanotechnology, marriage nanomaterials methods provides practical possibility improve deficiencies therapy. Notably, metal-organic frameworks (MOFs) composed ions/clusters bridging ligands through coordination bonds been widely applied deal with drawbacks different such as effects, low stability, poor efficacy, owing controllable morphologies, tailorable diameters, diverse compositions, tunable porosities, high specific surface areas, facile functionalization, good biocompatibility. This review summarizes recent advanced developments achievements multifunctional MOF-based nanoplatforms for single RT, CDT, phototherapy (photodynamic photothermal therapy), combination methods. Moreover, prospects challenges used tumor are also discussed.

Язык: Английский

Процитировано

147
Advanced Cancer Starvation Therapy by Simultaneous Deprivation of Lactate and Glucose Using a MOF Nanoplatform DOI Creative Commons
Jiantao Yu, Zixiang Wei, Qing Li

и другие.

Advanced Science, Год журнала: 2021, Номер 8(19)

Опубликована: Авг. 7, 2021

Recent investigations reveal that lactate is not a waste product but major energy source for cells, especially in the mitochondria, which can support cellular survival under glucose shortage. Accordingly, new understanding of prompts to target it together with pursue more efficient cancer starvation therapy. Herein, zeolitic imidazolate framework-8 (ZIF-8) nanoplatforms are used co-deliver α-cyano-4-hydroxycinnamate (CHC) and oxidase (GOx) fulfill task simultaneous depriving glucose, resulting nanomedicine CHC/GOx@ZIF-8. The synthesis conditions carefully optimized order yield monodisperse uniform nanomedicines, will ensure reliable steady therapeutic properties. Compared strategies aiming at single carbon source, improved therapy efficacy observed. Besides, than boosting shortage, CHC/GOx@ZIF-8 block lactate-fueled respiration relieve solid tumor hypoxia, enhance GOx catalysis activity, depleting extra producing cytotoxic H2 O2 . By synergistically enhanced anti-tumor effect, both vitro vivo cancer-killing efficacies show twice enhancements mediated results demonstrate dual-depriving advanced strategy strengthening

Язык: Английский

Процитировано

114
Triple-synergistic MOF-nanozyme for efficient antibacterial treatment DOI Creative Commons
M. Wang, Xi Zhou, Yunhong Li

и другие.

Bioactive Materials, Год журнала: 2022, Номер 17, С. 289 - 299

Опубликована: Фев. 1, 2022

The abuse of antibiotics makes bacterial infection an increasingly serious global health threat. Reactive oxygen species (ROS) are the ideal alternative antibacterial approach for quick and effective sterilization. Although various strategies based on ROS have been developed, many them still limited by insufficient efficiency. Here, we developed acid-enhanced dual-modal strategy zeolitic imidazolate frameworks-8 (ZIF8) -derived nanozyme. ZIF8, which can release Zn

Язык: Английский

Процитировано

113
Two-Dimensional MXene-Originated In Situ Nanosonosensitizer Generation for Augmented and Synergistic Sonodynamic Tumor Nanotherapy DOI
Min Zhang, Dayan Yang, Caihong Dong

и другие.

ACS Nano, Год журнала: 2022, Номер 16(6), С. 9938 - 9952

Опубликована: Май 31, 2022

Despite the merits of high tissue-penetrating depth, no ionizing radiation, and low cost, sonodynamic therapy (SDT) still suffers from a quantum yield reactive oxygen species (ROS), limited delivery efficiency, potential toxicity sonosensitizers. Different direct sonosensitizers into tumor tissue for SDT, this work reports fabrication two-dimensional (2D) nanosonosensitizers/nanocatalysts (Ti3C2/CuO2@BSA) in situ generation nanosonosensitizers by responding to microenvironment, achieving high-performance synergistic sonodynamic/chemodynamic therapy. CuO2 nanoparticle integration on 2D Ti3C2 MXene achieved H2O2 an acidic microenvironment oxidizing produce TiO2 nanosonosensitizers, accompanied enhanced separation electrons (e-) holes (h+) carbon matrix after oxidation, further augmenting SDT efficacy. Ultrasound irradiation during process also Cu-initiated Fenton-like reaction more ROS synergizing The experimental results confirm demonstrate therapeutic effects chemodynamic nanotherapy both vitro vivo. antitumor mechanisms therapies are associated with upregulation oxidative phosphorylation, generation, apoptosis as demonstrated RNA sequencing. This thus provides distinct paradigm MXene-originated nanosonosensitizer augmented nanotherapy.

Язык: Английский

Процитировано

98
The Chemistry and Applications of Metal–Organic Frameworks (MOFs) as Industrial Enzyme Immobilization Systems DOI Creative Commons
Allison Silva,

Jeferson Yves Nunes Holanda Alexandre,

José Rodolfo Souza

и другие.

Molecules, Год журнала: 2022, Номер 27(14), С. 4529 - 4529

Опубликована: Июль 15, 2022

Enzymatic biocatalysis is a sustainable technology. Enzymes are versatile and highly efficient biocatalysts, have been widely employed due to their biodegradable nature. However, because the three-dimensional structure of these enzymes predominantly maintained by weaker non-covalent interactions, external conditions, such as temperature pH variations, well presence chemical compounds, can modify or even neutralize biological activity. The enablement this category processes result several advances in areas molecular biology biotechnology achieved over past two decades. In scenario, metal–organic frameworks (MOFs) highlighted supports for enzyme immobilization. They be used ‘house’ specific enzyme, providing it with protection from environmental influences. This review discusses MOFs structures; emphasizes synthesis strategies, properties, applications; explores existing methods using immobilization various enzymes; lists possible modifications combinations other compounds formulate ideal given application.

Язык: Английский

Процитировано

95
Targeting Glucose Metabolism Enzymes in Cancer Treatment: Current and Emerging Strategies DOI Open Access
Yi Zhang, Qiong Li, Zhao Huang

и другие.

Cancers, Год журнала: 2022, Номер 14(19), С. 4568 - 4568

Опубликована: Сен. 21, 2022

Reprogramming of glucose metabolism provides sufficient energy and raw materials for the proliferation, metastasis, immune escape cancer cells, which is enabled by metabolism-related enzymes that are abundantly expressed in a broad range cancers. Therefore, targeting has emerged as promising strategy anticancer drug development. Although several modulators have been approved treatment recent years, some limitations exist, such short half-life, poor solubility, numerous adverse effects. With rapid development medicinal chemicals, more advanced effective enzyme-targeted drugs developed. Additionally, studies found natural products can suppress progression regulating enzymes. In this review, we summarize mechanisms underlying reprogramming present could serve therapeutic targets. addition, systematically review existing enzymes, including small-molecule products. Finally, opportunities challenges also discussed. conclusion, combining with conventional may be strategy.

Язык: Английский

Процитировано

88
Diabetes immunity-modulated multifunctional hydrogel with cascade enzyme catalytic activity for bacterial wound treatment DOI

Mengyuan Deng,

Meng Zhang, Rong Huang

и другие.

Biomaterials, Год журнала: 2022, Номер 289, С. 121790 - 121790

Опубликована: Сен. 5, 2022

Язык: Английский

Процитировано

86
Starvation, Ferroptosis, and Prodrug Therapy Synergistically Enabled by a Cytochrome c Oxidase like Nanozyme DOI

Changyu Cao,

Nan Yang,

Yan Su

и другие.

Advanced Materials, Год журнала: 2022, Номер 34(29)

Опубликована: Май 14, 2022

Nanozymes, which are inorganic nanomaterials mimicking natural enzyme activities, bringing enormous opportunities to theranostics. Herein, a cytochrome c oxidase-like nanozyme (copper-silver alloy nanoparticle, Cu-Ag NP) is demonstrated for nanocatalytic cancer therapy. Loaded with bioreductive predrug (AQ4N), this unprecedentedly enables simultaneous starvation, ferroptosis, and chemical therapy high specificity, able totally eliminate tumor greatly prolong the survival rate 4T1-tumor-bearing mice. The underlying working mechanism revealed both experimentally theoretically.

Язык: Английский

Процитировано

84