Bioinspired oral delivery devices

Nature Reviews Bioengineering, Год журнала: 2023, Номер 1(3), С. 208 - 225

Опубликована: Фев. 2, 2023

Oral administration is a widespread and convenient drug delivery approach. However, oral can be affected by the complex digestive tract environment, including irregular tissue morphology, presence of enzymes, mucus mucosal barriers, spatiotemporal variance in physiological parameters. These obstacles prevent many therapeutics. To overcome these challenges, devices designed with bioinspired compositions, structures or functions to make more drugs available for administration. Various have been developed harnessing biological materials living microorganisms, imitating functions. In this Review, we discuss design modification devices, examining engineering strategies target specific tissues applications. We highlight how key bottlenecks addressed through designs, concluding an outlook on remaining challenges towards clinical translation devices. commonly used strategy deliver harsh environment prevents negatively affect efficacy. This Review discusses microorganisms into that associated delivery.

Язык: Английский

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Oral microsphere formulation of M2 macrophage-mimetic Janus nanomotor for targeted therapy of ulcerative colitis

Science Advances, Год журнала: 2024, Номер 10(26)

Опубликована: Июнь 28, 2024

Oral medication for ulcerative colitis (UC) is often hindered by challenges such as inadequate accumulation, limited penetration of mucus barriers, and the intricate task mitigating excessive ROS inflammatory cytokines. Here, we present a strategy involving sodium alginate microspheres (SAMs) incorporating M2 macrophage membrane (M2M)-coated Janus nanomotors (denominated Motor@M2M) targeted treatment UC. SAM provides protective barrier, ensuring that Motor@M2M withstands harsh gastric milieu exhibits controlled release. M2M enhances targeting precision to tissues acts decoy neutralization Catalytic decomposition H

Язык: Английский

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Microfluidic-based multifunctional microspheres for enhanced oral co-delivery of probiotics and postbiotics

Biomaterials, Год журнала: 2024, Номер 308, С. 122564 - 122564

Опубликована: Апрель 3, 2024

Язык: Английский

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Microbiota-derived IPA alleviates intestinal mucosal inflammation through upregulating Th1/Th17 cell apoptosis in inflammatory bowel disease

Gut Microbes, Год журнала: 2025, Номер 17(1)

Опубликована: Фев. 16, 2025

The gut microbiota-derived metabolite indole-3-propionic acid (IPA) plays an important role in maintaining intestinal mucosal homeostasis, while the molecular mechanisms underlying IPA regulation on CD4+ T cell functions inflammatory bowel disease (IBD) remain elusive. Here we investigated roles of modulating cells and its therapeutic potential treatment human IBD. Leveraging metabolomics microbial community analyses, observed that levels IPA-producing microbiota (e.g. Peptostreptococcus, Clostridium, Fournierella) were decreased, IPA-consuming Parabacteroides, Erysipelatoclostridium, Lachnoclostridium) increased feces IBD patients than those healthy donors. Dextran sulfate sodium (DSS)-induced acute colitis CD45RBhighCD4+ transfer-induced chronic models then established mice treated orally with to study inflammation vivo. We found oral administration attenuated both mice, as characterized by body weight, reduced pro-inflammatory cytokines TNF-α, IFN-γ, IL-17A) histological scores colon. further utilized RNA sequencing, docking simulations, surface plasmon resonance analyses identified exerts biological effects interacting heat shock protein 70 (HSP70), leading inducing Th1/Th17 apoptosis. Consistently, ectopic expression HSP70 conferred resistance IPA-induced Therefore, these findings identify a previously unrecognized pathway which modulates provide promising avenue for

Язык: Английский

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Advances in chitosan-based microcapsules and their applications

Carbohydrate Polymers, Год журнала: 2022, Номер 300, С. 120265 - 120265

Опубликована: Окт. 26, 2022

Язык: Английский

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Prebiotics and Postbiotics Synergistic Delivery Microcapsules from Microfluidics for Treating Colitis

Advanced Science, Год журнала: 2022, Номер 9(16)

Опубликована: Апрель 11, 2022

Abstract Manipulation of gut microbiota by bacterial metabolites has shown protective effects against colitis; while the efficacy is strictly limited poor oral delivery efficiency and single drug usage. Here, a novel prebiotics postbiotics synergistic microcapsule composed indole‐3‐propionic acid (IPA) postbiotic three including alginate sodium, resistant starch (RS), chitosan via microfluidic electrospray for preventing treating colitis are proposed. It found that administration IPA microcapsules (IPA@MC) to mice can exert significant colitis, suggesting therapeutic synergy between postbiotics. Furthermore, mechanism IPA@MC revealed in modulating microbiota, significantly increasing overall richness abundance short‐chain fatty acids (SCFA) producing bacteria such as Faecalibacterium Roseburia . These results indicate ideal candidates colitis.

Язык: Английский

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Application of Biomedical Microspheres in Wound Healing

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7319 - 7319

Опубликована: Апрель 15, 2023

Tissue injury, one of the most common traumatic injuries in daily life, easily leads to secondary wound infections. To promote healing and reduce scarring, various kinds dressings, such as gauze, bandages, sponges, patches, microspheres, have been developed for healing. Among them, microsphere-based tissue dressings attracted increasing attention due advantage easy fabricate, excellent physicochemical performance superior drug release ability. In this review, we first introduced methods microspheres preparation, emulsification-solvent method, electrospray microfluidic technology well phase separation methods. Next, summarized biomaterials fabrication including natural polymers synthetic polymers. Then, presented application from different processing other applications. Finally, analyzed limitations discussed future development direction future.

Язык: Английский

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Fecal fermentation and high-fat diet-induced obesity mouse model confirmed exopolysaccharide from Weissella cibaria PFY06 can ameliorate obesity by regulating the gut microbiota

Carbohydrate Polymers, Год журнала: 2023, Номер 318, С. 121122 - 121122

Опубликована: Июнь 15, 2023

Язык: Английский

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Recent progress on engineered micro/nanomaterials mediated modulation of gut microbiota for treating inflammatory bowel disease

Journal of Controlled Release, Год журнала: 2024, Номер 370, С. 43 - 65

Опубликована: Апрель 17, 2024

Язык: Английский

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Exploring the Potential of Postbiotics for Food Safety and Human Health Improvement

Journal of Nutrition and Metabolism, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

Food safety is a global concern, with millions suffering from foodborne diseases annually. The World Health Organization (WHO) reports significant morbidity and mortality associated contaminated food consumption, this emphasizes the critical need for comprehensive measures. Recent attention has turned to postbiotics, metabolic byproducts of probiotics, as potential agents enhancing safety. Postbiotics, including organic acids, enzymes, bacteriocins, exhibit antimicrobial antioxidant properties that do not require live organisms, offers advantages over probiotics. This literature review critically examines role postbiotics in gut microbiome modulation applications industry. Through an extensive existing literature, study evaluates impact on composition their functional ingredients. Research indicates are effective inhibiting pathogens such

Язык: Английский

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