Cell Proliferation,
Год журнала:
2024,
Номер
57(6)
Опубликована: Янв. 14, 2024
Abstract
Since
its
discovery
in
1978,
cisplatin‐based
chemotherapy
regimens
have
served
a
pivotal
role
human
cancer
treatment,
saving
millions
of
lives.
However,
high
risk
still
poses
significant
challenge
for
cisplatin‐induced
acute
kidney
injury
(AKI),
which
occurs
30%
cisplatin‐treated
patients.
Unfortunately,
no
effective
solution
preventing
or
managing
this
severe
complication,
greatly
impacts
clinical
administration.
Kidney
is
the
main
organ
injured
by
cisplatin,
and
related
to
cell
apoptosis
DNA
injury.
Therefore,
achieve
safe
use
cisplatin
tumour
key
lies
identifying
treatment
that
can
effectively
minimize
nephrotoxicity.
Here,
we
successfully
synthesized
applied
DNA‐nanostructure
complex,
named
TFG,
contains
tetrahedral
framework
nucleic
acids
(tFNAs)
FG‐4592,
novel
Hif‐1α
inducer.
As
cargo,
TFG
composed
entirely
strands.
It
possesses
low
nephrotoxicity
renal
aggregation
properties
while
FG‐4592
able
relieve
downregulating
signal
pathways.
And
it
when
taken
treatment.
This
work
aims
enhance
protection
patients
using
DNA‐based
nanomedicines
kidney.
has
potential
revolutionize
diseases,
particularly
drug‐induced
injury,
leading
improved
outcomes.
Cell Proliferation,
Год журнала:
2023,
Номер
56(8)
Опубликована: Фев. 17, 2023
Sepsis
is
a
highly
lethal
condition
and
caused
by
the
dysregulation
of
body's
immune
response
to
infection.
Indeed,
sepsis
remains
leading
cause
death
in
severely
ill
patients,
currently,
no
effective
treatment
available.
Pyroptosis,
which
mainly
activated
cytoplasmic
danger
signals
eventually
promote
release
pro-inflammatory
factors,
newly
discovered
programmed
cell
procedure
that
clears
infected
cells
while
simultaneously
triggering
an
inflammatory
response.
Increasing
evidence
indicates
pyroptosis
participates
development
sepsis.
As
novel
DNA
nanomaterial,
tetrahedral
framework
nucleic
acids
(tFNAs)
characterized
its
unique
spatial
structure,
possess
excellent
biosafety
profile
can
quickly
enter
impart
anti-inflammatory
anti-oxidation
effects.
In
this
study,
roles
tFNAs
vitro
model
macrophage
vivo
septic
mice
were
examined,
it
was
found
could
mitigate
organ
damage
mice,
wherein
they
reduced
factor
levels
inhibiting
pyroptosis.
These
results
provide
possible
new
strategies
for
future
ACS Nano,
Год журнала:
2023,
Номер
17(22), С. 22334 - 22354
Опубликована: Окт. 2, 2023
As
a
major
late
complication
of
diabetes,
diabetic
peripheral
neuropathy
(DPN)
is
the
primary
reason
for
amputation.
Nevertheless,
there
are
no
wonder
drugs
available.
Regulating
dysfunctional
mitochondria
key
therapeutic
target
DPN.
Resveratrol
(RSV)
widely
proven
to
guard
mitochondria,
yet
unsatisfactory
bioavailability
restricts
its
clinical
application.
Tetrahedral
framework
nucleic
acids
(tFNAs)
promising
carriers
due
their
excellent
cell
entrance
efficiency,
biological
safety,
and
structure
editability.
Here,
RSV
was
intercalated
into
tFNAs
form
tFNAs-RSV
complexes.
achieved
enhanced
stability,
bioavailability,
biocompatibility
compared
with
alone.
With
treatment,
reactive
oxygen
species
(ROS)
production
minimized
reductases
were
activated
in
an
vitro
model
Besides,
respiratory
function
adenosine
triphosphate
(ATP)
enhanced.
also
exhibited
favorable
effects
on
sensory
dysfunction,
neurovascular
deterioration,
demyelination,
neuroapoptosis
DPN
mice.
Metabolomics
analysis
revealed
that
redox
regulation
energy
metabolism
two
principal
mechanisms
impacted
during
process.
Comprehensive
inspections
indicated
inhibited
nitrosation
oxidation
reductase
chain.
In
sum,
served
as
mitochondrial
nanoguard
(mito-guard),
representing
viable
drilling
drug
development
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(37), С. 43359 - 43373
Опубликована: Сен. 6, 2023
Antibody
drug
conjugates
(ADCs)
have
shown
promise
to
be
the
mainstream
chemotherapeutics
for
advanced
HER2-positive
cancers,
yet
issues
of
poor
delivery
efficiency,
limited
chemotherapeutic
effects,
severe
immune
responses,
and
resistance
remain
addressed
before
clinical
applications
ADCs.
The
DNA
aptamer-guided
(ApDCs)
are
receiving
growing
attention
specific
tumors
due
their
excellent
tumor
affinity
low
cost.
Therefore,
developing
a
multivalent
ApDC
nanomedicine
by
combining
anti-HER2
aptamer
(HApt),
tetrahedral
framework
nucleic
acid
(tFNA),
deruxtecan
(Dxd)
together
form
HApt-tFNA@Dxd
might
help
address
these
concerns.
In
this
study,
HER2-targeted
modified
tetrahedron
(HApt-tFNA)
was
employed
as
system
delivery,
adoption
tFNA
could
effectively
enlarge
drug-loading
rate
compared
ApDCs
previously
reported.
Compared
with
free
Dxd
tFNA@Dxd,
showed
better
structural
stability,
targeted
cytotoxicity
gastric
cancer,
increased
tissue
aggregation
ability
in
tumors.
These
features
superiorities
make
promising
medicine
Our
work
developed
new
targeting
nanomaterials
agents,
which
represents
critical
advance
toward
novel
DNA-based
promoting
potential
cancer
therapy.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(11)
Опубликована: Янв. 5, 2023
Abstract
Bladder
outlet
obstruction
(BOO)
is
a
prevalent
condition
arising
from
urethral
stricture,
posterior
valves,
and
benign
prostatic
hyperplasia.
Long‐term
can
lead
to
bladder
remodeling,
which
characterized
by
inflammatory
cell
infiltration,
detrusor
hypertrophy,
fibrosis.
Until
now,
there
are
no
efficacious
therapeutic
options
for
BOO‐induced
remodeling.
Tetrahedral
framework
nucleic
acids
(tFNAs)
type
of
novel
3D
DNA
nanomaterials
that
possess
excellent
antifibrotic
effects.
Here,
determine
the
treatment
effects
tFNAs
on
remodeling
aimed.
Four
single‐strand
DNAs
self‐assembled
form
tetrahedral
nanostructures,
investigated
in
an
vivo
BOO
animal
model
vitro
transforming
growth
factor
beta1
(TGF‐
β
1)‐induced
fibrosis
model.
The
results
demonstrated
could
ameliorate
dysfunction
inhibiting
M2
macrophage
polarization
macrophage–myofibroblast
transition
(MMT)
process.
Furthermore,
regulate
MMT
process
deactivating
signal
transducer
activator
transcription
(Stat)
TGF‐
1/small
mothers
against
decapentaplegic
(Smad)
pathways,
respectively.
This
first
study
reveal
might
be
promising
nanomaterial
Cell Proliferation,
Год журнала:
2024,
Номер
57(6)
Опубликована: Янв. 14, 2024
Abstract
Since
its
discovery
in
1978,
cisplatin‐based
chemotherapy
regimens
have
served
a
pivotal
role
human
cancer
treatment,
saving
millions
of
lives.
However,
high
risk
still
poses
significant
challenge
for
cisplatin‐induced
acute
kidney
injury
(AKI),
which
occurs
30%
cisplatin‐treated
patients.
Unfortunately,
no
effective
solution
preventing
or
managing
this
severe
complication,
greatly
impacts
clinical
administration.
Kidney
is
the
main
organ
injured
by
cisplatin,
and
related
to
cell
apoptosis
DNA
injury.
Therefore,
achieve
safe
use
cisplatin
tumour
key
lies
identifying
treatment
that
can
effectively
minimize
nephrotoxicity.
Here,
we
successfully
synthesized
applied
DNA‐nanostructure
complex,
named
TFG,
contains
tetrahedral
framework
nucleic
acids
(tFNAs)
FG‐4592,
novel
Hif‐1α
inducer.
As
cargo,
TFG
composed
entirely
strands.
It
possesses
low
nephrotoxicity
renal
aggregation
properties
while
FG‐4592
able
relieve
downregulating
signal
pathways.
And
it
when
taken
treatment.
This
work
aims
enhance
protection
patients
using
DNA‐based
nanomedicines
kidney.
has
potential
revolutionize
diseases,
particularly
drug‐induced
injury,
leading
improved
outcomes.
