Macromolecular Materials and Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 14, 2025
Abstract
In
recent
times,
the
integration
of
nanomaterials
into
3D
biofabricated
structures
has
become
a
transformative
approach
in
advancing
biomedical
field.
Nanomaterials
exhibit
distinctive
properties
such
as
superior
mechanical
strength,
enhanced
biocompatibility,
and
improved
drug
delivery
efficiency,
making
them
well‐suited
for
use.
This
comprehensive
review
explores
synergistic
potential
combining
nanomaterials—such
metallic,
carbon‐based,
ceramic,
polymeric
nanoparticles—with
advanced
biofabrication
techniques,
including
bioprinting,
melt
electrowriting,
electrospinning.
These
integrations
have
demonstrated
significant
promise
diverse
applications,
regeneration
nerve,
bone,
cardiac
tissues,
wound
healing,
cancer
therapy.
Despite
substantial
progress,
several
challenges
hinder
clinical
translation,
difficulties
achieving
precise
nanomaterial
integration,
biocompatibility
toxicity
concerns,
scalability
manufacturing,
regulatory
complexities.
synthesizes
advancements,
evaluates
existing
challenges,
identifies
key
research
directions
to
address
these
obstacles.
It
highlights
significance
interdisciplinary
collaboration
maximizing
nanomaterial‐integrated
promoting
innovative
advancements
science
healthcare.
IGI Global eBooks,
Год журнала:
2025,
Номер
unknown, С. 327 - 380
Опубликована: Апрель 11, 2025
Polymeric
nanofibers
are
revolutionizing
biomedical
engineering
and
environmental
sustainability
due
to
their
highly
unique
properties
such
as
a
high
surface
area
volume
ratio,
an
ability
modulate
pore
size,
mechanical
flexibility.
Nanofibers
mimic
extracellular
matrix
structures
aid
tissue
engineering,
regenerative
medicine,
provide
targeted
drug
delivery,
localized
treatments
of
cancer
infections.
Further
advances
in
the
diagnostic
field,
including
disease
diagnostics
biosensors,
further
demonstrate
potential
these
substrates.
environmentally
beneficial
by
enhancing
filtration
air
water,
pollutant
degradation,
renewable
energy
systems
solar
cells
batteries.
Scalability,
cost,
recyclability
continue
present
challenges,
thus
eco-friendly
approaches
interdisciplinary
cooperation
is
required.
AI
machine
learning
integration
future
promises
optimized
production
broader
applications
serve
critical
societal
challenges.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 29, 2025
Abstract
Spinal
cord
injury
(SCI)
is
a
debilitating
condition
that
leads
to
severe
disabilities
and
imposes
significant
economic
social
burdens.
Current
therapeutic
strategies
primarily
focus
on
symptom
management,
with
limited
success
in
promoting
full
neurological
recovery.
In
response
this
challenge,
the
design
of
novel
guidance
conduits
incorporating
multiple
gradient
cues,
inspired
reported
by
biological
processes,
enhance
spinal
repair.
These
are
fabricated
using
electrospinning
masked
coaxial
electrospraying,
simple
yet
effective
method
integrates
topological,
haptotactic,
chemotactic
cues
into
single
scaffold.
The
synergy
these
significantly
promoted
cell
migration,
neural
stem
differentiation
neurons,
axonal
extension,
resulting
substantial
improvements
regeneration
functional
recovery
rat
model.
Single‐nucleus
RNA
sequencing
further
demonstrated
conduit
inhibited
fibroblast
proliferation,
preserved
microglial
homeostasis,
restored
cellular
proportions,
facilitated
neuronal
axons,
dendrites,
synapses.
This
work
presents
an
innovative,
versatile
platform
for
fabricating
tissue
scaffolds
integrate
offering
promising
strategy
SCI
treatment
broader
applications.
Macromolecular Materials and Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 14, 2025
Abstract
In
recent
times,
the
integration
of
nanomaterials
into
3D
biofabricated
structures
has
become
a
transformative
approach
in
advancing
biomedical
field.
Nanomaterials
exhibit
distinctive
properties
such
as
superior
mechanical
strength,
enhanced
biocompatibility,
and
improved
drug
delivery
efficiency,
making
them
well‐suited
for
use.
This
comprehensive
review
explores
synergistic
potential
combining
nanomaterials—such
metallic,
carbon‐based,
ceramic,
polymeric
nanoparticles—with
advanced
biofabrication
techniques,
including
bioprinting,
melt
electrowriting,
electrospinning.
These
integrations
have
demonstrated
significant
promise
diverse
applications,
regeneration
nerve,
bone,
cardiac
tissues,
wound
healing,
cancer
therapy.
Despite
substantial
progress,
several
challenges
hinder
clinical
translation,
difficulties
achieving
precise
nanomaterial
integration,
biocompatibility
toxicity
concerns,
scalability
manufacturing,
regulatory
complexities.
synthesizes
advancements,
evaluates
existing
challenges,
identifies
key
research
directions
to
address
these
obstacles.
It
highlights
significance
interdisciplinary
collaboration
maximizing
nanomaterial‐integrated
promoting
innovative
advancements
science
healthcare.
