Reproductive Biology and Endocrinology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 7, 2024
Mesenchymal
stem
cells
(MSCs)
have
shown
potential
in
repairing
chemotherapy-induced
premature
ovarian
failure
(POF).
However,
challenges
such
as
cell
loss
and
immune
phagocytosis
post-transplantation
hinder
their
application.
Due
to
easy
safe
handling,
vitro
culture
is
widely
available
for
drug
screening,
pathophysiological
research,
fertilization.
MSCs
could
exhibit
therapeutic
capacity
injury,
avoid
tissue
system.
Therefore,
this
study
utilizes
an
system
investigate
the
reparative
of
human
umbilical
cord
mesenchymal
(hUCMSCs)
mechanism.
Stem Cell Research & Therapy,
Год журнала:
2023,
Номер
14(1)
Опубликована: Сен. 4, 2023
Abstract
Although
mesenchymal
stem
cell
(MSC)
transplantation
provides
an
alternative
strategy
for
end-stage
liver
disease
(ESLD),
further
widespread
application
of
MSC
therapy
is
limited
owing
to
low
engraftment
efficiency.
Improving
efficiency
plays
a
critical
role
in
enhancing
diseases.
In
this
review,
we
summarize
the
current
status
and
challenges
ESLD.
We
also
outline
complicated
cell-homing
process
highlight
how
closely
related
huge
differences
extracellular
conditions
involved
homing
journeys
ranging
from
constant,
controlled
vitro
variable
challenging
vivo.
survival
capabilities
enhances
efficacy.
Therefore,
strategies,
including
hypoxic
priming,
drug
pretreatment,
gene
modification,
cytokine
as
well
splenectomy
local
irradiation,
used
improve
capability,
enhance
therapeutic
therapy.
hope
that
review
will
provide
new
insights
into
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(9), С. 3983 - 4000
Опубликована: Май 13, 2024
With
the
escalating
prevalence
of
global
heat
waves,
stroke
has
become
a
prominent
health
concern,
leading
to
substantial
liver
damage.
Unlike
other
forms
injury,
stroke-induced
damage
is
characterized
by
cytotoxicity
and
heightened
inflammation,
directly
contributing
elevated
mortality
rates.
While
clinical
assessments
have
identified
bilirubin
levels
as
indicative
Kupffer
cell
dysfunction,
their
specific
correlation
with
injury
remains
unclear.
Our
hypothesis
proposes
involvement
ferroptosis
during
stroke,
initiating
IL-1
Abstract
Mesenchymal
stromal
cell
(MSC)
implantation
is
a
promising
option
for
liver
repair,
but
their
poor
retention
in
the
injured
milieu
critically
blunts
therapeutic
effects.
The
aim
to
clarify
mechanisms
underlying
massive
MSC
loss
post‐implantation
and
establish
corresponding
improvement
strategies.
primarily
occurs
within
initial
hours
after
into
or
under
reactive
oxygen
species
(ROS)
stress.
Surprisingly,
ferroptosis
identified
as
culprit
rapid
depletion.
In
ferroptosis‐
ROS‐provoking
MSCs,
branched‐chain
amino
acid
transaminase‐1
(BCAT1)
dramatically
decreased,
its
downregulation
renders
susceptible
via
suppressing
transcription
of
glutathione
peroxidase‐4
(GPX4),
vital
defensing
enzyme.
BCAT1
impedes
GPX4
rapid‐responsive
metabolism‐epigenetics
coordinating
mechanism,
involving
α
‐ketoglutarate
accumulation,
histone
3
lysine
9
trimethylation
loss,
early
growth
response
protein‐1
upregulation.
Approaches
suppress
(e.g.,
incorporating
inhibitors
injection
solvent
overexpressing
BCAT1)
significantly
improve
liver‐protective
effects
post‐implantation.
This
study
provides
first
evidence
indicating
that
excessive
nonnegligible
depletion
insufficient
efficacy
milieu.
Strategies
are
conducive
optimizing
MSC‐based
therapy.
Stem Cell Research & Therapy,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 4, 2025
Abstract
Type
1
diabetes
mellitus
(T1DM)
is
characterized
by
progressive
β-cell
death,
leading
to
loss
and
insufficient
insulin
secretion.
Mesenchymal
stem
cells
(MSCs)
transplantation
currently
one
of
the
most
promising
methods
for
replacement
therapy.
However,
recent
studies
have
shown
that
ferroptosis
not
only
key
mechanisms
but
also
reasons
extensive
cell
death
within
a
short
period
time
after
MSCs
transplantation.
Ferroptosis
new
type
regulated
(RCD)
iron-dependent
accumulation
lipid
peroxides.
Due
weak
antioxidant
capacity
β-cells,
they
are
susceptible
cytotoxic
stimuli
such
as
oxidative
stress
(OS),
therefore
ferroptosis.
Transplanted
extremely
perturbations
in
their
microenvironment,
especially
OS,
which
can
weaken
induce
through
In
pathophysiological
process
T1DM,
large
amount
reactive
oxygen
species
(ROS)
produced,
causing
OS.
Therefore,
targeting
may
be
way
protect
β-cells
improve
therapeutic
effect
This
review
reviews
research
related
MSCs,
summarizes
developed
strategies
help
inhibit
study
aims
understand
mechanism
transplantation,
emphasize
importance
protecting
improving
survival
function
transplanted
provide
direction
therapy
T1DM
future.
