Biomaterials, Год журнала: 2025, Номер unknown, С. 123335 - 123335
Опубликована: Апрель 1, 2025
Язык: Английский
Biomaterials, Год журнала: 2025, Номер 317, С. 123094 - 123094
Опубликована: Янв. 7, 2025
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Фев. 5, 2025
Immunotherapy has revolutionized cancer treatment, offering hope for patients with otherwise treatment-resistant tumors. Among the most promising approaches are cellular therapies, particularly chimeric antigen receptor T-cell (CAR-T) therapy, which shown remarkable success in hematologic malignancies. However, application of these therapies to solid tumors, such as lung and colorectal cancers, faced significant challenges. Tumor resistance mechanisms—ranging from immune evasion, loss, checkpoint upregulation, tumor microenvironment immunosuppression—remain major obstacles. This mini-review highlights latest advancements immunotherapy, a focus on addresses mechanisms that hinder their effectiveness cancers. We examine evolution CAR-T cell well potential engineered natural killer (NK) cells macrophages treatment. The review also explores cutting-edge strategies aimed at overcoming resistance, including combination gene editing technologies, nanotechnology targeted drug delivery. By discussing molecular, cellular, microenvironmental factors contributing we aim provide comprehensive overview how challenges can be overcome, paving way more effective, personalized immunotherapies
Язык: Английский
Процитировано
0
Highlights in Science Engineering and Technology, Год журнала: 2025, Номер 125, С. 271 - 277
Опубликована: Фев. 18, 2025
Cancer is one of the diseases with highest mortality rates in world today, and cancer itself very difficult to treat. Among these, breast lung are exceptionally severe types cancer. The complexity, heterogeneity, drug resistance, immune evasion present enormous challenges for doctors scientists. In recent decades, scientists have explored various methods tackle Although progress has been made, treating remains challenging. Using nanocarriers deliver drugs targeted therapy an effective treatment method. However, nanoparticle-based therapies encounter issues such as targeting selectivity, biocompatibility, safety concerns. Liposomes, a type encased lipid bilayers that encapsulate pharmaceuticals, exhibit their advantages among plethora carriers. Liposomes possess characteristics multiple capabilities, high bioavailability, elevated safety. At present, it emerged nanocarrier combating cancers, including This article will focus on liposomes therapeutic efficacy
Язык: Английский
Процитировано
0
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 4201 - 4234
Опубликована: Апрель 1, 2025
Although immunotherapy has made significant progress in cancer treatment, its limited responsiveness greatly hindered widespread clinical application. The Warburg effect tumor cells creates a microenvironment (TME) characterized by hypoxia, low glucose levels, and high lactate which severely inhibits the antitumor immune response. Consequently, targeting metabolism to reprogram TME is considered an effective strategy for reversing immunosuppression evasion. Numerous studies have been conducted on enhancing efficacy through delivery of modulators via nanocarriers. This review provides comprehensive overview metabolic characteristics tumors their impacts system, as well nanodelivery strategies enhance immunotherapy. These include inhibiting key glycolytic enzymes, blocking transporters, utilizing oxidase oxidase. Furthermore, this article reviews recent advancements synergistic therapy involving metabolism-targeted combined with other treatments, such chemotherapy, radiotherapy (RT), phototherapy, Finally, we discuss limitations future prospects nanotechnology therapy, hoping provide new directions ideas improve
Язык: Английский
Процитировано
0
Biomaterials, Год журнала: 2025, Номер unknown, С. 123335 - 123335
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0