Riboflavin for women’s health and emerging microbiome strategies

npj Biofilms and Microbiomes, Год журнала: 2024, Номер 10(1)

Опубликована: Окт. 18, 2024

Riboflavin (vitamin B2) is an essential water-soluble vitamin that serves as a precursor of flavin mononucleotide (FMN) and adenine dinucleotide (FAD). FMN FAD are coenzymes involved in key enzymatic reactions energy metabolism, biosynthesis, detoxification electron scavenging pathways. deficiency prevalent worldwide impacts women's health due to riboflavin demands linked urogenital reproductive health, hormonal fluctuations during the menstrual cycle, pregnancy, breastfeeding. Innovative functional foods nutraceuticals increasingly developed meet needs supplement dietary sources. An emerging particularly promising strategy administration riboflavin-producing lactic acid bacteria, combining benefits with those probiotics situ production. Specific taxa lactobacilli particular interest for women, because crucial role Lactobacillus species vagina documented effects other Lactobacillaceae gut on skin. In this narrative review, we synthesize underlying molecular mechanisms clinical intake evaluate synergistic potential microbiota.

Язык: Английский

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Schisandrin A Alleviates Spatial Learning and Memory Impairment in Diabetic Rats by Inhibiting Inflammatory Response and Through Modulation of the PI3K/AKT Pathway

Molecular Neurobiology, Год журнала: 2023, Номер 61(5), С. 2514 - 2529

Опубликована: Ноя. 1, 2023

Язык: Английский

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ABBV-744 alleviates LPS-induced neuroinflammation via regulation of BATF2-IRF4-STAT1/3/5 axis

Acta Pharmacologica Sinica, Год журнала: 2024, Номер unknown

Опубликована: Июнь 11, 2024

Язык: Английский

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Integrative transcriptome-proteome approach reveals key hypoxia-related features involved in the neuroprotective effects of Yang Xue oral liquid on Alzheimer’s and Parkinson’s disease

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июль 9, 2024

Introduction: This study investigates the role of hypoxia-related genes in neuroprotective efficacy Yang Xue oral liquid (YXKFY) Alzheimer’s disease (AD) and Parkinson’s (PD). Methods results: Using differential expression weighted gene co-expression network analysis (WGCNA), we identified 106 9 hypoxia-associated AD PD, respectively, that are implicated transcriptomic proteomic profiles. An artificial intelligence-driven hypoxia signature (AIDHS), comprising 17 3 for was developed validated across nine independent cohorts ( n = 1713), integrating 10 machine learning algorithms 113 algorithmic combinations. Significant associations were observed between AIDHS markers immune cells including naive CD4 + T cells, macrophages, neutrophils. Interactions with miRNAs (hsa-miR-1, hsa-miR-124) transcription factors (USF1) also identified. Single-cell RNA sequencing (scRNA-seq) data highlighted distinct patterns various cell types, such as high TGM2 endothelial PDGFRB mesenchymal SYK microglia. YXKFY treatment shown to repair cellular damage decrease reactive oxygen species (ROS) levels. Notably, previously dysfunctional expression, FKBPL, TGM2, PPIL1, BLVRB, PDGFRB, exhibited significant recovery after treatment, associated riboflavin lysicamine. Conclusion: The above suggested be central neuroinflammation responses potential key mediators YXKFY’s action.

Язык: Английский

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Association between vitamin B2 intake and cognitive performance among older adults: a cross-sectional study from NHANES

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 20, 2024

Язык: Английский

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