Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 15, 2025
Endometrial
cancer
ranks
among
the
most
common
gynecological
cancers,
with
increasing
rates
of
incidence
and
death.
Cold
atmospheric
plasma
(CAP)
has
become
a
promising
novel
therapeutic
approach
for
treatment.
Nevertheless,
specific
impact
CAP
on
endometrial
remains
inadequately
characterized.
This
study
aimed
to
investigate
effect
progression
reveal
its
regulatory
mechanisms.
Colony
formation,
EdU,
wound-healing,
transwell
assay
were
used
detect
progression.
Proteomics
is
employed
identify
potential
targets
signaling
pathways
through
which
impacts
cells.
MDA,
lipid
ROS,
JC-1
MMP
assays
ferroptosis.
Immunoprecipitation-mass
spectrometry,
co-immunoprecipitation,
immunofluorescence
co-localization,
molecular
docking
analyze
USP49
HDAC3
interactions.
The
tumor
xenografts
model
determined
that
inhibits
growth
in
vivo.
observed
significant
inhibitory
proliferation
migration
cells
reported
first
time
induces
ferroptosis
Mechanistically,
activated
transcription
p53
by
modulating
mediated
histone
H3K18
lactylation,
resulting
upregulation
driving
cell
interaction
between
was
validated
mass
spectrometry
co-immunoprecipitation
experiments.
regulation
contingent
upon
USP49,
wherein
down-regulation
augments
ubiquitination
HDAC3,
consequently
diminishing
protein
stability.
Furthermore,
animal
models
transplanted
tumors
corroborated
Our
findings
illustrate
suppressive
treatment
uncover
mechanism
CAP.
Specifically,
modulates
pathway
HDAC3/H3K18la/p53
axis,
presenting
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Март 8, 2024
Ferroptosis
is
a
non-apoptotic
form
of
regulated
cell
death
characterized
by
the
lethal
accumulation
iron-dependent
membrane-localized
lipid
peroxides.
It
acts
as
an
innate
tumor
suppressor
mechanism
and
participates
in
biological
processes
tumors.
Intriguingly,
mesenchymal
dedifferentiated
cancer
cells,
which
are
usually
resistant
to
apoptosis
traditional
therapies,
exquisitely
vulnerable
ferroptosis,
further
underscoring
its
potential
treatment
approach
for
cancers,
especially
refractory
cancers.
However,
impact
ferroptosis
on
extends
beyond
direct
cytotoxic
effect
cells.
induction
not
only
inhibits
but
also
promotes
development
due
negative
anticancer
immunity.
Thus,
comprehensive
understanding
role
crucial
successful
translation
therapy
from
laboratory
clinical
applications.
In
this
review,
we
provide
overview
recent
advancements
cancer,
covering
molecular
mechanisms,
functions,
regulatory
pathways,
interactions
with
microenvironment.
We
summarize
applications
immunotherapy,
radiotherapy,
systemic
therapy,
well
inhibition
various
conditions.
finally
discuss
markers,
current
challenges
future
directions
cancer.
Abstract
Malignant
ascites
in
advanced
hepatocellular
carcinoma
(HCC)
is
a
complex
clinical
problem
that
lacks
effective
treatments.
Due
to
the
insensitivity
of
HCC
cells
traditional
chemotherapies,
low
drug
accumulation,
and
limited
residence
time
peritoneal
cavity,
therapeutic
effects
malignant
are
not
satisfactory.
In
this
study,
an
injectable
hydrogel
delivery
system
based
on
chitosan
hydrochloride
oxidized
dextran
(CH‐OD)
designed
load
sulfasalazine
(SSZ),
FDA‐approved
with
ferroptosis‐inducing
ability,
for
tumor‐killing
activation
anti‐tumor
immunity.
Compared
free
SSZ,
SSZ‐loaded
CH‐OD
(CH‐OD‐SSZ)
exhibits
greater
cytotoxicity
induces
higher
levels
immunogenic
ferroptosis.
preclinical
model
hepatoma
ascites,
intraperitoneal
administration
CH‐OD‐SSZ
can
significantly
suppress
tumor
progression
improve
immune
landscape.
Both
vitro
vivo,
repolarization
macrophages
M1‐like
phenotype
promotes
maturation
dendritic
cells.
Combination
treatment
anti‐programmed
cell
death
protein
1
(PD‐1)
immunotherapy
achieves
more
than
50%
regression
generates
long‐term
memory.
Collectively,
promising
potential
dissemination
HCC,
especially
when
combined
anti‐PD‐1
immunotherapy.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Окт. 18, 2024
Immunotherapy
has
made
significant
strides
in
cancer
treatment,
particularly
through
immune
checkpoint
blockade
(ICB),
which
shown
notable
clinical
benefits
across
various
tumor
types.
Despite
the
transformative
impact
of
ICB
treatment
therapy,
only
a
minority
patients
exhibit
positive
response
to
it.
In
with
solid
tumors,
those
who
respond
well
typically
demonstrate
an
active
profile
referred
as
"hot"
(immune-inflamed)
phenotype.
On
other
hand,
non-responsive
may
distinct
"cold"
(immune-desert)
phenotype,
differing
from
features
tumors.
Additionally,
there
is
more
nuanced
"excluded"
positioned
between
and
categories,
known
type.
Effective
differentiation
understanding
intrinsic
factors,
characteristics,
TME,
external
factors
are
critical
for
predicting
results.
It
widely
accepted
that
therapy
exerts
profound
effect
on
limited
efficacy
against
or
"altered"
necessitating
combinations
therapeutic
modalities
enhance
cell
infiltration
into
tissue
convert
tumors
ones.
Therefore,
aligning
traits
this
review
systematically
delineates
respective
influencing
extensively
discusses
varied
approaches
drug
targets
based
assess
efficacy.
Advanced Materials,
Год журнала:
2024,
Номер
36(21)
Опубликована: Фев. 16, 2024
Immunotherapy
represents
a
revolutionary
paradigm
in
cancer
management,
showcasing
its
potential
to
impede
tumor
metastasis
and
recurrence.
Nonetheless,
challenges
including
limited
therapeutic
efficacy
severe
immune-related
side
effects
are
frequently
encountered,
especially
solid
tumors.
Hydrogels,
class
of
versatile
materials
featuring
well-hydrated
structures
widely
used
biomedicine,
offer
promising
platform
for
encapsulating
releasing
small
molecule
drugs,
biomacromolecules,
cells
controlled
manner.
Immunomodulatory
hydrogels
present
unique
capability
augmenting
immune
activation
mitigating
systemic
toxicity
through
encapsulation
multiple
components
localized
administration.
Notably,
based
on
biopolymers
have
gained
significant
interest
owing
their
biocompatibility,
environmental
friendliness,
ease
production.
This
review
delves
into
the
recent
advances
bio-based
immunotherapy
synergistic
combinatorial
approaches,
highlighting
diverse
applications.
It
is
anticipated
that
this
will
guide
rational
design
field
immunotherapy,
fostering
clinical
translation
ultimately
benefiting
patients.
Cancer Communications,
Год журнала:
2023,
Номер
43(10), С. 1071 - 1096
Опубликована: Сен. 17, 2023
The
advent
of
immunotherapy
has
significantly
reshaped
the
landscape
cancer
treatment,
greatly
enhancing
therapeutic
outcomes
for
multiple
types
cancer.
However,
only
a
small
subset
individuals
respond
to
it,
underscoring
urgent
need
new
methods
improve
its
response
rate.
Ferroptosis,
recently
discovered
form
programmed
cell
death,
emerged
as
promising
approach
anti-tumor
therapy,
with
targeting
ferroptosis
kill
tumors
seen
potentially
effective
strategy.
Numerous
studies
suggest
that
inducing
can
synergistically
enhance
effects
immunotherapy,
paving
way
combined
treatment
method
in
future.
Nevertheless,
recent
research
raised
concerns
about
potential
negative
impacts
on
immunity
consequence
ferroptosis,
leading
conflicting
views
within
scientific
community
interplay
between
and
immunity,
thereby
necessity
comprehensive
review
existing
literature
this
relationship.
Previous
reviews
have
touched
related
content,
many
focusing
primarily
promoting
role
while
overlooking
evidence
inhibitory
immunity.
Others
concentrated
solely
discussing
content
either
from
perspective
cells
or
immune
ferroptosis.
Given
both
exist
tumor
microenvironment,
one-sided
discussion
cannot
comprehensively
summarize
topic.
Therefore,
perspectives
tumor-infiltrating
cells,
we
systematically
current
intending
provide
explanations
identify
work
needed
establish
translational
basis
ferroptosis-targeted
therapy
treating
tumors.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(22)
Опубликована: Март 29, 2024
The
immune
checkpoint
blockade
strategy
has
improved
the
survival
rate
of
late-stage
lung
cancer
patients.
However,
low
response
limits
immunotherapy
efficiency.
Here,
we
report
a
ROS-responsive
Fe
Ferroptosis
is
a
nonapoptotic
form
of
cell
death
characterized
by
iron-dependent
lipid
peroxidation
in
membrane
phospholipids.
Since
its
identification
2012,
extensive
research
has
unveiled
involvement
the
pathophysiology
numerous
diseases,
including
cancers,
neurodegenerative
disorders,
organ
injuries,
infectious
autoimmune
conditions,
metabolic
and
skin
diseases.
Oxidizable
lipids,
overload
iron,
compromised
antioxidant
systems
are
known
as
critical
prerequisites
for
driving
overwhelming
peroxidation,
ultimately
leading
to
plasma
rupture
ferroptotic
death.
However,
precise
regulatory
networks
governing
ferroptosis
ferroptosis-targeted
therapy
these
diseases
remain
largely
undefined,
hindering
development
pharmacological
agonists
antagonists.
In
this
review,
we
first
elucidate
core
mechanisms
summarize
epigenetic
modifications
(e.g.,
histone
modifications,
DNA
methylation,
noncoding
RNAs,
N6-methyladenosine
modification)
nonepigenetic
genetic
mutations,
transcriptional
regulation,
posttranslational
modifications).
We
then
discuss
association
between
disease
pathogenesis
explore
therapeutic
approaches
targeting
ferroptosis.
also
introduce
potential
clinical
monitoring
strategies
Finally,
put
forward
several
unresolved
issues
which
progress
needed
better
understand
hope
review
will
offer
promise
application
therapies
context
human
health
disease.
