Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 17, 2025
The
complicated
environment
of
the
oral
cavity
presents
significant
challenges
to
traditional
antibacterial
approaches,
which
has
driven
exploration
novel
therapeutic
strategies.
Metal-based
nanomaterials
(MNMs),
with
diverse
mechanisms
(e.g.,
membrane
disruption,
oxidative
stress)
and
evolution
from
empirical
theory-guided
design,
exhibit
immense
potential.
This
review
introduces
pioneering
Hierarchical
Response
Strategy
Framework,
systematically
classifying
MNM
systems
into
three
progressive
levels:
Primary
category,
comprising
MNMs
that
exert
spontaneous
effects
based
on
inherent
physicochemical
properties
ion
release);
Secondary
including
precisely
controlled
actions
by
microenvironmental
or
stimulus-responsive
light-induced
ROS);
Tertiary
encompassing
integrate
regenerative
functions
for
multidimensional
therapy
remineralization).
Through
this
framework,
authors
elucidate
MNMs'
transition
single-function
precision-controlled,
multifunctional
synergy,
analyze
impact
metal
elements
structural
design
efficacy,
summarize
their
applications
in
dental
caries,
endodontic
infections,
periodontal
disease,
etc.
framework
offers
a
perspective
existing
research
theoretical
foundation
rational
next-generation
precise,
smart,
comprehensive
anti-infective
materials.
Coatings,
Год журнала:
2023,
Номер
14(1), С. 25 - 25
Опубликована: Дек. 25, 2023
Adsorbed
molecules
can
modulate
the
behavior
of
magnesium
(Mg)
and
Mg
alloy
in
biomedical
applications.
The
interaction
regularity
mechanism
biomolecules
(such
as
amino
acids,
dipeptides,
tripeptide)
on
a
Mg(0001)
surface,
influence
dipole
correction,
effects
alloying
elements
electronic
structure
were
investigated
this
study
using
first-principles
calculations.
Specifically,
adsorption
energy
(Eads)
functional
groups
(-NH2,
-COOH
-CN3H4),
acids
(arginine
(Arg),
glycine
(Gly),
aspartic
acid
(Asp)),
dipeptides
(arginine–glycine
(Arg-Gly),
glycine–aspartic
(Gly-Asp),
arginine–aspartic
(Arg-Asp)),
arginine–glycine–aspartic
(RGD)
tripeptide
systematically
calculated.
Dipole
correction
slightly
enhanced
between
surfaces,
but
Eads
trend
remained
unchanged.
addition
improved
Mg-based
surfaces.
This
will
be
fundamental
importance
understanding
surfaces
provide
possibilities
for
surface
modification
design
materials.
Polymers,
Год журнала:
2024,
Номер
16(2), С. 198 - 198
Опубликована: Янв. 9, 2024
Polylactic
acid
(PLA)
has
attracted
much
attention
in
bone
tissue
engineering
due
to
its
good
biocompatibility
and
processability,
but
it
still
faces
problems
such
as
a
slow
degradation
rate,
acidic
product,
weak
biomineralization
ability,
poor
cell
response,
which
limits
wider
application
developing
scaffolds.
In
this
study,
Mg(OH)2
nanoparticles
were
employed
versatile
nanofiller
for
PLA/Mg(OH)2
composite
scaffolds
using
fused
deposition
modeling
(FDM)
3D
printing
technology,
mechanical,
degradation,
biological
properties
evaluated.
The
mechanical
tests
revealed
that
5
wt%
addition
of
improved
the
tensile
compressive
strengths
PLA
scaffold
by
20.50%
63.97%,
respectively.
soaking
experiment
phosphate
buffered
solution
(PBS)
alkaline
products
neutralized
PLA,
thus
accelerating
PLA.
weight
loss
rate
PLA/20Mg(OH)2
(15.40%)
was
significantly
higher
than
(0.15%)
on
day
28.
Meanwhile,
showed
long-term
Mg2+
release
more
28
days.
simulated
body
fluid
(SBF)
immersion
indicated
promoted
apatite
culture
marrow
mesenchymal
stem
cells
(BMSCs)
adding
effectively
responses,
including
adhesion,
proliferation,
osteogenic
differentiation,
Mg2+.
This
study
suggests
can
simultaneously
address
various
issues
related
polymer
scaffolds,
properties,
interaction,
having
promising
applications
engineering.
The
rapid
degradation
of
magnesium
(Mg)
alloy
implants
erodes
mechanical
performance
and
interfacial
bioactivity,
thereby
limiting
their
clinical
utility.
Surface
modification
is
among
the
solutions
to
improve
corrosion
resistance
bioefficacy
Mg
alloys.
Novel
composite
coatings
that
incorporate
nanostructures
create
new
opportunities
for
expanded
use.
Particle
size
dominance
impermeability
may
increase
prolong
implant
service
time.
Nanoparticles
with
specific
biological
effects
be
released
into
peri-implant
microenvironment
during
promote
healing.
Composite
nanocoatings
provide
nanoscale
surfaces
cell
adhesion
proliferation.
activate
cellular
signaling
pathways,
while
those
porous
or
core-shell
structures
carry
antibacterial
immunomodulatory
drugs.
vascular
reendothelialization
osteogenesis,
attenuate
inflammation,
inhibit
bacterial
growth,
thus
increasing
applicability
in
complex
microenvironments
such
as
atherosclerosis
open
fractures.
This
review
combines
physicochemical
properties
efficiency
Mg-based
biomedical
summarize
advantages
nanocoatings,
analyzes
mechanisms
action,
proposes
design
construction
strategies,
purpose
providing
a
reference
promoting
application
further
nanocoatings.
Smart Materials in Manufacturing,
Год журнала:
2023,
Номер
1, С. 100022 - 100022
Опубликована: Янв. 1, 2023
With
promising
mechanical
property
and
biodegradability,
magnesium
(Mg)
alloys
are
considered
as
the
potential
candidates
in
biomedical
application.
Rapid
degradation
of
Mg
compromises
performance
interfacial
bioactivity,
hindering
clinical
adoption.
Deposition
a
surface
coating
is
an
effective
technique
to
improve
corrosion
protection
bio-efficacy
implants.
Because
natural
degradability
corrosion,
inevitably
damaged
complex
physiological
environment.
Therefore,
it
essential
form
self-healing
that
can
repair
damage
restore
stable
structure
functions
alloys.
This
paper
reviews
recent
advances
technology
related
properties
including
biodegradation
behavior,
self-repairing
activity,
biocompatibility,
other
biological
effects,
healing
mechanism
discussed.
Self-healing
coatings
suitable
for
include
conversion
coatings,
encapsulation
multilayered
their
vitro
vivo
reviewed
by
focusing
on
drug-controlled
prolonged
release,
sterilization,
cytocompatibility,
osteogenesis,
hemocompatibility,
angiogenesis.
review
aims
at
providing
guidance
future
research
development
practical
Advances in chemical and materials engineering book series,
Год журнала:
2024,
Номер
unknown, С. 206 - 230
Опубликована: Фев. 27, 2024
Nanotechnology
has
emerged
as
a
revolutionary
field
with
diverse
applications,
including
nanocoatings
for
medicinal
purposes.
Nanocoatings,
their
unique
properties
and
capabilities,
have
opened
new
avenues
drug
delivery,
medical
devices,
antimicrobial
treatments.
Nanocoatings
can
be
engineered
to
encapsulate
therapeutic
agents,
protecting
them
from
degradation
facilitating
targeted
delivery
specific
tissues
or
cells.
The
use
of
on
surfaces
also
shown
promising
results
in
preventing
infections
combating
antibiotic-resistant
pathogens.
While
offer
tremendous
potential,
concerns
about
potential
toxicity,
biocompatibility,
long-term
effects
require
rigorous
evaluation
testing.
Furthermore,
the
study
highlights
ongoing
research
future
prospects
nanocoatings.
development
multifunctional
that
combine
sensing
tissue
regeneration
holds
promise
personalized
medicine
advanced
therapeutics.
Results in Surfaces and Interfaces,
Год журнала:
2024,
Номер
15, С. 100227 - 100227
Опубликована: Май 1, 2024
Osteoconductive,
biocompatible,
and
biodegradable
magnesium
alloys
hold
great
promise
as
novel
materials
for
orthopaedic
vascular
implants
due
to
their
bone-like
mechanical
properties.
Furthermore,
limited
utility
in
therapeutic
environments
is
compounded
by
inadequate
resistance
corrosion.
Because
the
impulsive
occurrence
of
corrosion
governed
loss
properties,
including
materials'
fundamental
properties
various
corrosive
conditions,
mechanism
extremely
complex.
Due
incidence
numerous
factors,
inherent
presence
environments,
complexity-ridden.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(39), С. 9863 - 9893
Опубликована: Янв. 1, 2024
Schematic
diagram
of
the
device,
mechanism
and
biomedical
application
electrodeposition
for
preparation
bioactive
coatings
on
surface
titanium
implants
bone
repair.
