Ceramics International, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Advanced Science, Год журнала: 2023, Номер 10(29)
Опубликована: Сен. 13, 2023
Abstract Owing to their mechanical resilience and non‐toxicity, titanium implants are widely applied as the major treatment modality for clinical intervention against bone fractures. However, intrinsic bioinertness of Ti its alloys often impedes effective osseointegration implants, leading severe adverse complications including implant loosening, detachment, secondary damage. Consequently, new engineering strategies urgently needed improve after implantation. Remarkably, metalorganic frameworks (MOFs) a class novel synthetic material consisting coordinated metal species organic ligands, which have demonstrated plethora favorable properties modulating interfacial implants. This review comprehensively summarizes recent progress in development MOF‐coated highlights potential utility bio‐implant interface osseointegration, discussions outlined according physical traits, chemical composition, drug delivery capacity. A perspective is also provided this regarding current limitations future opportunities orthopedic applications. The insights may facilitate rational design more advanced with enhanced therapeutic performance safety.
Язык: Английский
Процитировано
24
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 2, 2025
Abstract Metal implants are commonly used in clinical practice. However, little is known regarding the prevalence of metal implants. Therefore, this study aimed to evaluate United States (US) among individuals aged ≥ 40 years. This conducted a serial cross-sectional analysis US adults years who participated National Health and Nutrition Examination Survey (NHANES) (2015–2016 2017–March 2020). Self-reported questionnaires were assess whether participants had inside their bodies. The primary outcome was older. Furthermore, weighted logistic regression employed determine changes from 2015 March 2020. Moreover, investigated variation implant by demographic factors based on pooled NHANES cycles. All analyses 3,736 2015–2016 6,387 observed high older (2015–2016: 27.23%; 2020: 31.53%). results showed that significantly increased 2020, especially individuals, men, White individuals. In addition, indicated differed age race/ethnicity, which higher than younger non-White respectively. There older, more attention needs be paid special population, it may necessary ensure accessibility affordability potential long-term health impacts implants, considering
Язык: Английский
Процитировано
1
Biomacromolecules, Год журнала: 2025, Номер unknown
Опубликована: Янв. 11, 2025
Emerging techniques of additive manufacturing, such as vat-based three-dimensional (3D) bioprinting, offer novel routes to prepare personalized scaffolds complex geometries. However, there is a need develop bioinks suitable for clinical translation. This study explored the potential bacterial-sourced methacrylate levan (LeMA) bioink digital light processing (DLP) 3D bioprinting bone tissue scaffolds. LeMA was successfully synthesized, characterized, and used fabricate 3D-bioprinted with excellent printability physicochemical properties. In vitro studies demonstrated superior cytocompatibility 15% w/v gels compared 20% gels. supported osteogenic differentiation , evidenced by alkaline phosphatase activity mineral deposition MC3T3 pre-osteoblasts. Importantly, hydrogels positively modulated macrophage phenotype, promoting expression anti-inflammatory marker CD206. These findings suggest that 3D-printed can create favorable microenvironment regeneration, highlighting their repair regeneration applications.
Язык: Английский
Процитировано
1
Acta Biomaterialia, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101531 - 101531
Опубликована: Фев. 5, 2025
Three-dimensional (3D) printing technology has shown significant promise in the medical field, particularly orthopedics, prosthetics, tissue engineering, and pharmaceutical preparations. This review focuses on innovative application of 3D addressing challenges osteonecrosis femoral head (ONFH). Unlike traditional hip replacement surgery, which is often suboptimal for younger patients, offers precise localization necrotic areas ability to create personalized implants. By integrating advanced biomaterials, this a promising strategy approach early hip-preserving treatments. Additionally, 3D-printed bone engineering scaffolds can mimic natural environment, promoting regeneration vascularization. In future, potential extends combining with artificial intelligence optimizing treatment plans, developing materials enhanced bioactivity compatibility, translating these innovations from laboratory clinical practice. demonstrates how uniquely addresses critical ONFH treatment, including insufficient vascularization, poor mechanical stability, limited long-term success conventional therapies. introducing gradient porous scaffolds, bioactive material coatings, AI-assisted design, work outlines novel strategies improve interventions. These advancements not only enhance efficacy but also pave way findings into applications.
Язык: Английский
Процитировано
1
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(39), С. 9863 - 9893
Опубликована: Янв. 1, 2024
Schematic diagram of the device, mechanism and biomedical application electrodeposition for preparation bioactive coatings on surface titanium implants bone repair.
Язык: Английский
Процитировано
7
Regenerative Biomaterials, Год журнала: 2024, Номер 11
Опубликована: Янв. 1, 2024
Abstract The intricate nature of oral-maxillofacial structure and function, coupled with the dynamic oral bacterial environment, presents formidable obstacles in addressing repair regeneration bone defects. Numerous characteristics should be noticed repair, such as irregular morphology defects, homeostasis between hosts microorganisms cavity complex periodontal structures that facilitate epithelial ingrowth. Therefore, necessitates restoration materials adhere to stringent specific demands. This review starts exploring these particular requirements by introducing bones then summarizes classifications current respect composition structure. Additionally, we discuss modifications including improving mechanical properties, optimizing surface topography pore adding bioactive components elements, compounds, cells their derivatives. Ultimately, organize a range potential optimization strategies future perspectives for enhancing materials, physical environment manipulation, microbial modulation, osteo-immune regulation, smart stimuli-responsive multifaceted approach poly-pathic treatment, hope providing some insights researchers this field. In summary, analyzes demands especially alveolar bone, concludes corresponding biomaterials aims inspire research pursuit more effective treatment outcomes.
Язык: Английский
Процитировано
6
Materials Today Bio, Год журнала: 2023, Номер 23, С. 100866 - 100866
Опубликована: Ноя. 26, 2023
The significance of the osteogenesis-angiogenesis relationship in healing process bone defects has been increasingly emphasized recent academic research. Surface topography plays a crucial role guiding cellular behaviors. Metal-organic framework (MOF) is an innovative biomaterial with nanoscale structural and topological features, enabling modulation scaffold physicochemical properties. This study involved loading varying quantities UiO-66 nanocrystals onto alkali-heat treated 3D-printed titanium scaffolds, resulting formation hierarchical micro/nano named UiO-66/AHTs. properties these scaffolds were subsequently characterized. Furthermore, impact on osteogenic potential BMSCs, angiogenic HUVECs, their intercellular communication investigated. findings this indicated that 1/2UiO-66/AHT outperformed other groups terms induction, as well promoting crosstalk by enhancing paracrine effects. These results suggest promising biomimetic design facilitates coupling osteogenesis angiogenesis.
Язык: Английский
Процитировано
13
Bioactive Materials, Год журнала: 2024, Номер 43, С. 48 - 66
Опубликована: Сен. 17, 2024
Язык: Английский
Процитировано
5
Journal of Advanced Research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0