Application of Advanced Surface Modification Techniques in Titanium-Based Implants: Latest Strategies for Enhanced Antibacterial Properties and Osseointegration

Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Titanium-based implants, renowned for their excellent mechanical properties, corrosion resistance, and biocompatibility, have found widespread application as premier implant materials in the medical field. However, bioinert materials, they often face challenges such failure caused by bacterial infections inadequate osseointegration post-implantation. Thus, to address these issues, researchers developed various surface modification techniques enhance properties bioactivity of titanium-based implants. This review aims outline several key methods including acid etching, sol-gel method, chemical vapor deposition, electrochemical techniques, layer-by-layer self-assembly, grafting. It briefly summarizes advantages, limitations, potential applications technologies, presenting readers with a comprehensive perspective on latest advances trends

Язык: Английский

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Reinforcing titanium surface modification through the integration of piezoelectric effect and structural design to mitigate early bacterial infection

Ceramics International, Год журнала: 2024, Номер 50(21), С. 42645 - 42655

Опубликована: Авг. 6, 2024

Язык: Английский

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NSUN2 methylates IRF4 to affect the capacity of macrophages attached to titanium implant on osteogenic differentiation of PDLSCs and angiogenesis of HUVECs in vitro

BMC Oral Health, Год журнала: 2024, Номер 24(1)

Опубликована: Ноя. 13, 2024

We aimed to investigate the effect and underlying mechanism of titanium (Ti) implant on polarization macrophages subsequent effects osteogenic differentiation periodontal ligament stem cells (PDLSCs) angiogenesis human umbilical vein endothelial (HUVECs) affected by macrophages. Firstly, regulatory Ti macrophage was investigated. Levels M1 markers M2 in were evaluated immunofluorescence staining method qPCR analysis. The capacity PDLSCs cultured with supernatants each group Alizarin Red S (ARS) qPCR. Angiogenesis related genes also HUVECs To explore whether RNA m5C modification can modulate regulation angiogenesis, we analyzed main using dot blotting methods. interaction between NSUN2 IRF4 verified m5C-RIP, RIP, double-luciferase gene report experiments. Macrophages activated as under interference LPS, attached implants more easily action LPS. enhanced HUVECs. level up-regulated treated LPS down-regulated implant. Over-expression attenuated promotion Up-regulation weakened KEGG analysis suggested that enriched several inflammatory signaling pathways. Moreover, methylates affect Taken together, type be stimulated vitro, promoting through NSUN2-mediated methylation IRF4.

Язык: Английский

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Effects of La/Mn-Ceria&TiO2 Heterojunction on Titanium Implants: Improved Regenerative Repair of Diabetic Bone with Enhanced Antioxidant Characteristics

Ceramics International, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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