International Journal of Biological Macromolecules, Год журнала: 2024, Номер 285, С. 138349 - 138349
Опубликована: Дек. 4, 2024
Язык: Английский
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Abstract Hyperglycemia and its induced oxidative stress microenvironment present formidable challenges to the repair of diabetic bone defects. Herein, a novel TZGP (α‐TCP/ZnO/GM@P2) composite scaffold for defect is developed. Characterization results demonstrate that α‐TCP cement scaffold, ZnO nanoparticles, gelatin microspheres loaded with protecting P2 (a parathyroid hormone‐related peptide) achieve complementary advantages. The while meeting mechanical strength requirements cancellous bone, compensates deficiency bioactive peptides in inorganic scaffolds. Its biocompatibility enhanced, endowed antibacterial antioxidant properties. vitro vivo reveal releases active factors Zn 2+ , promotes cell proliferation recruitment high‐glucose microenvironment, reduces cellular reactive oxygen species accumulation, improves DNA injury mitochondrial homeostasis, induces osteogenic‐angiogenic differentiation. Compared conventional exhibits more excellent biodegradability, accelerates local tissue filling, accumulation vascular reconstruction Consequently, design strategy offers promising approach repairing
Язык: Английский
Процитировано
2
Advanced Science, Год журнала: 2024, Номер 11(14)
Опубликована: Фев. 2, 2024
Abstract Chronic diabetic wounds are a serious complication of diabetes and often result in limb amputations confer high mortality rates. The proinflammatory secretome the wound perpetuates defective neovascularization contributes to dysregulated tissue repair. This study aims design gelatin methacrylamide (GelMA) hydrogel sustained release grancalcin‐neutralizing antibody (GCA‐NAb) evaluate it as potential scaffold promote healing. Results show that expression grancalcin(GCA), protein secreted by bone marrow‐derived immune cells, is elevated sites individuals animals with ulcers. Genetic inhibition grancalcin accelerates vascularization healing an animal model. Mechanistic studies binds transient receptor melastatin 8(TRPM8) partially inactivates its downstream signaling pathways, thereby impairing angiogenesis vitro ex vivo. Systemic or topical administration GCA‐NAb accelerate repair mice diabetes. data suggest GCA therapeutic target for treatment
Язык: Английский
Процитировано
10
Nano Letters, Год журнала: 2024, Номер 24(31), С. 9494 - 9504
Опубликована: Июль 26, 2024
Chronic diabetic wound patients usually show high glucose levels and systemic immune disorder, resulting in reactive oxygen species (ROS) cell dysfunction, prolonged inflammation, delayed healing. Herein, we prepared an antioxidant immunomodulatory polymer vesicle for treatment. This is self-assembled from poly(ε-caprolactone)36-block-poly[lysine4-stat-(lysine-mannose)22-stat-tyrosine)16] ([PCL36-b-P[Lys4-stat-(Lys-Man)22-stat-Tyr16]). Polytyrosine polypeptide that can scavenge ROS. d-Mannose was introduced to afford functions by promoting macrophage transformation Treg activation through inhibitory cytokines. The mice treated with vesicles showed 23.7% higher a 91.3% M2/M1 ratio than those PBS. Animal tests confirmed this accelerated healing achieved complete of S. aureus-infected wounds within 8 days. Overall, the first scavenging ROS regulating homeostasis, opening new avenues effective
Язык: Английский
Процитировано
9
Опубликована: Янв. 13, 2025
Aim: To expand the understanding of structure-activity relationship within a family amino acid-derived β-lactam TRPM8 (transient receptor potential melastatin channel, subtype 8) antagonists, this work investigated both configuration-dependence potency and selectivity, explored strategies for increasing total polar surface area (TPSA). Methods: Diastereoisomeric compounds derived from H-Phe-OtBu, analogues incorporating differently substituted benzoyl groups, were synthesized by stereoselective solution pathways. Ca2+ microfluorometry assays used antagonist activity assessment, then confirmed through electrophysiology (patch-clamp assay). The pharmacological in vivo was studied on mice model oxaliplatin-induced peripheral neuropathy. Results: For OtBu derivatives, 3S,4S-configuration preferred, while with 2'R chiral centers show higher selectivity versus transient vanilloid, 1 (TRPV1) than their 2'S-counterparts. N-terminal which increased TPSA values, resulted equipotent as previous prototypes, but also showed other pain-related targets [TRPV1 cannabinoid receptor, 2 (CB2R)]. A selected N-benzoyl derivative displays antinociceptive vivo. Conclusions: these antagonists developed acid derivatives depend not only configuration substituents at 4-carboxy groups. Dual multitarget discovered antagonists.
Язык: Английский
Процитировано
1
Biomedical Technology, Год журнала: 2025, Номер 9, С. 100071 - 100071
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
0
MedComm, Год журнала: 2025, Номер 6(4)
Опубликована: Март 22, 2025
Abstract Wound healing remains a critical global healthcare challenge, with an annual treatment cost exceeding $50 billion worldwide. Over the past decade, significant advances in wound care have focused on developing sophisticated biomaterials that promote tissue regeneration and prevent complications. Despite these developments, there crucial need for multifunctional materials can effectively address complex, multiphase nature of repair while being effective easily applicable various clinical settings. This review systematically analyzes latest developments materials, examining their chemical composition, structural design, therapeutic mechanisms. We comprehensively evaluate bioactive components, including natural polymers, synthetic matrices, hybrid composites, along different forms, such as hydrogels, powders, smart dressings. Special attention is given to emerging strategies material design integrate multiple functions, sustained drug delivery, infection prevention, promotion. The insights provided this illuminate path toward next‐generation highlighting opportunities more solutions significantly improve patient outcomes reduce burden.
Язык: Английский
Процитировано
0
Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119727 - 119727
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Carbohydrate Polymers, Год журнала: 2024, Номер 348, С. 122780 - 122780
Опубликована: Сен. 24, 2024
Язык: Английский
Процитировано
2
Acta Biomaterialia, Год журнала: 2024, Номер 190, С. 95 - 106
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 285, С. 138349 - 138349
Опубликована: Дек. 4, 2024
Язык: Английский
Процитировано
0