Photochemistry and Photobiology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 9, 2024
Photodynamic therapy (PDT) effectively kills cancer cells and initiates immune responses that promote anticancer effects locally systemically. Primarily developed for local regional cancers, the potential of PDT systemic antitumor [in situ photo-vaccination (ISPV)] remains underexplored. This study investigates: (1) comparative effectiveness paclitaxel (PTX) prodrug [Pc-(L-PTX)
Язык: Английский
Advanced Science, Год журнала: 2024, Номер 11(12)
Опубликована: Янв. 17, 2024
Abstract For tumor treatment, the ultimate goal in therapy is to eliminate primary tumor, manage potential metastases, and trigger an antitumor immune response, resulting complete clearance of all malignant cells. Tumor microenvironment (TME) refers local biological environment solid tumors has increasingly become attractive target for cancer therapy. Neutrophils within TME gastric (GC) spontaneously undergo ferroptosis, this process releases oxidized lipids that limit T cell activity. Enhanced photodynamic (PDT) mediated by di‐iodinated IR780 (Icy7) significantly increases production reactive oxygen species (ROS). Meanwhile, neutrophil ferroptosis can be triggered increased ROS generation TME. In study, a liposome encapsulating both inhibitor Liproxstatin‐1 modified photosensitizer Icy7, denoted LLI, inhibits growth GC. LLI internalizes into MFC cells generate causing immunogenic death (ICD). Simultaneously, liposome‐deliver effectively neutrophils. LLI‐based PDT neutrophil‐targeting immunotherapy synergistically boost anti‐PD‐1 treatment elicit potent systemic response with abscopal effects. conclusion, holds great GC immunotherapy.
Язык: Английский
Процитировано
20
ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Despite significant clinical breakthroughs in anti-tumor immunotherapy, its therapy efficiency remains hindered by insufficient "cold" tumor immune responses. The ample reactive oxygen species photodynamic (PDT) can trigger the immunogenic cell death (ICD) pathway for arousing system and realizing immunotherapy. But inherent hypoxic microenvironment (TME) limits PDT efficacy. To simultaneously reverse TME promote ICD pathway, multi-in-one nanostructure (FAIC) is designed, which catalase (CAT) photosensitizer (I-Cy5) are encapsulated a folate receptor-targeting liposome. Due to endoplasmic reticulum (ER)-targeting ability of I-Cy5, H2O2 decomposition catalytic CAT, cell-targeting liposome, severe ER stress triggered nano FAIC pathway. As result, infiltration cytotoxic T lymphocytes promoted, response boosted. design corresponding mechanism provide potential way realize efficient
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
Abstract In situ tumor vaccines, which utilize antigens generated during treatment to stimulate a cancer patient's immune system, has become potential field in immunotherapy. However, due the immunosuppressive microenvironment (ITME), generation of is always mild and not sufficient. Tumor‐resident intracellular bacteria have been identified as complete component contribute creating ITME. Herein, tumor‐resident scavenger designed induce enhanced antitumor photoimmunotherapy‐driven vaccines for treating hypoxic tumors. This developed by integrating photosensitizer CyI antibiotics Doxycycline (Doxy) into thermal‐sensitive tumor‐derived exosomes fused liposomes (ECDL). vitro vivo results showed that ECDL could homologous target cells restrict respiration mitochondrial reduce hypoxia, thus providing continuous oxygen eliminate both bacteria, ablating primary inhibiting metastasis recurrence. Moreover, eliminating neutralizes ITME triggers production bacterial‐related neoantigens, further strength study provided versatile effective are promising local, abscopal, metastatic treatment.
Язык: Английский
Процитировано
0
ACS Photonics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Photodynamic therapy and photothermal have emerged as indispensable modalities to treat diseases. However, their efficacy is hindered by the substantial light scattering within tissues, preventing transmission effectively targeted lesion sites. Various existing devices aimed at mitigating typically exhibit invasiveness complexity. In this work, we propose an approach that utilizes a portable acoustic holographic optical waveguide device mitigate manipulating refractive index tissues. This manipulation allows in situ modulation of scattered light, thereby promoting concentration photon energy. We demonstrated can medium through simulation imaging experiments. Second, both photodynamic experiments enhance rate temperature rise singlet oxygen (1O2) generation, respectively. It foreseeable versatility overcoming augment outcomes phototherapy, offering noninvasive, portable, robust method.
Язык: Английский
Процитировано
0
Smart Materials in Medicine, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Antioxidants, Год журнала: 2025, Номер 14(3), С. 258 - 258
Опубликована: Фев. 24, 2025
Oxidative stress, which is characterized by an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, has critical roles in the initiation, progression, treatment of gastric cancer. On one hand, excessive ROS accumulation induces oxidative damage cancer cell death. other moderate levels cause genetic mutations dysregulation signaling pathways to promote proliferation, inflammation, angiogenesis, metastasis Notably, emerging evidence revealed that also mediate post-translational modifications (oxPTMs) redox-sensitive proteins, can directly affect protein functions regulate redox cells. Therefore, elucidating regulatory mechanisms stress holds great promise identify novel therapeutic targets or redox-targeting strategies. This review will summarize regulating hallmarks highlight ROS-mediated oxPTMs In addition, we discuss strategies targeting for cancer, with emphasis on use bioactive natural products nanomaterials.
Язык: Английский
Процитировано
0
Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13
Опубликована: Март 21, 2025
The early diagnosis rate of gastric cancer is low, and most patients are already at an advanced stage by the time they diagnosed, posing significant challenges for treatment exhibiting high recurrence rates, which notably diminish patients’ survival quality life. Therefore, there urgent need to identify methods that can enhance efficacy. Nanomedicine, distinguished its small size, targeting specificity, strong biological compatibility, particularly well-suited address toxic side effects associated with current diagnostic therapeutic approaches cancer. Consequently, application nanomedicine delivery systems in has garnered increasing interest from researchers. This review provides overview recent advancements use nanomaterials as drugs or drug research, encompassing their applications diagnosis, chemotherapy, radiotherapy, surgery, phototherapy, explores promising prospects
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
Abstract Small cell lung cancer (SCLC) is an extremely aggressive and highly malignant type of that frequently develops resistance recurrence following initial treatment. Paclitaxel (PTX) a second‐line therapeutic option for SCLC patients with to first‐line However, its clinical application limited due suboptimal efficacy the risk hypersensitivity reactions. To address these challenges, novel strategy employing cationic liposome‐based biomimetic drug co‐delivery system, siPFKFB4/PRL PTX @RBCM‐cRGD, which simultaneously delivers paclitaxel PFKFB4‐targeting small interfering RNA (siRNA) cells tissues proposed. These findings demonstrate this system can induce ferroptosis in cells, thereby enhancing their sensitivity paclitaxel. Moreover, It promotes infiltration immune secretion cytokines within microenvironment, effectively activating anti‐tumor immunity. When combined anti‐PD‐L1 antibodies, it further potentiates responses. results suggest codelivery not only induces enhance but also reprograms potentiating effects immunotherapy providing promising new SCLC.
Язык: Английский
Процитировано
0
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 12, 2025
The PEGylation of drug-carrying nanoparticles has often been used to prolong blood circulation and improve drug deposition at tumor sites. Nevertheless, the PEG-rich hydrophilic surfaces retard release payloads internalization therapeutic by cancer cells, thus lowering anticancer efficacy. To boost potency combined photodynamic therapy (PDT) photothermal (PTT) against melanoma conquering PEG dilemma, herein, hybrid PEGylated chitosan-covered polydopamine (PDA) (PCPNs) with acidity-elicited detachment ability were fabricated as carriers IR780, a small-molecule photosensitizer for PTT PDT. IR780@PCPNs displayed uniform, solid-like spherical shape sound colloidal stability. Under near-infrared (NIR) irradiation, showed prominent conversion efficiency (ca. 54.6%), robust stability, reduced IR780 photobleaching, sufficient singlet oxygen (1O2) production, glutathione-depleting ability. Moreover, environmental pH being from 7.4 5.0 37 °C, decreased interactions between PCPNs due increased protonation phenolic hydroxyl residues within PDA primary amine groups chitosan accelerated species IR780@PCPNs. Importantly, cellular uptake B16F10 was remarkably promoted in weakly acidic milieu upon driven disintegration acid-labile benzoic imine. With NIR internalized generated hyperthermia 1O2 damage mitochondria, thereby effectively inhibiting proliferation cells. Collectively, our findings present practical strategy amplifying efficacy PDT using PEG-detachable
Язык: Английский
Процитировано
0
Biomedicines, Год журнала: 2025, Номер 13(4), С. 950 - 950
Опубликована: Апрель 12, 2025
Immunogenic cell death (ICD) is a promising cancer therapy where dying tumor cells release damage-associated molecular patterns (DAMPs) to activate immune responses. Recent research highlights the critical role of metabolic reprogramming in cells, including Warburg effect, oxidative stress, and lipid metabolism, modulating ICD shaping microenvironment. These changes enhance activation, making tumors more susceptible surveillance. This review explores mechanisms linking mitochondrial endoplasmic reticulum (ER) ferroptosis. It also discusses innovative therapeutic strategies, such as personalized combination therapies, inhibitors, targeted delivery systems, improve efficacy. The future immunotherapy lies integrating activation overcome evasion, with multi-omics approaches microbiome modulation offering new avenues for enhanced treatment outcomes.
Язык: Английский
Процитировано
0