Abstract
Magnetic
microparticles
(MPs)
and
nanoparticles
(NPs)
have
long
been
used
as
ideal
miniaturized
delivery
detection
platforms.
Their
use
micro‐
nanorobots
(MNRs)
is
also
emerging
in
the
recent
years
with
help
of
more
dedicated
external
magnetic
field
manipulations.
In
this
review,
we
summarize
research
progress
on
nanoparticle
(MNP)‐based
MNRs.
First,
fabrication
from
either
template‐assisted
NP
doping
methods
or
directly
synthesized
MPs
summarized.
The
driving
torque
sources
for
both
types
MNRs
are
analyzed,
their
propulsion
control
under
low
Reynolds
number
flows
discussed
by
evaluating
symmetry
breaking
mechanisms
interparticle
interactions.
Subsequently,
these
scientific
models,
bioimaging
agents,
active
delivery,
treatment
platforms
(drug
cell
sterilization),
biomedical
diagnostics
has
reviewed.
Finally,
perspective
MNPs‐based
was
outlined,
including
challenges
future
directions.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(37), С. 9144 - 9154
Опубликована: Янв. 1, 2024
Cardiovascular
disease
(CVD)
is
a
global
health
concern,
presenting
significant
risks
to
human
health.
Atherosclerosis
among
the
most
prevalent
CVD,
impacting
medium
and
large
arteries
in
kidneys,
brain,
heart,
other
vital
organs,
as
well
lower
limbs.
As
progresses,
arterial
obstruction
can
result
heart
attacks
strokes.
Therefore,
patients
with
atherosclerosis
should
receive
accurate
diagnosis
timely
therapeutic
intervention.
With
advancements
nanomedicine,
researchers
have
proposed
new
research
strategies
methods
for
imaging.
This
paper
summarizes
some
current
findings
on
use
of
nanomaterials
diagnosing
offers
insights
optimizing
imaging
applications
future.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 11397 - 11413
Опубликована: Ноя. 1, 2024
Biocompatible
nanocarriers
are
widely
employed
as
drug-delivery
vehicles
for
treatment.
Nevertheless,
indiscriminate
drug
release,
insufficient
organ-specific
targeting,
and
systemic
toxicity
hamper
nanocarrier
effectiveness.
Stimuli-responsive
nano-sized
delivery
systems
(DDS)
an
important
strategy
enhancing
efficiency
reducing
unexpected
release.
Abstract
Nanoparticles
can
enhance
drugs
accumulating
at
the
tumor
site
and
hold
tremendous
promise
for
achieving
effective
treatment.
However,
due
to
complexity
of
cancer
heterogeneity
suppressive
microenvironment,
delivery
traditional
nanoparticles
has
poor
infiltration
off‐target
effects,
making
it
difficult
control
drug
release
rate
causing
toxicity.
In
recent
years,
cell
membrane‐coated
biomimetic
have
been
developed,
which
both
natural
characteristics
biomembranes
physical
nanoparticles,
thus
improving
homologous
targeting
ability
cells
better
biocompatibility.
this
paper,
we
reviewed
application
single
membrane
hybrid
in
integration
diagnosis
We
talked
about
preparation
methods
mechanisms,
effects
imaging
therapeutic
outcomes
different
detail.
Finally,
discussed
existing
problems
prospects
nanomaterials.
ACS Omega,
Год журнала:
2024,
Номер
9(49), С. 48642 - 48649
Опубликована: Ноя. 25, 2024
Oxidative
stress
and
inflammation
are
key
pathological
features
of
atherosclerotic
plaques.
Numerous
nanomedicines
have
been
developed
to
alleviate
oxidative
reduce
within
However,
nonbioactive
carrier
materials
the
bioavailability
may
pose
potential
biological
toxicity.
In
this
study,
we
utilized
unique
amphiphilic
chemical
structure
lipoic
acid
(LA)
prepare
LA
nanoparticles
(LA
NPs)
via
a
self-assembly
method.
Leveraging
inherent
anti-inflammatory
antioxidant
properties
LA,
these
NPs
were
used
for
treatment
atherosclerosis.
an
inflammatory
macrophage
model,
exhibited
superior
activity
compared
free
LA.
Through
ultrasound
imaging
methods,
discovered
that
demonstrated
nice
antiatherosclerotic
effects
in
mice
model.
Immunofluorescence
analysis
further
indicated
associated
with
alleviation
plaques,
reduced
infiltration,
downregulation
cytokine
levels.
Therefore,
offer
promising
therapeutic
strategy
Abstract
Magnetic
microparticles
(MPs)
and
nanoparticles
(NPs)
have
long
been
used
as
ideal
miniaturized
delivery
detection
platforms.
Their
use
micro‐
nanorobots
(MNRs)
is
also
emerging
in
the
recent
years
with
help
of
more
dedicated
external
magnetic
field
manipulations.
In
this
review,
we
summarize
research
progress
on
nanoparticle
(MNP)‐based
MNRs.
First,
fabrication
from
either
template‐assisted
NP
doping
methods
or
directly
synthesized
MPs
summarized.
The
driving
torque
sources
for
both
types
MNRs
are
analyzed,
their
propulsion
control
under
low
Reynolds
number
flows
discussed
by
evaluating
symmetry
breaking
mechanisms
interparticle
interactions.
Subsequently,
these
scientific
models,
bioimaging
agents,
active
delivery,
treatment
platforms
(drug
cell
sterilization),
biomedical
diagnostics
has
reviewed.
Finally,
perspective
MNPs‐based
was
outlined,
including
challenges
future
directions.
