Cuproptosis: Advances in Stimulus‐Responsive Nanomaterials for Cancer Therapy

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(19)

Опубликована: Апрель 15, 2024

Abstract Cuproptosis, a recently identified non‐apoptotic programmed cell death modality, attracts considerable attention in the realm of cancer therapeutics owing to its unique cellular demise mechanisms. Since initial report 2022, strategies inducing or amplifying cuproptosis for treatment emerge. The engineering nano‐systems elicit effectively circumvents constraints associated with conventional small‐molecule pharmaceutical interventions, presenting novel prospects oncological therapy. Stimulus‐responsive nanomaterials, leveraging their distinctive spatiotemporal control attributes, are investigated role modulating induction augmentation cuproptosis. In this comprehensive review, physiological characteristics cuproptosis, encompassing facets such as copper overload and depletion, coupled regulatory factors intrinsic expounded upon. Subsequently, design methodologies stimulus‐responsive enhancement employing stimuli light, ultrasound, X‐ray, tumor microenvironment, systematically delineated. This review encompasses intricacies nanomaterial design, insights into therapeutic processes, advantages. Finally, challenges inherent induction/enhancement deliberated upon prospective future trajectory copper‐mediated therapy provided.

Язык: Английский

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Treatment of Acute Wound Infections by Degradable Polymer Nanoparticle with a Synergistic Photothermal and Chemodynamic Strategy

Advanced Science, Год журнала: 2024, Номер 11(17)

Опубликована: Фев. 26, 2024

Mild-heat photothermal antibacterial therapy avoids heat-induced damage to normal tissues but causes bacterial tolerance. The use of in synergy with chemodynamic is expected address this issue. Herein, two pseudo-conjugated polymers P

Язык: Английский

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Custom‐Design of Multi‐Stimuli‐Responsive Degradable Silica Nanoparticles for Advanced Cancer‐Specific Chemotherapy

Small, Год журнала: 2024, Номер 20(35)

Опубликована: Апрель 23, 2024

Chemotherapy is crucial in oncology for combating malignant tumors but often encounters obatacles such as severe adverse effects, drug resistance, and biocompatibility issues. The advantages of degradable silica nanoparticles tumor diagnosis treatment lie their ability to target delivery, minimizing toxicity normal tissues while enhancing therapeutic efficacy. Moreover, responsiveness both endogenous exogenous stimuli opens up new possibilities integrating multiple modalities. This review scrutinizes the burgeoning utility combination with chemotherapy other Commencing elucidation synthesis degradation mechanisms, emphasis placed on these materials (e.g., pH, redox reactions, hypoxia, enzymes) light high-intensity focused ultrasound). this exploration delves into strategies harnessing alone, coupled radiotherapy, photothermal therapy, photodynamic gas immunotherapy, starvation chemodynamic elucidating multimodal synergies. Concluding an assessment advances, challenges, constraints oncology, despite hurdles, future investigations are anticipated augment role cancer therapy. These insights can serve a compass devising more efficacious combined strategies.

Язык: Английский

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Deciphering the Antibacterial Mechanism of Hollow Sphere Metal–Organic Frameworks against Staphylococcus aureus and Its Application in Wound Healing

Chemistry of Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Staphylococcus aureus infection and antimicrobial resistance (AMR) to antibiotics are two significant factors that pose escalating threats public health, potentially leading persistent pain or even death. Consequently, there is an urgent need for the development of alternative antibacterial materials. In this study, we have successfully developed a biocompatible nanosystem based on hollow spherical zeolitic imidazolate framework-67 (ZIF-67 HS), which exhibits remarkable bactericidal efficacy against Gram-positive S. both in vitro vivo. Importantly, our findings demonstrate prolonged exposure subminimum inhibitory concentrations ZIF-67 HS does not induce secondary as observed with conventional antibiotics; instead, it maintains sustained susceptibility toward antibiotic-resistant strains. Multiomics analyses (including transcriptomics, metabolomics, metalomics) indicated regulates 95 genes, 261 metabolites, 2 metal elements aureus. Through bioinformatics analysis combination bioassays, demonstrated disrupted multiple essential pathways pathogen, including amino acid metabolism, iron membrane transport, reactive oxygen species (ROS), pathways. Our suggest induces bacterial death through mechanisms rather than single target highlight its long-lasting properties. This study presents valuable insights into potential nanobiomedicine eradicating bacteria elucidates related molecular mechanism.

Язык: Английский

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Electron-reservoir applications of ferrocenes and other late transition-metal sandwich complexes: Flow batteries, sensing, catalysis, and biomedicine

Coordination Chemistry Reviews, Год журнала: 2024, Номер 524, С. 216300 - 216300

Опубликована: Ноя. 9, 2024

Язык: Английский

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A Novel Conjugated Polymer Synthesized via a Noble Metal-Free Catalyst in Photothermal Therapy of Hepatocellular Carcinoma Mediated by Second Near-Infrared (NIR-II) Laser

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101488 - 101488

Опубликована: Янв. 13, 2025

Photothermal therapy (PTT) utilizes photothermal materials to convert light energy into heat under external irradiation, effectively killing cancer cells. Therefore, the efficacy of PTT is largely determined by conversion efficiency material. In this study, we developed a novel ladder-type conjugated polymer, PPAPA, via phenazine ring fusion reaction. PPAPA exhibits high 75.2 % 1064 nm laser comparable benchmark organic agent SWCNT. Notably, synthesis avoids use noble metal catalysts, eliminating potential biotoxicity caused residual catalysts and ensuring optimal stability efficiency. Furthermore, demonstrates efficient near-infrared II (NIR-II) enabling deeper tissue penetration reduced absorption. This work comprehensively investigates properties evaluates its in tumor PTT, demonstrating as effective therapeutic strategy for treatment, offering new hope patients.

Язык: Английский

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Inhalable Polymeric Nanoparticle Containing Triphenylphosphanium Bromide‐modified Sonosensitizer for Enhanced Therapy of Acute Bacterial Pneumonia

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Abstract Sonodynamic therapy (SDT) has good feasibility to deeply seated infections, but SDT alone is insufficient being highly effective against multidrug‐resistant (MDR) bacteria. combined with triphenylphosphanium bromide (P + Ph 3 Br − ) expected solve this problem. This work develops a pseudo‐conjugated polymer P FCPS‐P containing cationic ‐modified sonosensitizer FCPS (FCPS‐P) and ROS‐sensitive thioketal bonds. assembled DSPE‐mPEG 2000 generate nanoparticle NP . effect generates ROS under ultrasound (US) stimulation. triggers the degradation of release FCPS‐P, endowing favored biosafety. targets bacterial surface through electrostatic interaction achieves killing synergistic action In vitro, +US gives >90% inhibition rates MDR ESKAPE pathogens, moreover, it causes metabolic disorders including inhibited nucleic acid synthesis, disordered energy metabolism, excessive oxidative stress, suppressed biofilm formation virulence. mice, exhibits 99.3% bactericidal rate in Pseudomonas aeruginosa ‐induced sublethal pneumonia renders 90% animal survival lethal pneumonia, additionally immunological staining transcriptomics analyses reveal that induces inflammatory response accelerated lung injury repair. Taken together, promising antibiotics‐alternative strategy for treating infections.

Язык: Английский

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“Thermal bubbles”: Photothermally triggered by a carbon monoxide nanocontainer for antibiosis and immune modulation therapy

Nano Today, Год журнала: 2025, Номер 63, С. 102758 - 102758

Опубликована: Апрель 14, 2025

Язык: Английский

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GSH-Triggered Nitric Oxide Release from Polyurethane Nanocarriers for Gas-Photothermal Synergistic Therapy of Bacterial-Infected Wounds

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Wound bacterial infections pose a significant challenge to global public health. Nitric oxide (NO), an endogenous gaseous molecule, shows great potential in antibacterial therapy. However, efficient NO delivery remains critical challenge. Photothermal therapy (PTT) offers noninvasive and highly localized treatment for infections. Leveraging the advantages of both approaches, this study developed polymer-based nanocarrier achieve synergistic PTT. For first time, amphiphilic polyurethane PEG-PNU-PEG containing dinitrate donors were synthesized, which further self-assembled into polymeric nanomicelles loaded with NIR emitting conjugated polymer. In microenvironment, elevated glutathione (GSH) triggered release. Simultaneously, polymer enabled effective photothermal therapy, promoting release gas Experimental results demonstrated that PTT effectively eradicated bacteria, eliminating 69.93% ± 2.79% S. aureus biofilm, > 4.5-fold improvement compared alone (14.8% 2.92%). The vitro assay showed inhibition rate exceeding 99.0%, while vivo studies on infected skin wounds revealed clearance 95.0% 1.95%. Furthermore, system suppressed inflammatory cytokines, promoted collagen deposition, accelerated regeneration, providing strategy broad-spectrum wound healing.

Язык: Английский

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Design, synthesis and biological evaluation of novel 4,6-dimorpholino-1,3,5-triazin-2-amine ferrocenecarboxylate derivatives as potent PI3K inhibitors

Bioorganic Chemistry, Год журнала: 2025, Номер 161, С. 108571 - 108571

Опубликована: Май 9, 2025

Язык: Английский

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