A tactfully designed photothermal agent collaborating with ascorbic acid for boosting maxillofacial wound healing DOI Creative Commons
Yuxin Qian, Yiting Gao, Dong Wang

и другие.

National Science Review, Год журнала: 2024, Номер 12(2)

Опубликована: Ноя. 26, 2024

ABSTRACT Maxillofacial injuries that may cause severe functional and aesthetic damage require effective immediate management due to continuous exposure diverse microbial populations. Moreover, drug resistance, biofilm formation, oxidative stress significantly impede timely bacterial removal immune function, making the exploration of advanced materials for maxillofacial wound healing an appealing yet highly challenging task. Herein, a near-infrared photothermal sterilization agent was designed, encapsulated with liposomes coated ascorbic acid known its antioxidant immune-regulatory functions. The resulting nanoparticles, 4TPE-C6T-TD@AA, effectively neutralize reactive oxygen species generated by lipopolysaccharides, facilitate conversion pro-inflammatory M1 macrophages anti-inflammatory M2 macrophages, eliminate >90% Staphylococcus aureus Escherichia coli disrupting physiological functions upon 808 nm laser irradiation. In vivo experiments demonstrate 4TPE-C6T-TD@AA rapidly eliminates bacteria from infected wounds in region rats, promotes S. aureus-infected enhancing collagen formation modulating inflammatory microenvironment. conclusion, this study presents promising therapeutic strategy combating infections excessive inflammation treating injuries.

Язык: Английский

Multifaceted Role of Nanocomposite Hydrogels in Diabetic Wound Healing: Enhanced Biomedical Applications and Detailed Molecular Mechanisms DOI

Gege Xiong,

Qiwei Chen, Qiuyu Wang

и другие.

Biomaterials Science, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Nanocomposite hydrogels offer a promising approach to treating diabetic wounds. Key findings include enhanced mechanical properties, antibacterial effects, and the ability regulate wound microenvironment.

Язык: Английский

Процитировано

0
A tactfully designed photothermal agent collaborating with ascorbic acid for boosting maxillofacial wound healing DOI Creative Commons
Yuxin Qian, Yiting Gao, Dong Wang

и другие.

National Science Review, Год журнала: 2024, Номер 12(2)

Опубликована: Ноя. 26, 2024

ABSTRACT Maxillofacial injuries that may cause severe functional and aesthetic damage require effective immediate management due to continuous exposure diverse microbial populations. Moreover, drug resistance, biofilm formation, oxidative stress significantly impede timely bacterial removal immune function, making the exploration of advanced materials for maxillofacial wound healing an appealing yet highly challenging task. Herein, a near-infrared photothermal sterilization agent was designed, encapsulated with liposomes coated ascorbic acid known its antioxidant immune-regulatory functions. The resulting nanoparticles, 4TPE-C6T-TD@AA, effectively neutralize reactive oxygen species generated by lipopolysaccharides, facilitate conversion pro-inflammatory M1 macrophages anti-inflammatory M2 macrophages, eliminate >90% Staphylococcus aureus Escherichia coli disrupting physiological functions upon 808 nm laser irradiation. In vivo experiments demonstrate 4TPE-C6T-TD@AA rapidly eliminates bacteria from infected wounds in region rats, promotes S. aureus-infected enhancing collagen formation modulating inflammatory microenvironment. conclusion, this study presents promising therapeutic strategy combating infections excessive inflammation treating injuries.

Язык: Английский

Процитировано

0