Regulation of T Cell Glycosylation by MXene/β‐TCP Nanocomposite for Enhanced Mandibular Bone Regeneration
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Immune-mediated
bone
regeneration
driven
by
biomaterials
offers
a
therapeutic
strategy
for
repairing
defects.
Among
2D
nanomaterials,
Ti3C2Tx
MXenes
have
garnered
substantial
attention
their
potential
in
tissue
regeneration.
This
investigation
concentrates
on
the
role
of
MXene
nanocomposites
modulating
immune
microenvironment
within
defects
to
facilitate
restoration.
are
synthetized,
incorporated
into
beta-tricalcium
phosphate
ceramics
(β-TCP)
(T-MXene),
and
osteoinductive
immunomodulatory
effects
evaluated.
The
T-MXene-treated
T-cells
marrow
stromal
cells
(BMSCs)
explored.
In
addition,
its
is
assessed
vivo
using
critical-sized
mandibular
defect
model.
underlying
mechanisms
which
T-MXene
regulates
T-cell
differentiation
explored
via
whole-transcriptome
RNA
sequencing.
scaffolds
activate
N-glycosylation
T
cells,
possess
anti-inflammatory
antioxidant
effects,
thereby
inducing
pro-regenerative
response.
increased
proportion
IL-4+
among
primary
lymph
nodes,
ultimately
promoting
osteogenesis
BMSCs
injured
mandibles.
distinctive
function
MXene-based
osteoimmunomodulation
provides
solid
foundation
further
exploration
application
as
response
modulators,
potentially
advancing
use
regenerative
medicine.
Язык: Английский
Engineered MXene Biomaterials for Regenerative Medicine
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 5, 2025
MXene-based
materials
have
attracted
significant
interest
due
to
their
distinct
physical
and
chemical
properties,
which
are
relevant
fields
such
as
energy
storage,
environmental
science,
biomedicine.
MXene
has
shown
potential
in
the
area
of
tissue
regenerative
medicine.
However,
research
on
its
applications
regeneration
is
still
early
stages,
with
a
notable
absence
comprehensive
reviews.
This
review
begins
detailed
description
intrinsic
properties
MXene,
followed
by
discussion
various
nanostructures
that
can
form,
spanning
from
0
3
dimensions.
The
focus
then
shifts
biomaterials
engineering,
particularly
immunomodulation,
wound
healing,
bone
regeneration,
nerve
regeneration.
MXene's
physicochemical
including
conductivity,
photothermal
characteristics,
antibacterial
facilitate
interactions
different
cell
types,
influencing
biological
processes.
These
highlight
modulating
cellular
functions
essential
for
Although
developing,
versatile
structural
attributes
suggest
role
advancing
Язык: Английский
Ti3C2Tx MXene‐Decorated 3D‐Printed Ceramic Scaffolds for Enhancing Osteogenesis by Spatiotemporally Orchestrating Inflammatory and Bone Repair Responses
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 8, 2024
Abstract
Inflammatory
responses
play
a
central
role
in
coordinating
biomaterial‐mediated
tissue
regeneration.
However,
precise
modulation
of
dynamic
variations
microenvironmental
inflammation
post‐implantation
remains
challenging.
In
this
study,
the
traditional
β‐tricalcium
phosphate‐based
scaffold
is
remodeled
via
ultrathin
MXene‐Ti
3
C
2
decoration
and
Zn
2+
/Sr
ion‐substitution,
endowing
with
excellent
reactive
oxygen
species‐scavenging
ability,
near‐infrared
responsivity,
enhanced
mechanical
properties.
The
induction
mild
hyperthermia
around
implant
periodic
irradiation
facilitates
spatiotemporal
regulation
inflammatory
cytokines
secreted
by
spectrum
macrophage
phenotypes.
process
initially
amplifies
pro‐inflammatory
response,
then
accelerates
M1‐to‐M2
polarization
transition,
yielding
satisfactory
pattern
osteo‐immunomodulation
during
natural
bone
healing
process.
Later,
sustained
release
ions
gradual
degradation
3D
maintains
favorable
reparative
M2‐dominated
immunological
microenvironment
that
supports
new
mineralization.
Precise
temporal
immunoregulation
intelligent
enhances
regeneration
rat
cranial
defect
model.
This
strategy
paves
way
for
application
materials
to
guide
toward
outcome,
making
clinical
treatment
more
predictable
durable.
findings
also
demonstrate
irradiation‐derived
promising
method
immunomodulation.
Язык: Английский
Application of Hydroxyapatite Composites in Bone Tissue Engineering: A Review
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(4), С. 127 - 127
Опубликована: Апрель 2, 2025
The
treatment
of
bone
defects
is
complicated
by
clinical
conditions,
such
as
trauma,
tumor
resection,
and
infection,
which
result
in
impair
the
bone’s
regenerative
capacity.
Hydroxyapatite
(HAp),
primary
inorganic
component
bone,
possesses
good
biocompatibility
osteoconductivity.
However,
it
has
poor
mechanical
properties,
a
slow
degradation
rate,
limited
functionality,
necessitating
combination
with
other
materials
to
broaden
its
application
scope.
This
paper
summarizes
importance
properties
HAp
composites
provides
categorized
review
current
research
on
tissue
engineering.
These
composite
scaffolds
not
only
offer
excellent
support
for
cell
growth
regeneration
but
also
facilitate
new
formation
vascularization.
Additionally,
challenges
faced
composites,
material
property
optimization
improvement
preparation
techniques,
are
discussed.
applications
defect
repair,
dental
implants,
spinal
fusion,
fields.
Язык: Английский
Dose-dependent enhancement of in vitro osteogenic activity on strontium-decorated polyetheretherketone
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 24, 2025
Polyetheretherketone
(PEEK)
is
widely
used
in
orthopedic
and
dental
implants
due
to
its
excellent
mechanical
properties,
chemical
stability,
biocompatibility.
However,
inherently
bioinert
nature
makes
it
present
weak
osteogenic
activity,
which
greatly
restricts
clinical
adoption.
Herein,
strontium
(Sr)
incorporated
onto
the
surface
of
PEEK
using
mussel-inspired
polydopamine
coating
improve
activity.
X-ray
photoelectron
spectroscopy
ion
release
assay
results
confirm
that
different
concentrations
Sr
are
substrate
surfaces.
The
strontium-modified
samples
show
a
stable
35
days
detection.
Better
MC3T3-E1
pre-osteoblasts
adhesion,
spreading,
proliferation
can
be
observed
groups,
demonstrates
with
improved
compatibility.
boosted
activity
has
been
demonstrated
by
better
performed
ALP
extracellular
matrix
mineralization,
collagen
secretion,
remarkable
up-regulation
ALP,
OCN,
OPN,
Runx2,
Col-I,
BSP,
OSX
pre-osteoblasts.
Additionally,
exhibit
dose-dependent
enhancement
osteoblasts
compatibility
PEEK-Sr10
group
shows
best.
These
findings
indicate
strontium-decorated
promising
application
implants.
Язык: Английский
Neuralized and vascularized fast bone regeneration using recombinant humanized type 1 collagen and native bone composite inorganic salts
APL Materials,
Год журнала:
2025,
Номер
13(3)
Опубликована: Март 1, 2025
Bone
injury
is
a
prevalent
condition
in
clinical
therapy
that
can
lead
to
significant
functional
impairments
and
substantially
disrupt
the
quality
of
life
for
patients.
However,
there
has
been
limited
breakthrough
achieving
neuralized
vascularized
rapid
bone
regeneration.
In
this
study,
we
collaborated
with
recombinant
humanized
collagen
1
(rhCOL1),
native
composite
inorganic
salts
(NBCISs),
methacrylated
silk
fibroin
(SilMA),
marrow
mesenchymal
stem
cells
(BMSCs)
construct
biomimetic
organic
bio-mineralized
multifunctional
organoids
repair
defects,
regeneration
within
just
six
weeks
rabbits.
We
first
determined
optimal
concentration
SilMA
(10%)
by
comprehensively
evaluating
crosslinking,
operability,
BMSC
proliferation.
The
rhCOL1
NBCIS
mixture
was
prepared
using
ratio
3:7,
reference
bone,
subsequently
added
create
biomineralized
microenvironments
NCSilMA.
Similarly,
proportions
were
optimized
based
on
their
effects
compressive
modulus,
swelling,
degradation.
As
result,
successfully
constructed
hydrogel
scaffold
defect
repair,
characterized
excellent
biodegradability,
appropriate
strength,
good
biocompatibility,
osteoinductive
biological
function.
Finally,
BMSC-loaded
NCSilMA
(organoids)
achieved
regeneration,
up-regulated
osteogenic
genes
enhanced
cell
colonization,
collagen,
polysaccharide
deposition.
Язык: Английский
Ultrasound-responsive Smart Biomaterials for Bone Tissue Engineering
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Bone
defects
resulting
from
trauma,
tumors,
or
other
injuries
significantly
impact
human
health
and
quality
of
life.
However,
current
treatments
for
bone
are
constrained
by
donor
shortages
immune
rejection.
tissue
engineering
has
partially
alleviated
the
limitations
traditional
repair
methods.
The
development
smart
biomaterials
that
can
respond
to
external
stimuli
modulate
biofunctions
become
a
prominent
area
research.
Ultrasound
technology
is
regarded
as
an
optimal
"remote
controller"
"trigger"
biomaterials.
This
review
reports
comprehensive
systematic
overview
ultrasound-responsive
It
presents
fundamental
theories
repair,
definition
ultrasound,
its
applications.
Furthermore,
summarizes
ultrasound
effect
mechanisms
their
roles
in
including
detailed
studies
on
anti-inflammation,
immunomodulation,
cell
therapy.
Finally,
advantages
future
prospects
this
field
discussed.
Язык: Английский