Strategies for promoting neurovascularization in bone regeneration

Military Medical Research, Год журнала: 2025, Номер 12(1)

Опубликована: Март 3, 2025

Abstract Bone tissue relies on the intricate interplay between blood vessels and nerve fibers, both are essential for many physiological pathological processes of skeletal system. Blood provide necessary oxygen nutrients to bone tissues, remove metabolic waste. Concomitantly, fibers precede during growth, promote vascularization, influence cells by secreting neurotransmitters stimulate osteogenesis. Despite critical roles components, current biomaterials generally focus enhancing intraosseous vessel repair, while often neglecting contribution nerves. Understanding distribution main functions in is crucial developing effective engineering. This review first explores anatomy highlighting their vital embryonic development, metabolism, repair. It covers innovative regeneration strategies directed at accelerating intrabony neurovascular system over past 10 years. The issues covered included material properties (stiffness, surface topography, pore structures, conductivity, piezoelectricity) acellular biological factors [neurotrophins, peptides, ribonucleic acids (RNAs), inorganic ions, exosomes]. Major challenges encountered neurovascularized materials clinical translation have also been highlighted. Furthermore, discusses future research directions potential developments aimed producing repair that more accurately mimic natural healing tissue. will serve as a valuable reference researchers clinicians novel into practice. By bridging gap experimental practical application, these advancements transform treatment defects significantly improve quality life patients with bone-related conditions.

Язык: Английский

Sensory Nerve Regulation via H3K27 Demethylation Revealed in Akermanite Composite Microspheres Repairing Maxillofacial Bone Defect

Advanced Science, Год журнала: 2024, Номер 11(30)

Опубликована: Июнь 14, 2024

Abstract Maxillofacial bone defects exhibit intricate anatomy and irregular morphology, presenting challenges for effective treatment. This study aimed to address these by developing an injectable bioactive composite microsphere, termed D‐P‐Ak (polydopamine‐PLGA‐akermanite), designed fit within the defect site while minimizing injury. The microspheres biodegraded gradually, releasing calcium, magnesium, silicon ions, which, notably, not only directly stimulated osteogenic differentiation of marrow mesenchymal stem cells (BMSCs) but also activated sensory nerve secrete calcitonin gene‐related peptide (CGRP), a key factor in repair. Moreover, released CGRP enhanced BMSCs through epigenetic methylation modification. Specifically, inhibition EZH2 enhancement KDM6A reduced trimethylation level histone 3 at lysine 27 (H3K27), thereby activating transcription genes such as Runx2 Osx. efficacy repair is validated rat mandibular model, demonstrating that peripheral response facilitates regeneration These findings illuminated novel strategy constructing neuroactive osteo‐inductive biomaterials with potential further clinical applications.

Язык: Английский

3D printed multi-elemental bioceramics induces favorable osteoimmunomodulation for osteogenesis

Ceramics International, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025