International Journal of Biological Macromolecules, Год журнала: 2024, Номер 289, С. 138620 - 138620
Опубликована: Дек. 13, 2024
Язык: Английский
Biomaterials, Год журнала: 2025, Номер unknown, С. 123129 - 123129
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Advanced Science, Год журнала: 2024, Номер 11(30)
Опубликована: Июнь 12, 2024
Senescent cancer cells are endowed with high immunogenic potential that has been leveraged to elicit antitumor immunity and potentially complement anticancer therapies. However, the efficacy of live senescent cell-based vaccination is limited by interference from immunosuppressive senescence-associated secretory phenotype pro-tumorigenic capacity cells. Here, a nanovaccine strong immunogenicity favorable for immunotherapy reported. The biomimetic integrating cell membrane-coated nanoadjuvant outperforms living in enhancing dendritic (DCs) internalization, improving lymph node targeting, immune responses. In contrast nanovaccines generated death-induced tumor cells, facilitate DC maturation, eliciting superior protection therapeutic outcomes melanoma-challenged mice fewer side effects when combined αPD-1. study suggests versatile biomanufacturing approach maximize minimize adverse advances design immunotherapy.
Язык: Английский
Процитировано
9
Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 12
Опубликована: Янв. 7, 2025
Uricase replacement therapy is a promising approach for managing hyperuricemia and gout but hindered by challenges such as short blood circulation time, reduced catalytic activity, excessive hydrogen peroxide (H2O2) production. These limitations necessitate innovative strategies to enhance therapeutic efficacy safety. We designed synthesized RBC@SeMSN@Uri, red cell-coated biomimetic self-cascade bioreactor, which encapsulates uricase (Uri) selenium-based nano-scavenger (SeMSN) within RBC membranes. This design aims reduce immunogenicity, extend systemic circulation, maintain enzymatic activity. In vitro assays were conducted evaluate biocompatibility, anti-inflammatory effects, oxidative stress protection. vivo experiments in models assessed efficacy, biodistribution, biosafety. RBC@SeMSN@Uri effectively degraded uric acid (UA) into allantoin converted H2O2 water, preventing damage inflammation. demonstrated excellent biocompatibility H2O2-induced inflammatory responses compared free uricase. vivo, the bioreactor prolonged significantly levels, alleviated kidney damage, mitigated symptoms of gout. It also targeted inflamed joints, reducing swelling inflammation gouty arthritis models. study presents novel strategy enzyme By integrating membranes, addresses key traditional therapies, offering enhanced stability, superior efficacy. platform holds potential broader applications protein or antibody delivery therapies other diseases.
Язык: Английский
Процитировано
0
Biomaterials, Год журнала: 2024, Номер 315, С. 122919 - 122919
Опубликована: Окт. 25, 2024
Язык: Английский
Процитировано
1
Science Advances, Год журнала: 2024, Номер 10(44)
Опубликована: Ноя. 1, 2024
Harnessing the immunogenic potential of senescent tumor cells provides an opportunity to remodel microenvironment (TME) and boost antitumor immunity. However, this needs be sophisticatedly wielded avoid additional immunosuppressive capacity cells. Our study shows that blocking JAK2/STAT3 pathway enhances efficacy Aurora kinase inhibitor alisertib (Ali)-induced senescence by reducing senescence-associated secretory phenotype (SASP) while preserving SASP. Hypothesizing SASP reprogramming with Ali JAK2 ruxolitinib (Rux) will benefit cancer immunotherapy, we create nanoparticulate crystals (Ali-Rux) composed Rux a fully active pharmaceutical ingredient. Immunization Ali-Rux-orchestrated promotes stronger activation antigen-presenting cells, enhancing immune surveillance. This approach remodels TME increasing CD8
Язык: Английский
Процитировано
1
Bioactive Materials, Год журнала: 2024, Номер 46, С. 347 - 364
Опубликована: Дек. 27, 2024
Язык: Английский
Процитировано
1
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 19, 2024
Cancer cell membrane-derived biomimetic nanovaccines have shown tremendous potential in cancer immunotherapy. However, their efficacy is restricted by the insufficient cross-presentation of membrane-associated antigens. Saposins (SAs), which are vital for membrane vesicle disintegration and antigen presentation, severely deficient antigen-presenting cells (APCs) within tumors. Herein, we propose a complementary strategy increasing via use SAs. Biomimetic were designed using shells to provide comprehensive array tumor-associated antigens reactive oxygen species (ROS)-responsive nanoparticle cores that allowed codelivery cytosine–guanine dinucleotides (CpGs) The ROS-responsive highly internalized APCs, enabled release CpGs SAs endo/lysosomes APCs. Furthermore, increased activation immunosuppressive APCs enhanced T-cell priming delivering Consequently, loaded with not only suppressed tumor growth but also exhibited excellent therapeutic effects combination immune checkpoint blockade strategies. Overall, our study provides insights into development integrating offers promising effective
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown
Опубликована: Дек. 4, 2024
The integration of theranostics, which combines diagnostics with therapeutics, has markedly improved the early detection diseases, precise medication management, and assessment treatment outcomes. In realm oncology, organoplatinum-based supramolecular coordination complexes (SCCs) that can coload therapeutic agents imaging molecules have emerged as promising candidates for multimodal theranostics tumors. To address challenges tumor-targeted delivery SCCs, this study employs a cell membrane cloaking strategy to fabricate biomimetic metallacage nanoparticles (MCNPs) capabilities homologous targeting capabilities. Specifically, photosensitizer molecule (BTTP) containing AIE-active groups was assembled into C-BTTP through Pt-N coordination. This process endows strong NIR-II fluorescence in aggregated state significantly superior ROS generation compared precursor ligand. After being encapsulated F127, MCNPs were further cloaked U87 cancer membranes, creating achieve tumor-targeting Verified by vitro vivo experiments, enable initiate immunotherapy under photothermal photodynamic stimulation, leading synergistic antitumor effects. Furthermore, evaluation immunogenic death dendritic maturation rate tumor-bearing mice confirmed mechanism immunotherapy. provides an innovative enhancing efficiency offering versatile efficient minimally invasive development such represents significant advancement field nanomedicine, potentially transforming personalized targeted therapies.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 289, С. 138620 - 138620
Опубликована: Дек. 13, 2024
Язык: Английский
Процитировано
0