2D MOFs nanosheets derived from 2D LDHs as a multifunctional sensitizer for sono-photodynamic therapy-mediated tumor treatment
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 159771 - 159771
Опубликована: Янв. 1, 2025
Язык: Английский
PAD4 Inhibitor‐Functionalized Layered Double Hydroxide Nanosheets for Synergistic Sonodynamic Therapy/Immunotherapy Of Tumor Metastasis
Advanced Science,
Год журнала:
2024,
Номер
11(26)
Опубликована: Май 6, 2024
Abstract
Sonodynamic
therapy
(SDT)
is
demonstrated
to
trigger
the
systemic
immune
response
of
organism
and
facilitate
treatment
metastatic
tumors.
However,
SDT‐mediated
neutrophil
extracellular
traps
(NETs)
formation
can
promote
tumor
cell
spread,
thus
weakening
therapeutic
effectiveness
Herein,
amorphous
CoW‐layered
double
hydroxide
(a‐CoW‐LDH)
nanosheets
are
functionalized
with
a
peptidyl
arginine
deiminase
4
(PAD4)
inhibitor,
i.e.,
YW3‐56,
construct
multifunctional
nanoagent
(a‐LDH@356)
for
synergistic
SDT/immunotherapy.
Specifically,
a‐CoW‐LDH
act
as
sonosensitizer
generate
abundant
reactive
oxygen
species
(ROS)
under
US
irradiation.
After
loading
a‐LDH@356
plus
irradiation
not
only
effectively
induces
ROS
generation
immunogenic
death,
but
also
inhibits
elevation
citrullinated
histone
H3
(H3cit)
release
NETs,
enabling
enhancement
anti‐tumor
metastasis
effect.
Using
4T1
model,
it
that
combining
YW3‐56
stimulates
an
by
upregulating
proportion
immune‐activated
cells
inducing
polarization
M1
macrophages,
escape
downregulating
expression
PD‐1
on
irradiation,
which
arrests
primary
progression
inhibition
rate
69.5%
prevents
least
number
lung
nodules.
Язык: Английский
Endogenous and exogeneous stimuli-triggered reactive oxygen species evoke long-lived carbon monoxide to fight against lung cancer
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 16, 2024
Abstract
Reactive
oxygen
species
(ROS)-associated
anticancer
approaches
usually
suffer
from
two
limitations,
i.e.,
insufficient
ROS
level
and
short
half-life.
Nevertheless,
no
report
has
synchronously
addressed
both
concerns
yet.
Herein,
a
multichannel
actions-enabled
nanotherapeutic
platform
using
hollow
manganese
dioxide
(H-MnO
2
)
carriers
to
load
chlorin
e6
(Ce6)
sonosensitizer
CO
donor
(e.g.,
Mn
(CO)
10
been
constructed
maximumly
elevate
trigger
cascade
catalysis
produce
CO.
Therein,
intratumoral
H
O
ultrasound
as
endogenous
exogeneous
triggers
stimulate
H-MnO
Ce6
•OH
1
,
respectively.
The
further
reaction
between
proceeds
release
CO,
converting
short-lived
into
long-lived
Contributed
by
them,
such
maximumly-elevated
accumulation
successfully
suppresses
the
progression,
recurrence
metastasis
of
lung
cancer
with
prolonged
survival
rate.
More
significantly,
proteomic
genomic
investigations
uncover
that
CO-induced
activation
AKT
signaling
pathway,
NRF-2
phosphorylation
HMOX-1
overexpression
induce
mitochondrial
dysfunction
boost
anti-tumor
consequences.
Thus,
this
strategy
can
behave
general
means
enrich
against
refractory
cancers.
Graphic
Язык: Английский
Charge separation engineering modulates self-oxygenating nano-heterojunctions to induce ferroptosis for sonodynamic-immunotherapy of tumors
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 160713 - 160713
Опубликована: Фев. 1, 2025
Язык: Английский
Membrane‐Anchoring and Oxygen‐Generating Mediated Nanosonosensitizer for Optimizing Cancer Immunotherapy
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Despite
its
antitumor
promise,
sonodynamic
therapy
(SDT)'s
efficacy
in
immune
activation
requires
enhancement,
primarily
due
to
the
hypoxic
tumor
microenvironment
(TME)
and
insufficient
targeting
of
sonosensitizers
specific
subcellular
regions.
Herein,
we
developed
macrophage
membrane
(MM)-intermingled
fusogenic
liposomes
(MFL)
optimize
sonoimmunotherapy
that
encapsulate
catalase
(CAT)
within
core
incorporate
sonosensitizer
chlorin
e6
(Ce6)
outer
shell
(CAT@MM-MFL-Ce6).
The
MM
confers
evasion
properties
promotes
nanoparticles'
targeted
accumulation
tissue.
fusion
effect
enables
Ce6
anchor
onto
cancer
cell
facilitates
direct
delivery
CAT
into
cytoplasm,
bypassing
endosomal
degradation.
Upon
ultrasound
stimulation,
generated
reactive
oxygen
species
directly
damage
plasma
membrane,
initiating
Caspase
3/Gasdermin
E-mediated
pyroptosis
pathway.
Concurrently,
encapsulated
efficiently
decompose
H₂O₂
thus
enhancing
local
levels
tumors.
Contributed
by
these
effects,
combination
nanosonosensitizer-augmented
SDT
checkpoint
agent
successfully
reverse
immunosuppressive
TME,
driving
a
potent
response
inhibits
primary
growth,
distant
metastasis,
lung
metastases
an
orthotopic
triple-negative
breast
model.
This
study
demonstrates
potential
novel
SDT-based
combinatorial
approach
modulate
immune-cold
TMEs,
advancing
proof-of-concept
therapeutics.
Язык: Английский
Responsive Theranostic Nanoprobe for Ratiometric Photoacoustic Monitoring of Hypochlorous Acid‐Mediated Inflammation in Cancer Photothermal Therapy
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 23, 2024
Abstract
Cancer
detection
and
inflammation
monitoring
during
photothermal
therapy
(PTT)
enable
timely
cancer
intervention
precise
control,
advancing
to
address
inflammation‐related
tumor
recurrence
metastasis
associated
with
PTT.
This
can
be
achieved
through
real‐time
biomarker
for
inflammation,
like
hypochlorous
acid
(HOCl),
a
highly
reactive
oxygen
species
(hROS)
in
body
elevated
levels
inflammation.
Here,
HOCl‐responsive
theranostic
nanoprobe
is
introduced,
AuNRs@SiO
2
‐CAA
ratiometric
photoacoustic
(PA)
emits
PA
signals
at
680
820
nm,
only
PA680
undergoing
changes
the
presence
of
HOCl,
enabling
HOCl
imaging
via
recording
(PA680/PA820).
exhibits
high
selectivity
sensitivity,
limit
0.34
µM
HOCl.
In
vivo,
it
effectively
detects
tumor,
drives
PTT,
monitors
PTT
by
sensing
The
successful
development
offers
novel
system
diagnosis,
poised
enhance
control.
Язык: Английский
A metal–phenolic nanotuner launches cancer pyroptosis for sono-immune therapy
Biomaterials Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 3, 2024
A
nanocoordinator
(HTA)
combining
Aza
and
TiO
2
induces
pyroptosis
by
restoring
GSDME
expression
generating
ROS
under
ultrasound.
This
strategy
enhances
anti-tumor
immunity
boosts
sonodynamic
therapy
efficacy
in
breast
cancer.
Язык: Английский
Inflammatory microenvironment-responsive “double-insurance” nanoreactors for accurate sonodynamic-chemodynamic therapy of rheumatoid arthritis
Chemical Engineering Journal,
Год журнала:
2024,
Номер
498, С. 155436 - 155436
Опубликована: Сен. 2, 2024
Язык: Английский
Nanotechnology for Nasopharyngeal Cancer Therapy and Improving Drug Stability and Biodistribution
Advanced Materials Technologies,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
Abstract
Nasopharyngeal
cancer
(NPC)
is
a
challenging
malignancy
with
poor
prognosis
due
to
late
diagnosis
and
resistance
conventional
treatments.
Nanotechnology
offers
promising
solutions
address
these
limitations
by
enabling
targeted
drug
delivery,
enhancing
therapeutic
efficacy,
facilitating
multimodal
treatment
strategies.
By
leveraging
the
unique
properties
of
nanomaterials
nanocarrier
systems,
innovative
approaches
for
early
detection,
treatment,
therapy
can
be
developed,
paving
way
more
effective
personalized
management
NPC.
This
review
provides
comprehensive
overview
recent
developments
applications
nanotechnology
in
NPC
therapy,
focusing
on
improving
stability,
biodistribution,
delivery
tumors.
Язык: Английский
Analysis of tumor treatment under interventional ultrasound through structural and temporal dynamics: a bibliometric visualization
Quantitative Imaging in Medicine and Surgery,
Год журнала:
2024,
Номер
14(12), С. 8899 - 8914
Опубликована: Ноя. 21, 2024
Ultrasound
is
considered
one
of
the
most
crucial
tools
for
image-guided
tumor
ablation,
and
provides
a
vital
alternative
approach
to
treatment.
This
study
used
bibliometric
methods
characterize
development
history
treatment
under
interventional
ultrasound
explore
future
research
hotspots.
In
this
study,
we
retrieved
selected
publications
on
from
Web
Science
Core
Collection
(WoSCC)
database
published
1960
2023.
total,
2,588
articles
were
included
in
our
study.
A
analysis
was
conducted
various
aspects
field,
such
as
global
publication
trends,
institutional
author
collaborations,
high-impact
journals,
highly
cited
publications,
evolution
Our
results
revealed
that
output
field
has
continuously
increased
over
past
few
decades
with
China
United
States
emerging
active
contributors
maintaining
close
collaborative
relationships.
Several
institutions
authors,
including
Chongqing
Medical
University,
had
high
volume,
citation
counts,
number
collaborations
field.
Journals
like
"Journal
Urology"
"Ultrasound
Medicine
Biology"
have
enriched
literature
resources
fostered
developments
addition,
keyword
main
focus
areas
Based
analysis,
found
shifted
exploration
clinical
applications
technological
advancements
safety.
also
historical
trajectory
identified
trends
Язык: Английский