Metal‐organic frameworks‐based nanomedicines to promote cancer immunotherapy: Recent advances and future directions

MedComm – Biomaterials and Applications, Год журнала: 2024, Номер 3(4)

Опубликована: Окт. 19, 2024

Abstract Cancer immunotherapy uses the body's immune system to fight tumors by restoring natural antitumor responses. Metal‐organic frameworks (MOFs), characterized their unique crystalline porous structures formed from metal ions linked organic ligands, offer a promising solution. Recent studies have unveiled potential of MOFs in cancer immunotherapy. The exceptional porosity and surface area, coupled with extraordinary thermal chemical stability, bring significant advantages for efficient drug loading delivery immunotherapeutic agents. adaptability further enhances controlled release drugs within target cells increases tumor sensitivity other therapies such as photodynamic, photothermal, radiotherapy. This multifunctional carrier contributes modulating microenvironment reactivating immunity, providing comprehensive strategy treatment. In this review, we summarize applications checkpoint blockade, immunomodulator delivery, vaccine discuss existing challenges use discussion aims insights developing better treatments enhancing efficacy

Язык: Английский

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Precise Pore Structure Regulation of an Oxalate-Functionalized Metal–Organic Framework for Efficient Carbon Dioxide Sieving with High Capacity

Industrial & Engineering Chemistry Research, Год журнала: 2024, Номер 63(46), С. 20365 - 20372

Опубликована: Ноя. 11, 2024

Adsorptive separation of carbon dioxide from methane is a crucial process for natural gas and biogas upgrading. Designing porous materials with both high CO2 uptake capacity selectivity remains challenging. Herein, we realized the efficient sieving CH4 CO2, adsorption (4.54 mmol/g at 298 K 5 bar), by an oxalate-functionalized metal–organic framework ZU-301a decorated high-density oxalate anions hydrophobic methyls. Specifically, featuring regularly layered three-dimensional configuration was obtained facile post-treatment previous material ZU-301 spiral pore structure. exhibited improved porosity narrower size via precise regulation, leading to 69% increase in bar. Breakthrough experiments further confirmed superior ability CO2/CH4 under various temperature conditions. A dual-bed six-step vacuum pressure swing (VPSA) simulation designed, 99.59% purity as well recovery rate (98.01%) (50/50) mixture. Additionally, DFT calculations revealed that strong binding mainly due electrostatic interactions C(δ+) on molecules O(δ–) oxalic acid. These findings not only demonstrate regulation strategy build ultramicroporous frameworks but also suggest potential use VPSA

Язык: Английский

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Efficient capture of gaseous, aqueous iodine, near-sunlight white light emission and iodine sensing in 12-connected and [Pb6]-cluster based MOFs

Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 158782 - 158782

Опубликована: Дек. 1, 2024

Язык: Английский

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Efficient Iodine Sequestration by Chemically Robust C-C Bonded Hyper-Crosslinked Porous Organic Polymers

Chemical Engineering Journal Advances, Год журнала: 2024, Номер unknown, С. 100700 - 100700

Опубликована: Дек. 1, 2024

Язык: Английский

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