Genetically Engineered Membrane‐Coated Nanoparticles for Enhanced Prostate‐Specific Membrane Antigen Targeting and Ferroptosis Treatment of Castration‐Resistant Prostate Cancer

Advanced Science, Год журнала: 2024, Номер 11(33)

Опубликована: Июль 1, 2024

Conventional androgen deprivation therapy (ADT) targets the receptor (AR) inhibiting prostate cancer (PCa) progression; however, it can eventually lead to recurrence as castration-resistant PCa (CRPC), which has high mortality rates and lacks effective treatment modalities. The study confirms presence of glutathione peroxidase 4 (GPX4) expression, a key regulator ferroptosis (i.e., iron-dependent program cell death) in CRPC cells. Therefore, inducing cells might be an therapeutic modality for CRPC. However, nonspecific uptake inducers result undesirable cytotoxicity major organs. Thus, precisely induce cells, genetic engineering strategy is proposed embed prostate-specific membrane antigen (PSMA)-targeting antibody fragment (gy1) macrophage membrane, then coated onto mesoporous polydopamine (MPDA) nanoparticles produce biomimetic nanoplatform. results indicate that membrane-coated (MNPs) exhibit specificity affinity toward On further encapsulation with RSL3 iron ions, MPDA/Fe/RSL3@M-gy1 demonstrates superior synergistic effects highly targeted eliciting significant efficacy against tumor growth bone metastasis without increased cytotoxicity. In conclusion, new reported PSMA-specific, CRPC-targeting platform induction safety.

Язык: Английский

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Boronate affinity-mediated multi-mode visual sensing of cis-diol compounds in both biological and food samples

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137335 - 137335

Опубликована: Янв. 1, 2025

Язык: Английский

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Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 7, 2025

Язык: Английский

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Cell membrane nanoparticles in cancer therapy: From basic structure to surface functionalization

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113752 - 113752

Опубликована: Апрель 1, 2025

Язык: Английский

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Novel hollow ultrasound-triggered ZnFe2O4-Bi2MoO6 S-scheme heterojunction for efficient ferroptosis-based tumor therapy

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 683, С. 132 - 146

Опубликована: Дек. 10, 2024

Язык: Английский

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