Reactive Oxygen Species‐Responsive Nanoparticles Toward Extracellular Matrix Normalization for Pancreatic Fibrosis Regression
Advanced Science,
Год журнала:
2024,
Номер
11(19)
Опубликована: Март 14, 2024
Abstract
Pancreatic
fibrosis
(PF)
is
primarily
characterized
by
aberrant
production
and
degradation
modes
of
extracellular
matrix
(ECM)
components,
resulting
from
the
activation
pancreatic
stellate
cells
(PSCs)
pathological
cross‐linking
ECM
mediated
lysyl
oxidase
(LOX)
family
members.
The
excessively
deposited
increases
stiffness,
over‐accumulated
reactive
oxygen
species
(ROS)
induces
oxidative
stress,
which
further
stimulates
continuous
PSCs
advancing
PF;
challenging
strategy
toward
normalizing
homeostasis
for
regression
PF.
Herein,
ROS‐responsive
Vitamin
A
(VA)
decorated
micelles
(named
LR‐SSVA)
to
reverse
imbalanced
ameliorating
PF
are
designed
synthesized.
Specifically,
LR‐SSVA
selectively
targets
via
VA,
thereby
effectively
delivering
siLOXL1
resveratrol
(RES)
into
pancreas.
released
RES
inhibits
overproduction
eliminating
ROS
inactivating
PSCs,
meanwhile,
decreased
expression
LOXL1
ameliorates
cross‐linked
collagen
easier
collagenase
jointly
normalizes
alleviates
This
research
shows
that
a
safe
efficient
ROS‐response
PSC‐targeted
drug‐delivery
system
normalization,
will
propose
an
innovative
ideal
platform
reversal
Язык: Английский
Pancreatic stellate cell: Update on molecular investigations and clinical translation in pancreatic cancer
International Journal of Cancer,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 18, 2025
Pancreatic
cancer
is
a
particularly
aggressive
tumor,
distinguished
by
the
presence
of
prominent
collagenous
stroma
and
desmoplasia
that
envelops
tumor
cells.
stellate
cell
(PSC)
contributes
to
formation
dense
fibrotic
has
been
demonstrated
facilitate
progression.
As
significance
PSCs
increasingly
revealed,
more
explorations
are
focused
on
complex
molecular
mechanisms
tumor-stromal
crosstalk
in
order
guide
potential
therapeutic
approaches
through
deactivating
or
reprogramming
PSCs.
Nevertheless,
significant
challenges
persist
translating
preclinical
discoveries
into
clinical
applications.
In
this
review,
we
expect
offer
comprehensive
overview
latest
advancements
PSCs,
along
with
new
insights
strategies
targeting
Язык: Английский
Fertile Ground for Homeostatic Reformation: Engineered Release Platforms for Enhanced Regenerative Outcomes
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
106, С. 106740 - 106740
Опубликована: Фев. 21, 2025
Язык: Английский
Piezoelectric nanofilms fabricated by coaxial electrospun polycaprolactone/Barium titanate promote Achilles tendon regeneration by reducing IL-17A/NF-κB-mediated inflammation
Bioactive Materials,
Год журнала:
2025,
Номер
49, С. 1 - 22
Опубликована: Март 1, 2025
Язык: Английский
Engineered MSCs Break Endothelial‐Myofibroblast Crosstalk in Pulmonary Fibrosis: Reconstructing the Vascular Niche
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 28, 2025
Abstract
In
the
progress
of
pulmonary
fibrosis
(PF),
normal
vascular
niche
plays
a
crucial
role
in
alveolar
regeneration
by
secreting
angiocrine
factors.
However,
malignant
interaction
between
myofibroblasts
and
endothelial
cells
results
significant
loss
capillaries
fibroblast
foci,
which
promotes
continuous
deterioration
fibrosis.
Herein,
an
engineered
mesenchymal
stem
cell
(MSC)
therapeutic
named
MSC‐MM@LPHN
is
developed
for
reconstructing
niche,
formed
modifying
surface
MSC
with
ROS‐responsive
lipid
polymeric
hybrid
nanoparticles
encapsulating
metformin
macitentan.
Due
to
homing
ability
MSC,
can
effectively
target
lung
tissue,
then
induce
myofibroblast
dedifferentiation
reduce
secretion
cytokines
that
cause
damage
preventing
from
turning
into
fibrotic
phenotype,
leading
recovery
function.
Combined
MSC‐secreted
growth
factors
promoting
angiogenesis,
ultimately
constructs
structure
area
reverses
bleomycin‐induced
PF.
The
findings
suggest
targeting
network
treat
PF,
provides
novel
strategy
fibrosis‐related
diseases.
Язык: Английский
Bone marrow microenvironment-targeted yolk-shell nanoparticle enhances acute myeloid leukemia chemotherapy by preventing endothelial cell/ECM-mediated adhesion
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 164084 - 164084
Опубликована: Май 1, 2025
Язык: Английский
Neutrophils inhibit bone formation by directly contacting osteoblasts and suppressing osteogenic differentiation
Yijun Liu,
Fengyuan Guo,
Zhenshuo Han
и другие.
Bone,
Год журнала:
2024,
Номер
190, С. 117310 - 117310
Опубликована: Окт. 30, 2024
Язык: Английский
The Application of Nanomaterials in the Treatment of Pancreatic-Related Diseases
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 13158 - 13158
Опубликована: Дек. 7, 2024
Pancreatic
diseases,
typically
including
pancreatic
cancer,
pancreatitis,
and
diabetes,
pose
enormous
threats
to
people's
lives
health.
To
date,
therapeutics
with
high
therapeutic
efficacy
low
side
effects
are
still
challenging.
With
the
development
of
nanotechnology,
nanomaterials
have
successfully
been
applied
in
pancretic
disease
treatment.
Here,
we
first
introduce
diversity
their
different
physicochemical
properties
on
function.
Following
this,
analyze
potential
enhance
targeting
by
overcoming
challenges
traditional
delivery
methods
through
surface
modifications,
structural
adjustments,
optimized
drug
loading.
Then,
application
structurally
pancreatic-related
diseases.
For
instance,
cancer
(as
platforms,
for
promotion
radiation
therapy,
as
multifunctional
tools),
pancreatitis
systems,
anti-inflammatory
anti-fibrotic
agents),
diabetes
insulin
carriers,
protecting
β
cells,
improving
resistance).
Through
analysis
progress
current
research,
summarize
how
can
treatment
while
minimizing
effects.
Finally,
look
forward
prospects
Язык: Английский
Plasma-Activated Medium Inhibited the Proliferation and Migration of Non-Small Cell Lung Cancer A549 Cells in 3D Culture
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13262 - 13262
Опубликована: Дек. 10, 2024
Lung
cancer
is
the
most
common
type
of
malignant
tumor
worldwide.
Plasma-activated
medium
(PAM)
an
innovative
treatment
method
that
has
received
considerable
scientific
attention.
The
objective
this
study
to
evaluate
effects
PAM
on
anti-tumor
characteristics
non-small
cell
lung
(NSCLC)
cells
in
two-dimensional
(2D)
and
three-dimensional
(3D)
cultures.
proliferative
migratory
capabilities
A549
2D
3D
cultures
were
assessed
using
MTT,
migration,
invasion
assays,
cycle,
respectively.
also
investigated
impact
changes
content
intracellular
extracellular
reactive
species
analyzed
protein
expression
Western
Blot
method.
inhibited
viability,
abilities
both
cultures,
suppressed
epithelial–mesenchymal
transition
(EMT)
process,
downregulated
RAS/ERK
signaling
pathway,
which
effectively
spheroid
formation.
Additionally,
effect
was
mediated
through
ROS-induced
oxidative
reactions,
exhibited
greater
cytotoxicity
culture
compared
culture.
As
2D,
model
provides
a
viable
vitro
for
studying
mechanisms
cancer.
represents
effective
new
NSCLC.
Язык: Английский