Developing fibrin-based biomaterials/scaffolds in tissue engineering
Bioactive Materials,
Год журнала:
2024,
Номер
40, С. 597 - 623
Опубликована: Авг. 15, 2024
Tissue
engineering
technology
has
advanced
rapidly
in
recent
years,
offering
opportunities
to
construct
biologically
active
tissues
or
organ
substitutes
repair
even
enhance
the
functions
of
diseased
and
organs.
Tissue-engineered
scaffolds
rebuild
extracellular
microenvironment
by
mimicking
matrix.
Fibrin-based
possess
numerous
advantages,
including
hemostasis,
high
biocompatibility,
good
degradability.
Fibrin
provide
an
initial
matrix
that
facilitates
cell
migration,
differentiation,
proliferation,
adhesion,
also
play
a
critical
role
cell-matrix
interactions.
are
now
widely
recognized
as
key
component
tissue
engineering,
where
they
can
facilitate
defect
repair.
This
review
introduces
properties
fibrin,
its
composition,
structure,
biology.
In
addition,
modification
cross-linking
modes
fibrin
discussed,
along
with
various
forms
commonly
used
engineering.
We
describe
biofunctionalization
fibrin.
provides
detailed
overview
use
applications
skin,
bone,
nervous
tissues,
novel
insights
into
future
research
directions
for
clinical
treatment.
Язык: Английский
Mechanically optimized hydrogel enhances functional recovery after spinal cord injury
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 163575 - 163575
Опубликована: Май 1, 2025
Язык: Английский
Tissue‐Penetrating Ultrasound‐Triggered Hydrogel for Promoting Microvascular Network Reconstruction
Advanced Science,
Год журнала:
2024,
Номер
11(23)
Опубликована: Апрель 10, 2024
Abstract
The
microvascular
network
plays
an
important
role
in
providing
nutrients
to
the
injured
tissue
and
exchanging
various
metabolites.
However,
how
achieve
efficient
penetration
of
is
bottleneck
restricting
reconstruction
network.
Herein,
hydrogel
precursor
solution
can
efficiently
penetrate
damaged
area,
ultrasound
triggers
release
thrombin
from
liposomes
hydrolyze
fibrinogen,
forming
a
fibrin
solid
situ
with
calcium
ions
transglutaminase
as
catalysts,
effectively
solving
impedance
tissues
ultimately
significantly
promoting
formation
networks
within
tissues.
First,
fibrinogen
complex
permeated
into
tissue.
Second,
triggered
thrombin,
activates
transglutaminase,
hydrolyzes
fibrinogen.
Third,
monomers
are
catalyzed
form
hydrogels
area.
In
vitro
studies
have
shown
that
penetrated
artificial
bone
15
s
after
ultrasonic
triggering,
formed
continuous
triggering
for
30
s.
Overall,
this
innovative
strategy
solved
problem
resistance
ultrasound‐triggered
tissues,
finally
regeneration.
Язык: Английский