Multiparametric Brain Hemodynamics Imaging Using a Combined Ultrafast Ultrasound and Photoacoustic System
Advanced Science,
Год журнала:
2024,
Номер
11(31)
Опубликована: Июнь 17, 2024
Abstract
Studying
brain‐wide
hemodynamic
responses
to
different
stimuli
at
high
spatiotemporal
resolutions
can
help
gain
new
insights
into
the
mechanisms
of
neuro‐
diseases
and
‐disorders.
Nonetheless,
this
task
is
challenging,
primarily
due
complexity
neurovascular
coupling,
which
encompasses
interdependent
parameters
including
cerebral
blood
volume
(CBV),
flow
(CBF),
oxygen
saturation
(SO
2
).
The
current
brain
imaging
technologies
exhibit
inherent
limitations
in
resolution,
sensitivity,
depth,
restricting
their
capacity
comprehensively
capture
intricacies
functions.
To
address
this,
a
multimodal
functional
ultrasound
photoacoustic
(fUSPA)
platform
reported,
integrates
ultrafast
multispectral
methods
compact
head‐mountable
device,
quantitatively
map
individual
dynamics
CBV,
CBF,
SO
as
well
contrast
agent
enhanced
resolutions.
Following
systematic
characterization,
fUSPA
system
applied
study
cerebrovascular
reactivity
(CVR)
single‐vessel
resolution
via
relative
changes
response
hypercapnia
stimulation.
These
results
show
that
cortical
veins
arteries
differences
CVR
stimulated
state
consistent
anti‐correlation
CBV
oscillations
during
resting
state,
demonstrating
multiparametric
system's
unique
capabilities
investigating
complex
Язык: Английский
Label‐Free Dual‐Modal Photoacoustic/Ultrasound Localization Imaging for Studying Acute Kidney Injury
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 11, 2025
Abstract
Growing
evidence
suggests
a
close
link
between
acute
kidney
injury
(AKI)
and
disruptions
in
renal
microcirculation.
However,
current
non‐invasive
tools
for
quantitatively
monitoring
structural
functional
changes
microcirculation
remain
limited,
making
early
diagnosis
difficult.
To
address
this
challenge,
work
introduces
label‐free
3D
multi‐parametric
imaging
technique
that
combines
photoacoustic
super‐resolution
ultrasound
imaging.
This
approach
provides
high‐resolution
information
on
vasculature,
hemodynamics,
oxygenation.
system
offers
the
ability
to
visualize
entire
vasculature
at
resolution
of
26
µm.
In
an
AKI
model,
demonstrates
54%
reduction
vascular
density,
14.1%
decrease
oxygenation,
61%
decline
relative
blood
volume
(rBV)
3
days
post‐surgery.
The
progression
disease
is
further
confirmed
through
tests
histopathological
analysis
collected
tissues.
These
findings
indicate
holds
substantial
potential
advance
understanding
physiology
valuable
tool
investigating
injury.
Язык: Английский
Enhanced diagnostic accuracy of contrast-enhanced ultrasound in liver space-occupying lesions: superior sensitivity and specificity over conventional ultrasound
American Journal of Cancer Research,
Год журнала:
2025,
Номер
15(3), С. 1201 - 1212
Опубликована: Янв. 1, 2025
To
evaluate
the
clinical
value
of
contrast-enhanced
ultrasound
(CEUS)
in
diagnosing
liver
space-occupying
lesions.
A
total
487
patients
with
lesions
were
examined
using
both
conventional
and
CEUS.
The
diagnostic
results
from
two
methods
compared,
pathological
findings
used
as
gold
standard.
Sensitivity,
specificity,
positive
predictive
(PPV),
negative
(NPV),
area
under
receiver
operating
characteristic
curve
calculated
for
each
method
to
assess
their
value.
Among
lesions,
220
malignant
267
benign.
relative
blood
flow
(rBF)
arterial
phase
was
significantly
higher
than
that
benign
while
rBF
delayed
lower
(P<0.05).
In
CEUS
had
a
detection
rate
(75%
vs.
43.18%,
P<0.001).
also
demonstrated
agreement
≤1
cm
compared
(85.16%
49.47%,
accuracy,
sensitivity,
PPV,
NPV
all
those
(all
P<0.05).
is
effective
superior
sensitivity
specificity
ultrasound.
Язык: Английский
Photoacoustic Imaging Detects Cerebrovascular Pathological Changes in Sepsis
Photoacoustics,
Год журнала:
2025,
Номер
unknown, С. 100737 - 100737
Опубликована: Май 1, 2025
Язык: Английский
In vivo, online label-free monitoring of heterogenous oxygen utilization during phototherapy with real-time ultrasound-guided photoacoustic imaging
Andrew Langley,
Allison Sweeney,
Ronak Tarun Shethia
и другие.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 3, 2024
Understanding
the
tumor
microenvironment,
particularly
vascular
density
and
availability
of
oxygen,
is
key
in
individualizing
treatment
approaches
determining
their
efficacy.
While
there
are
many
therapies
including
radiotherapy
that
ineffective
hypoxic
microenvironments,
here
we
demonstrate
heterogeneous
oxygen
consumption
during
photodynamic
therapy
(PDT),
a
non-invasive
method
using
localized
light
to
activate
photosensitive
drug
presence
has
shown
high
effectiveness
various
types
tumors,
those
presented
head
neck
cancer
(HNC)
patients.
our
previous
work
demonstrated
blood
saturation
(StO
Язык: Английский