Optimizing the screening process for inhibitory aptamers specific to folate receptor alpha on an integrated, shear force-controlling microfluidic system DOI Creative Commons

Yi-Cheng Tsai,

Yang-Sheng Shao,

Chih‐Hung Wang

и другие.

Chemical Engineering Journal Advances, Год журнала: 2024, Номер 20, С. 100681 - 100681

Опубликована: Ноя. 1, 2024

Язык: Английский

Advancements in Aptamer‐Driven DNA Nanostructures for Precision Drug Delivery DOI Creative Commons
Moein Safarkhani, Sepideh Ahmadi,

Hossein Ipakchi

и другие.

Advanced Science, Год журнала: 2024, Номер 11(26)

Опубликована: Май 7, 2024

Abstract DNA nanostructures exhibit versatile geometries and possess sophisticated capabilities not found in other nanomaterials. They serve as customizable nanoplatforms for orchestrating the spatial arrangement of molecular components, such biomolecules, antibodies, or synthetic This is achieved by incorporating oligonucleotides into design nanostructure. In realm drug delivery to cancer cells, there a growing interest active targeting assays enhance efficacy selectivity. The approach involves “key‐lock” mechanism where carrier, through its ligand, recognizes specific receptors on tumor facilitating release drugs. Various nanostructures, including origami, Tetrahedral, nanoflower, cruciform, nanostar, nanocentipede, nanococklebur, can traverse lipid layer cell membrane, allowing cargo nucleus. Aptamers, easily formed vitro, are recognized their targeted due high selectivity targets low immunogenicity. review provides comprehensive overview recent advancements formation modification aptamer‐modified within systems.

Язык: Английский

Процитировано

18

Role of homonuclear B–B/N–N bonds in DNA nucleobases adsorption on boron nitride fullerenes: Biosensor and drug transport implications DOI

Gabriel García-Laiton,

Fernando Arcenio Zubieta López, Ehsan Shakerzadeh

и другие.

Computational and Theoretical Chemistry, Год журнала: 2025, Номер unknown, С. 115188 - 115188

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1

Exploring metal-organic frameworks in gene delivery: From prostate to lung therapeutics DOI
Moein Safarkhani, Nasim Dana,

Fahimeh Taghavimandi

и другие.

Applied Materials Today, Год журнала: 2024, Номер 41, С. 102449 - 102449

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

5

SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials DOI Creative Commons
Qian Cai, Rui Guo, Dafu Chen

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 6, 2025

Synthetic biology and nanotechnology fusion represent a transformative approach promoting fundamental clinical biomedical science development. In SynBioNanoDesign, biological systems are reimagined as dynamic programmable materials to yield engineered nanomaterials with emerging specific functionalities. This review elucidates comprehensive examination of synthetic biology's pivotal role in advancing for targeted drug delivery systems. It begins exploring the synergy between nanotechnology, then highlights current landscape applications. Subsequently, discusses design novel informed by principles, focusing on expounding tools potential developing advanced nanomaterials. Afterward, research advances innovative through were systematically summarized, emphasizing integration genetic circuitry program nanomaterial responses. Furthermore, challenges, weaknesses opportunities, prospective directions, ethical societal implications SynBioNanoDesign elucidated. Finally, summarizes impact that may have drug-delivery technologies future.

Язык: Английский

Процитировано

0

QKCMP peptide carrier macromolecule structure and release system based on triangular DNA origami nanostructures: A novel strategy for promoting angiogenesis DOI
Haifeng Wang, Yi Huang, Chenhui Zhou

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 310, С. 143457 - 143457

Опубликована: Апрель 25, 2025

Язык: Английский

Процитировано

0

Synthesis with Control of DNA Nanoflowers towards Biomedical Applications DOI Creative Commons

Nsolo M. Maarifa,

Fahim El-Kassim M. Issimail,

He Jian

и другие.

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101886 - 101886

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

DNA Origami‐Based CD44‐Targeted Therapy Silences Stat3 Enhances Cartilage Regeneration and Alleviates Osteoarthritis Progression DOI Creative Commons
Qi Lv, Xiang Zhao,

Songsong Teng

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Май 21, 2025

Abstract Osteoarthritis (OA) is a widespread musculoskeletal disorder affecting ≈600 million people globally, and small interfering RNA (siRNA) therapy shows potential in targeting OA progression. However, the efficient targeted delivery of siRNA remains major challenge due to issues with tissue specificity degradation vivo. In this study, A DNA origami‐based chondrocyte‐targeted system (OCS) designed for OA‐affected cartilage. The origami engineered load signal transducer activator transcription 3 (Stat3), key regulator inflammation cartilage degradation, functionalized anti‐CD44 aptamers selective chondrocytes. vitro, effectively delivers diseased chondrocytes, silencing matrix metalloproteinases expression reducing inflammation. rat models, it preserves integrity, promotes regeneration, mitigates ECM without evident side effects. These findings highlight as promising platform siRNA‐based therapy, offering solution challenges delivery.

Язык: Английский

Процитировано

0

Unraveling the advances of non-coding RNAs on the tumor microenvironment: innovative strategies for cancer therapies DOI Creative Commons
Di Mu, Bing Han, Yi Luo

и другие.

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Июнь 2, 2025

Non-coding RNAs (ncRNAs) are crucial molecules that do not encode proteins but play roles in regulating various biological processes. Recent research highlights ncRNAs only control gene expression within cells also facilitate intercellular communication via exosomes and other carriers. This function is vital the tumor microenvironment (TME). Our review covers structure functions of different ncRNAs, such as microRNAs (miRNAs), long non-coding (lncRNAs), circular (circRNAs). We examine how these influence initiation progression. Additionally, we explore their role promoting growth or immune evasion by modulating TME. The potential using therapeutic targets biomarkers for clinical use discussed. As our understanding grows, development new therapies based on anticipated to offer improved treatment options cancer patients.

Язык: Английский

Процитировано

0

DNA-mediated self-assembly oxidative damage amplifier combined with copper and MTH1 inhibitor for cancer therapy DOI

Cui Ren,

Zhiyong Shi, Xiaowen Zhang

и другие.

Bioactive Materials, Год журнала: 2024, Номер 45, С. 434 - 445

Опубликована: Дек. 3, 2024

Язык: Английский

Процитировано

2

MXene-based Aptasensors: A perspective on recent advances DOI
Navid Rabiee, Mohammad Rabiee

Nanoscale, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Recent advancements in science and technology have significantly enhanced public health by integrating novel materials early diagnostic methods.

Язык: Английский

Процитировано

1