The key role of the ferroptosis mechanism in neurological diseases and prospects for targeted therapy

Frontiers in Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Май 12, 2025

Neurological disorders represent a major global health concern owing to their intricate pathological processes. Ferroptosis, defined as form of cell death that is reliant on iron, has been closely linked various neurological conditions. The fundamental process underlying ferroptosis by the excessive buildup iron ions, which initiates lipid peroxidation processes leading cellular demise. Neurons, highly metabolically active cells, are susceptible oxidative stress, and imbalances in metabolism can directly initiate process. In neurodegenerative like Alzheimer's disease Parkinson's disease, driven accumulation represents connection. Although connection between diseases clear, clinical application still faces challenges, such precise regulation metabolism, development specific drugs, assessment efficacy. limited comprehension mechanism hinders personalized treatment approaches. Consequently, subsequent investigations must tackle these obstacles facilitate ferroptosis-associated therapies disorders. This article provides comprehensive overview most recent advancements regarding mechanisms ferroptosis. Subsequently, study investigates mechanistic contributions within nervous system. conclusion, we evaluate deliberate targeted therapeutic strategies associated with

Язык: Английский

Direct reprogramming of fibroblasts into spiral ganglion neurons by defined transcription factors

Cell Proliferation, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 17, 2024

Abstract Degeneration of the cochlear spiral ganglion neurons (SGNs) is one major causes sensorineural hearing loss and significantly impacts outcomes implantation. Functional regeneration SGNs holds great promise for treating loss. In this study, we systematically screened 33 transcriptional regulators implicated in neuronal SGN fate. Using gene expression array principal component analyses, identified a sequential combination Ascl1, Pou4f1 Myt1l (APM) promoting functional reprogramming SGNs. The induced by APM expressed mature lineage‐specific markers, displayed SGN‐like electrophysiological characteristics exhibited single‐cell transcriptomes resembling endogenous Thus, transcription factors may serve as novel candidates direct recovery due to damages.

Язык: Английский