Metabolism Open, Год журнала: 2024, Номер 24, С. 100327 - 100327
Опубликована: Окт. 30, 2024
Язык: Английский
Advanced Science, Год журнала: 2024, Номер 11(39)
Опубликована: Авг. 19, 2024
Abstract Regulating cardiolipin to maintain mitochondrial homeostasis is a promising strategy for addressing Parkinson's disease (PD). Through comprehensive screening and validation process involving multiple models, ginsenoside Rg3 (Rg3) as compound capable of enhancing levels identified. This augmentation in fosters by bolstering unfolded protein response, promoting mitophagy, oxidative phosphorylation. Consequently, this cascade enhances the survival tyrosine hydroxylase positive (TH + ) dopaminergic neurons, leading an amelioration motor performance within PD mouse models. Using limited proteolysis–small‐molecule mapping combined with molecular docking analysis, it has confirmed Growth Factor Receptor‐Bound Protein 2 (GRB2) target Rg3. Furthermore, these investigations reveal that facilitates interaction between GRB2 TRKA (Neurotrophic Tyrosine Kinase, Receptor, Type 1), thus promotes EVI1 (Ecotropic Virus Integration Site 1 Homolog) phosphorylation ERK, subsequently increases CRLS1 (Cardiolipin Synthase 1) gene expression boosts synthesis. The absence or significantly attenuates beneficial effects on symptoms. Finally, Tenofovir Disoproxil Fumarate (TDF) also binding further identified compounds, TDF, exhibit potential prevention reinstating homeostasis.
Язык: Английский
Процитировано
4
Pharmacological Research, Год журнала: 2025, Номер 212, С. 107578 - 107578
Опубликована: Янв. 5, 2025
Ginseng has been commonly used as a traditional Chinese medicine in Asian countries for thousands of years. Ginsenosides are the main pharmacologically active ingredients isolated from ginseng and have neuroprotective effects treatment neurodegenerative disorders, such Parkinson's disease (PD) Alzheimer's (AD). To summarise investigate protective roles ginsenosides their underlying mechanisms PD AD, we ''Ginsenoside", ''Parkinson's disease", ''Alzheimer's ''anti-inflammatory", ''antioxidant", ''apoptosis" keywords to search extract relevant literature information scientific databases Elsevier, PubMed, Google Scholar databases. In particular, network pharmacology identify potential targets Rg1 Rb1 AD. By analysing existing research advances results, found that ginsenosides, primarily mediated through anti-inflammation, anti-apoptosis anti-oxidative stress, etc, may be associated with PI3K/Akt, BDNF/TrkB, MAPKs, NF-κB, Nrf2 Wnt/β-catenin signalling pathways. This review systematically summarises different Rg1, Rb1, rare AD provides new strategies disorders. Network paradigm using Rb1.
Язык: Английский
Процитировано
0
Diabetes Obesity and Metabolism, Год журнала: 2024, Номер unknown
Опубликована: Окт. 30, 2024
Abstract Growth factor receptor‐bound protein 2 (GRB2) is a key adaptor involved in multiple signalling pathways, and its dysregulation associated with various diseases. Type diabetes systemic condition characterized by insulin resistance impaired β‐cell function. The complications of significantly reduce life expectancy quality life, imposing substantial burden on society. However, the role GRB2 largely unknown. Emerging evidence suggests that plays crucial resistance, inflammation, immune activation regulation cellular processes such as cell proliferation, growth, metabolism, angiogenesis, apoptosis differentiation. Dysregulation GRB2‐mediated pathways contributes to progression diabetic neuropathy, cognitive dysfunction, nephropathy, retinopathy related disorders. This review provides comprehensive overview current understanding diabetes, disorders, alongside recent advances development GRB2‐targeted therapies. Elucidating complex these disorders valuable insights into potential therapeutic strategies targeting pathways.
Язык: Английский
Процитировано
1
Metabolism Open, Год журнала: 2024, Номер 24, С. 100327 - 100327
Опубликована: Окт. 30, 2024
Язык: Английский
Процитировано
0