A Size-Adaptive Nanomicrobicide for Synergistic Photothermal and Gaseous Dismantling of Multidrug-Resistant Biofilms
Nano Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
Biofilms
significantly
impede
the
efficacy
of
conventional
antimicrobial
agents,
particularly
in
multidrug-resistant
(MDR)
infections.
In
this
work,
we
developed
a
size-adaptive,
bismuth-based
nanomicrobicide
encapsulated
with
neutrophil
membranes
(Bi2S3/SNP@CM),
designed
to
selectively
generate
nitric
oxide
(NO)
within
acidic
biofilms
under
near-infrared
(NIR)
irradiation.
The
nanomicrobicide's
adaptive
size
ensures
deeper
biofilm
penetration
and
accumulation,
while
membrane
coating
enhances
biocompatibility
targeting
at
infection
sites.
Upon
NIR
irradiation,
localized
heating
NO
release
synergistically
eradicate
MDR
biofilms.
Furthermore,
interactions
between
glutathione,
as
well
reactions
ROS,
disrupt
intracellular
redox
balance,
further
amplifying
antibacterial
efficacy.
This
innovative
design
affords
promising
for
effectively
treating
Язык: Английский
Photoresponsive Multirole Nanoweapon Camouflaged by Hybrid Cell Membrane Vesicles for Efficient Antibacterial Therapy of Pseudomonas aeruginosa‐Infected Pneumonia and Wound
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 15, 2024
Exploring
effective
antibacterial
approaches
for
targeted
treatment
of
pathogenic
bacterial
infections
with
reduced
drug
resistance
is
great
significance.
Combinational
modality
that
leverages
different
therapeutic
components
can
improve
the
overall
effectiveness
and
minimize
adverse
effects,
thus
displaying
considerable
potential
against
infections.
Herein,
red
blood
cell
membrane
fuses
macrophage
to
develop
hybrid
shell,
which
further
camouflages
around
drug-loaded
liposome
fabricate
biomimetic
(AB@LRM)
precise
therapy.
Specifically,
photoactive
agent
black
phosphorus
quantum
dots
(BPQDs)
classical
antibiotics
amikacin
(AM)
are
loaded
in
AB@LRM
accurately
target
inflammatory
sites
through
guidance
long
residence
capability
membrane,
eventually
exerting
efficacious
activities.
Besides,
due
excellent
photothermal
photodynamic
properties,
BPQDs
act
as
an
efficient
when
exposed
near-infrared
laser
irradiation,
dramatically
increasing
sensitivity
bacteria
antibiotics.
Consequently,
synergistic
sterilizing
effect
produced
by
restricts
resistance.
Upon
shows
superior
anti-inflammatory
properties
models
P.
aeruginosa-infected
pneumonia
wounds.
Hence,
this
light-activatable
nanoplatform
good
biocompatibility
presents
advance
clinical
development
Язык: Английский
Nanocarrier-Based Transdermal Drug Delivery Systems for Dermatological Therapy
Pharmaceutics,
Год журнала:
2024,
Номер
16(11), С. 1384 - 1384
Опубликована: Окт. 28, 2024
Dermatoses
are
among
the
most
prevalent
non-fatal
conditions
worldwide.
Given
this
context,
it
is
imperative
to
introduce
safe
and
effective
dermatological
treatments
address
diverse
needs
concerns
of
individuals.
Transdermal
delivery
technology
offers
a
promising
alternative
compared
traditional
administration
methods
such
as
oral
or
injection
routes.
Therefore,
review
focuses
on
recent
achievements
nanocarrier-based
transdermal
for
therapy,
which
summarizes
strategies
enhance
skin
penetration
using
various
nanocarriers
including
vesicular
nanocarriers,
lipid-based
emulsion-based
polymeric
nanocarrier
according
pathogenesis
common
dermatoses.
The
fundamentals
physiology
structure
routes
introduced.
Moreover,
mechanisms
due
utilization
hydration,
system
deformability,
disruption
stratum
corneum,
surface
charge,
tunable
particle
size
outlined
well.
Язык: Английский
Electrostatically Stabilized Light-Activated Membrane Delivery System: Overcoming Membrane Flexibility and Self-Repair to Enhance Tumor Therapy
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Cell
membrane-coated
nanoparticle-based
delivery
systems
often
struggle
with
inevitable
drug
leakage
during
the
process
and
inefficient
release
at
tumor
site,
resulting
in
unsatisfactory
antitumor
outcomes.
Here,
we
present
an
electrostatically
stabilized
light-activated
membrane
system
(Hybrid
nanoparticles,
[Hm]@NPs)
for
leak-free
delivery,
coupled
precisely
site-specific
controllable
release,
to
elevate
cancer
treatment.
[Hm]@NPs
are
constructed
by
encapsulating
aggregation-induced
emission
(AIE)
photosensitizer
(Phenalen-1-one-quinoline
malonitrile-thiophene
tribenamine,
Phe-Qui-T)
into
a
positively
charged
reactive
oxygen
species
(ROS)-responsive
polymer
(F127-TP-U11)
form
nanoparticle
then
coating
it
negatively
hybrid
containing
red
blood
cell
Panc-1
membrane.
high
stability
effectively
prevent
through
electrostatic
interaction
between
nanoparticle.
Simultaneously,
Phe-Qui-T
light-controlled
ROS
generation
efficiently
destroys
both
ROS-responsive
membrane,
ensuring
precise
sufficient
while
enabling
photodynamic
therapy
(PDT),
thereby
augmenting
efficacy.
show
impressive
inhibition
pancreatic
mouse
models,
highlighting
potential
of
this
membrane-disruption
strategy
advanced
nanodelivery
design.
Язык: Английский
A Nano-Strategy for Advanced Triple-Negative Breast Cancer Therapy by Regulating Intratumoral Microbiota
Nano Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
Intratumoral
microbiota
have
been
identified
as
a
component
of
the
tumor
microenvironment
that
regulates
metastatic
behavior
tumors.
They
serve
not
only
indicators
pathology
but
also
potential
drug
targets
in
cancer
therapy.
Herein,
multifunctional
nanoplatform
(DD@FEL)
is
prepared
by
combining
antibiotic
doxycycline
(DOXY)
can
combat
intratumoral
and
chemotherapeutic
doxorubicin
(DOX)
ergosterol-originated
liposome.
Specially,
ergosterol
utilized
substitute
for
cholesterol
liposomes
to
exert
pharmacological
activity.
Mechanistically,
DD@FEL
leveraged
DOXY
inhibit
metastasis
based
on
regulation
microbiota,
which
synergizes
with
effect
DOX,
eventually
inhibiting
progression
triple-negative
breast
(TNBC).
Verified
both
vitro
vivo,
effectively
exerts
cytotoxic
TNBC
cells,
delays
growth
primary
TNBC,
attenuates
development
its
lung
metastasis,
providing
promising
therapeutic
strategy
control
orthotopic
TNBC.
Язык: Английский
Tumor Antigen-Coated Two-Dimensional Black Phosphorus as a Nanovaccine for Synergistic Cancer Photothermal Therapy and Immunotherapy
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 4, 2025
Vaccine
immunotherapy
is
paving
the
way
for
an
effective
long-term
immune
response
and
targeted
destruction
of
tumor
cells
shows
promise
as
a
leading
strategy
in
treatment.
Nanoparticles
are
crucial
combining
vaccine
photothermal
therapy
(PTT),
generating
local
thermal
ablation,
triggering
powerful
antitumor
that
inhibits
recurrence.
In
this
study,
we
designed
nanovaccine
combined
PTT
tumors
using
two-dimensional
black
phosphorus
(BP)
nanoplatform
was
modified
with
maleimide
poly(ethylene
glycol)
(PEG-MAL)
coated
antigen
proteins
(BP-PEG-MAL@antigen).
The
BP-PEG-MAL@antigen
nanovaccines
displayed
outstanding
stability
biocompatibility
due
to
comodification
PEG
proteins.
induced
strong
responses
vitro
vivo
effectively
inhibited
orthotopic
bilateral
growth,
prolonged
survival
time,
improved
rate
mice.
addition,
generated
Язык: Английский
Developing Cell-Membrane-Associated Liposomes for Liver Diseases
Dongxue Ge,
Ran An,
Lingling Xue
и другие.
ACS Nano,
Год журнала:
2024,
Номер
18(43), С. 29421 - 29438
Опубликована: Окт. 15, 2024
Over
the
past
decade,
a
marked
escalation
in
prevalence
of
hepatic
pathologies
has
been
observed,
adversely
impacting
quality
life
for
many.
The
predominant
therapeutic
strategy
liver
diseases
pharmacological
intervention;
however,
its
efficacy
is
often
constrained.
Currently,
liposomes
are
tiny
structures
that
can
deliver
drugs
directly
to
targeted
areas,
enhancing
their
effectiveness.
Specifically,
cell
membrane-associated
have
gained
significant
attention.
Despite
this,
there
still
much
learn
about
binding
mechanism
this
type
liposome.
Thus,
review
comprehensively
summarizes
relevant
information
on
liposomes,
including
clinical
applications
and
future
development
directions.
First,
we
will
briefly
introduce
composition
types
liposomes.
We
provide
an
overview
structure
discuss
various
associated
with
membranes.
Second,
thoroughly
strategies
drug
delivery
using
these
Lastly,
application
challenges
treating
diseases.
explore
potential
benefits
while
also
addressing
obstacles
need
be
overcome.
Furthermore,
prospects
field.
In
summary,
underscores
promise
disease
treatment
highlights
further
research
optimize
utilization.
Язык: Английский