Glutamatergic projections from the basolateral amygdala to medial prefrontal cortex contribute to acute itch sensation processing

Journal of Investigative Dermatology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

The parietal association cortex and its projections to the dorsal striatum are involved in histaminergic and nonhistaminergic itch processing

Brain Research Bulletin, Год журнала: 2025, Номер unknown, С. 111352 - 111352

Опубликована: Апрель 1, 2025

Itch is an unpleasant sensation accompanied by the urge to scratch. The act of scratching not only alleviates itch but also activates reward circuitry, inducing a pleasurable that can perpetuate further scratching. Therefore, be characterized as both goal-directed behavior and reward-motivated behavior. As key hub for sensorymotor integration information processing in tasks, specific role posterior parietal cortex (PPC) modulating remains elucidated. Using immunofluorescence calcium-signal fiber photometric recordings, we found neurons association (PtA), subregion PPC, were activated during acute itch. Pharmacogenetic experiments demonstrated nonselective inhibition PtA selective pyramidal neuron activity reduced experimental itch-scratching induced subcutaneous injections 5-HT compound 48/80. projects dorsal striatum (DS), critical component brain's this pathway diminished study first time may involved regulation histaminergic nonhistaminergic through projections DS.

Язык: Английский

Different subregions of the anterior cingulate cortex differentially regulate acute itch-scratching behavior in rats

Behavioural Brain Research, Год журнала: 2025, Номер unknown, С. 115616 - 115616

Опубликована: Май 1, 2025

Язык: Английский