Nano Today, Год журнала: 2024, Номер 61, С. 102588 - 102588
Опубликована: Дек. 6, 2024
Язык: Английский
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Июль 8, 2024
Periodontitis, a prevalent chronic inflammatory disease, poses significant challenges for effective treatment due to its complex etiology involving specific bacteria and the immune microenvironment. Here, this study presents novel approach targeted of periodontitis utilizing immunomodulatory antibacterial properties Embelin, plant-derived compound, within an injectable hydrogel system. The developed Carboxymethyl Chitosan-Oxidized Dextran (CMCS-OD) formed via dynamic chemical bonds exhibited self-healing capabilities pH-responsive behavior, thereby facilitating controlled release Embelin enhancing efficacy in oral This demonstrates that system effectively prevents bacterial invasion mitigates excessive response activation. Moreover, it precisely modulates macrophage M1/M2 phenotypes suppresses cytokine expression, fostering conducive environment bone regeneration addressing periodontitis-induced loss. These findings highlight potential as promising strategy clinical management destruction.
Язык: Английский
Процитировано
11
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 28, 2024
Periodontal disease is a multifactorial, bacterially induced inflammatory disorder characterized by progressive destruction of periodontal tissues. Additionally, diabetes mellitus exacerbates periodontitis, resulting in expedited resorption bone. However, methods such as mechanical debridement, anti-inflammatory medications, and surgical approaches often fail to eradicate local infections inflammation, complicating the reconstruction tissue structures. Consequently, there an urgent need devise novel strategy for managing diabetic conditions. Here, multifunctional controlled-release drug delivery system (GOE1) developed encapsulating self-assembled nanoparticles (consisting chlorhexidine acetate epigallocatechin-3-gallate) into hydrogel matrix composed gelatin methacryloyl oxidized hyaluronic acid. In vitro experiments demonstrate that GOE1 possesses good antimicrobial, antioxidant properties, transgenic sequence genomics further illustrates IL-17-producing RAW 264.7 macrophages are critical mediating M1/M2 macrophage transition provide favorable immune microenvironment. addition, vivo reveal significantly ameliorates inflammation reduces loss alveolar bone reducing infiltration collagen destruction. Overall, offers promising therapeutic option periodontitis.
Язык: Английский
Процитировано
4
Frontiers in Pharmacology, Год журнала: 2025, Номер 15
Опубликована: Янв. 6, 2025
Periodontitis is a chronic inflammatory condition driven by plaque-associated microorganisms, where uncontrolled bacterial invasion and proliferation impair host immune responses, leading to localized periodontal tissue inflammation bone destruction. Conventional therapies face challenges, including incomplete microbial clearance the rise of antibiotic resistance, limiting their precision effectiveness in managing periodontitis. Recently, nanotherapies based on polymeric materials have introduced advanced approaches antimicrobial therapy through diverse mechanisms. This review explored specific mechanisms, emphasizing design polymer-based agents that employ individual or synergistic actions, evaluated innovations limitations current strategies while forecasting future trends development for
Язык: Английский
Процитировано
0
Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 12
Опубликована: Янв. 10, 2025
Bacterial infection, a complex wound microenvironment, and persistent inflammatory response in acute wounds can result delayed healing abnormal scar formation, thereby compromising the normal function aesthetic appearance of skin tissue. This issue represents one most challenging problems clinical practice. study aims to develop hydrogel dressing specifically designed for treatment wounds, providing immediate effective protection affected areas. innovation seeks offer novel advanced solution management wounds. In this study, composite scaffold was synthesized through reaction between oxidized glycyrrhizic acid carboxymethyl chitosan Schiff base. The material properties were systematically characterized, its biocompatibility antibacterial efficacy rigorously evaluated. A rat model established compare multiple groups, assessing impact on microenvironment repair. results demonstrated that OGA-CMCS exhibited excellent injectability, biocompatibility, properties. It capable enhancing which turn influenced polarization macrophages from M1 M2 phenotype, mitigating response, promoting angiogenesis granulation tissue regeneration, accelerating healing. successfully developed glycyrrhizin-based dressing, not only introduces innovative approaches emergency surface defects but also provides an experimental foundation. is anticipated contribute significantly addressing relevant challenges.
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 28, 2025
Abstract Periodontitis is an increasingly prevalent oral inflammatory disease, whose treatment faces potent challenges because of recurrent bacterial infections, excessive reactive oxygen species (ROS) production, as well unrelenting inflammation‐induced alveolar bone resorption during the pathological process. Herein, we present rational design and construction a multifunctional hydrogel platform composed quaternized chitosan/oxidized dextran (QCS/OD) component with high bactericidal activity immunomodulatory carbonized polymer dots from resveratrol (RSV‐CPDs) for periodontitis treatment. Such RSV‐CPDs@QCS/OD (RCQD) hydrogels exhibit characteristics including shape adaptability, self‐healing properties, pH‐responsibility, enabling it to adapt irregularly shaped periodontal tissues, degrade gradually in mildly acidic microenvironment periodontitis, release RSV‐CPDs controlled manner. Significantly, RCQD can effectively suppress proliferation bacteria alleviate oxidative stress, relieve inflammation via activating Nrf2/NF‐κB signaling pathway, ultimately fostering favorable environment regeneration both soft hard tissue. Overall, this study highlights great potential treating by addressing practical needs tissue regeneration.
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Март 12, 2025
Periodontitis, a chronic inflammatory disease caused by bacteria, is characterized localized reactive oxygen species (ROS) accumulation, leading to an response, which in turn leads the destruction of periodontal supporting tissues. Therefore, antibacterial, scavenging ROS, reducing regulating microenvironment, and alleviating alveolar bone resorption are effective methods treat periodontitis. In this study, we developed ROS-responsive injectable hydrogel modifying hyaluronic acid with 3-amino phenylboronic (PBA) reacting it poly(vinyl alcohol) (PVA) form borate bond. addition, encapsulated antibacterial agent minocycline hydrochloride (MH) Fe-Quercetin anti-inflammatory nanoparticles (Fe-Que NPs) for on-demand drug release response periodontitis microenvironment. This (HP-PVA@MH/Fe-Que) exhibited highly properties. Moreover, modulating Nrf2/NF-κB pathway, effectively eliminated ROS promoted macrophage polarization M2 phenotype, inflammation enhancing osteogenic differentiation potential human ligament stem cells (hPDLSCs) Animal studies showed that HP-PVA@MH/Fe-Que significantly reduced loss enhanced factor expression killing bacteria inhibiting inflammation. Thus, had efficient ROS-scavenging, anti-inflammatory, resorption-alleviation abilities, showing excellent application healing.
Язык: Английский
Процитировано
0
Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 251, С. 114604 - 114604
Опубликована: Март 5, 2025
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 4, 2025
Abstract Advanced periodontitis initiates with Porphyromonas gingivalis ( P. ) infection, which subsequently triggers chronic inflammation, immune imbalance, and ultimately causes alveolar bone resorption. Traditional periodontal treatment focuses on the elimination of triggering factors, but tend to ignore improvement inflammatory microenvironment remodeling osteogenic mineralization space. Herein, zinc‐aluminum layered double hydroxide nanosheets (LDHs) loaded icariin (ICA) are encapsulated into a gallic acid (GA)‐modified hydroxybutyl chitosan hydrogel (GA‐HBC), giving rise customized system named GA‐HBC‐LIC, can sequentially actualize antibacterial, anti‐inflammatory, remineralization functions. A neutral chemical‐humoral space is created for osteogenesis via means sequential regulation by smart hydrogel. Concomitantly, appropriate mechanical properties degradation performance provide desirable physical remineralization. In spatiotemporal modulation hydrogel, zinc finger E‐box‐binding homeobox 1 (ZEB1) target released ions (Zn 2+ action promotes macrophage polarization from M1 M2 phenotype, thereby releasing cytokines conducive tissue regeneration. sum, this study highlights critical role inflammation maintenance in regeneration tissues, offering new insights clinical management periodontitis.
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 527 - 527
Опубликована: Апрель 17, 2025
Background: Vulvar vaginal candidiasis (VVC) is a type of vaginitis resulting from Candida infection the mucosa. Traditional treatments using antibiotics often lead to resistance and disrupt microenvironment, causing ongoing problems for patients. In response these challenges, this study introduces multifunctional intelligent responsive probiotic hydrogel designed modulate microecological environment combat albicans infection. Methods: The innovative CMCS-OHA-Lp/Lr was formulated oxidized hyaluronic acid (OHA) carboxymethyl chitosan (CMCS) as carriers, incorporating Lactobacillus plantarum (Lp) rhamnosus (Lr) active components. Comprehensive characterization revealed its chemical structure, rheological properties, rapid self-healing gel degradation, release lactobacilli in vitro. Results: findings demonstrated that hydrogel’s cross-linking conferred significant physical properties. addition, vitro showed cumulative rates Lp Lr medium with pH 5.5 were 83.50 ± 2.70% 73.31 2.22%, which proved pH-responsive characteristics probiotics acidic environments. Furthermore, storage activity indicated survival CMCS-OHA-Lp CMCS-OHA-Lr hydrogels 86.90 0.20% 85.50 0.56%, respectively, proving encapsulation within significantly enhanced stability probiotics. vivo studies further confirmed alleviated vulval edema symptoms reduced C. colonies vagina, thereby mitigating inflammation. Conclusions: conclusion, pH-responsive, self-healing, shear-thinning offers promising approach clinical treatment VVC serves an effective delivery vehicle.
Язык: Английский
Процитировано
0
AAPS PharmSciTech, Год журнала: 2024, Номер 25(8)
Опубликована: Окт. 21, 2024
Язык: Английский
Процитировано
0