Advancements in 3D In Vitro Models for Colorectal Cancer

Advanced Science, Год журнала: 2024, Номер 11(32)

Опубликована: Июль 4, 2024

Abstract The process of drug discovery and pre‐clinical testing is currently inefficient, expensive, time‐consuming. Most importantly, the success rate unsatisfactory, as only a small percentage tested drugs are made available to oncological patients. This largely due lack reliable models that accurately predict efficacy safety. Even animal often fail replicate human‐specific pathologies human body's complexity. These factors, along with ethical concerns regarding use, urge development suitable human‐relevant, translational in vitro models.

Язык: Английский

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Host-microbe-cancer interactions on-a-chip

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Март 31, 2025

The tumor microbiota has emerged as a pivotal contributor to variety of cancers, impacting disease development, progression, and therapeutic resistance. Due the complexity microenvironment, reproducing interactions between microbes, cells, immune system remains great challenge for both in vitro vivo studies. To this end, significant progress been made toward leveraging tumor-on-a-chip model systems replicate critical hallmarks native vitro. These microfluidic platforms offer ability mimic essential components including controllable fluid flow conditions, manipulable extracellular matrix dynamics, intricate 3D multi-cellular communication. primary objective review is discuss recent challenges advances engineering host-microbiota on-a-chip. Ultimately, overcoming these obstacles will help us gain deeper insights into tumor-microbe enhance avenues developing more effective cancer therapies.

Язык: Английский

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Development of Liver Cancer Organoids: Reproducing Tumor Microenvironment and Advancing Research for Liver Cancer Treatment

Technology in Cancer Research & Treatment, Год журнала: 2024, Номер 23

Опубликована: Янв. 1, 2024

Liver cancer a leading cause of cancer-related deaths worldwide, yet understanding its development mechanism remains limited, and treatment barriers present substantial challenges. Owing to the heterogeneity tumors, traditional 2D culture models are inadequate for capturing complexity diversity tumor biology disease. Organoids have garnered considerable attention because their ability self-renew develop functional structures in vitro that closely resemble those human organs. This review explores history liver organoids, cellular origins, techniques constructing microenvironments recapitulate biological clinical applications organoids current challenges related organoid potentially valuable solutions, with aim facilitating construction therapeutic research.

Язык: Английский

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A 3D bioprinted potential colorectal tumor model based on decellularized matrix/gelatin methacryloyl/nanoclay/sodium alginate hydrogel

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 293, С. 139346 - 139346

Опубликована: Дек. 30, 2024

Язык: Английский

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