Microorganisms,
Год журнала:
2024,
Номер
12(11), С. 2362 - 2362
Опубликована: Ноя. 19, 2024
Chronic
wounds
are
often
caused
or
exacerbated
by
microbial
biofilms
that
highly
resistant
to
antimicrobial
treatments
and
prevent
healing.
This
study
compared
the
antibiofilm
activity
of
nine
topical
wound
treatments,
comprising
gels
with
different
concentrations
poloxamer
407
(20-26%)
pH
levels
(4-6)
containing
polyhexanide
(PHMB)
as
an
agent;
effects
on
this
agent
have
not
been
previously
reported.
The
gel
formulations
were
tested
against
six
common
wound-associated
pathogens:
Abstract
Oral
ulcers
can
be
addressed
using
various
biomaterials
designed
to
deliver
medications
or
cytokines.
Nevertheless,
the
effectiveness
of
these
substances
is
frequently
limited
in
many
patients
due
poor
adherence,
short
retention
time
mouth,
and
less‐than‐optimal
drug
efficacy.
In
this
study,
a
new
hydrogel
patch
(FSH3)
made
silk
fibroin/hyaluronic
acid
matrix
with
light‐sensitive
adhesive
qualities
infused
ferric
iron/shikonin
nanoparticles
enhance
healing
effects
presented.
Initially,
forms
an
barrier
over
mucosal
lesions
through
straightforward
local
injection,
solidifying
when
exposed
UV
light.
Subsequently,
FSH3
demonstrates
superior
reactive
oxygen
species
elimination
near‐infrared
photothermal
bactericidal
activity.
These
characteristics
support
bacterial
regulate
oxidative
levels,
promoting
wound's
progression
from
inflammation
tissue
regeneration.
diabetic
rat
model
mimicking
oral
ulcers,
significantly
speeds
up
by
adjusting
inflammatory
environment
injured
tissue,
maintaining
balance
microbiota,
faster
re‐epithelialization.
Overall,
shows
potential
for
rapid
wound
recovery
may
transform
therapeutic
methods
managing
diabetes.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 4, 2025
Abstract
Advanced
periodontitis
initiates
with
Porphyromonas
gingivalis
(
P.
)
infection,
which
subsequently
triggers
chronic
inflammation,
immune
imbalance,
and
ultimately
causes
alveolar
bone
resorption.
Traditional
periodontal
treatment
focuses
on
the
elimination
of
triggering
factors,
but
tend
to
ignore
improvement
inflammatory
microenvironment
remodeling
osteogenic
mineralization
space.
Herein,
zinc‐aluminum
layered
double
hydroxide
nanosheets
(LDHs)
loaded
icariin
(ICA)
are
encapsulated
into
a
gallic
acid
(GA)‐modified
hydroxybutyl
chitosan
hydrogel
(GA‐HBC),
giving
rise
customized
system
named
GA‐HBC‐LIC,
can
sequentially
actualize
antibacterial,
anti‐inflammatory,
remineralization
functions.
A
neutral
chemical‐humoral
space
is
created
for
osteogenesis
via
means
sequential
regulation
by
smart
hydrogel.
Concomitantly,
appropriate
mechanical
properties
degradation
performance
provide
desirable
physical
remineralization.
In
spatiotemporal
modulation
hydrogel,
zinc
finger
E‐box‐binding
homeobox
1
(ZEB1)
target
released
ions
(Zn
2+
action
promotes
macrophage
polarization
from
M1
M2
phenotype,
thereby
releasing
cytokines
conducive
tissue
regeneration.
sum,
this
study
highlights
critical
role
inflammation
maintenance
in
regeneration
tissues,
offering
new
insights
clinical
management
periodontitis.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
Abstract
Well‐integration
of
multiple
bioactive
components
into
a
biological
patch
without
damaging
its
cellular
matrix
structure
is
crucial
for
infectious
abdominal
wall
defect
repair
but
remains
challenging.
Herein,
novel
asymmetric
composite
(bPVA/SIS
+
‐NP)
developed
by
in
situ
introducing
zwitterionic
polyvinyl
alcohol
molecular
brush
(bPVA)
hydrogel
to
cationic
small
intestinal
submucosal
decellularized
(SIS
)
via
self‐induced
phase
separation
based
united
strategy.
Due
high
hydrogen
bonding
crosslinking
and
strong
mechanical
interlocking
with
SIS
‐NP
layer,
bPVA
layer
can
maintain
stable
anti‐contamination
the
corresponding
anti‐adhesion
properties
contaminated
environment.
On
basis
preserving
an
original
extracellular
skeleton,
show
contact
anti‐bacterial
ability
at
acute
stage
together
prolonged
drug
release
during
healing
repair.
Furthermore,
combination
layers
lead
burst
pressure
tolerance.
By
comprehensive
control
bacteria
their
necrotic
products,
bPVA/SIS
achieve
anti‐infection,
anti‐adhesion,
pro‐healing
on
rats.
Therefore,
opens
new
avenue
bio‐friendly
construction
multifunctional
patches
address
stringent
requirements
