Neutrophil‐Targeting Semiconducting Polymer Nanotheranostics for NIR‐II Fluorescence Imaging‐Guided Photothermal‐NO‐Immunotherapy of Orthotopic Glioblastoma
Advanced Science,
Год журнала:
2024,
Номер
11(39)
Опубликована: Авг. 19, 2024
Abstract
Glioblastoma
(GBM)
is
one
of
the
deadliest
primary
brain
tumors,
but
its
diagnosis
and
curative
therapy
still
remain
a
big
challenge.
Herein,
neutrophil‐targeting
semiconducting
polymer
nanotheranostics
(SSPN
iNO
)
reported
for
second
near‐infrared
(NIR‐II)
fluorescence
imaging‐guided
trimodal
orthotopic
glioblastoma
in
mouse
models.
The
SSPN
are
formed
based
on
two
polymers
acting
as
NIR‐II
probe
well
photothermal
conversion
agent,
respectively.
A
thermal‐responsive
nitric
oxide
(NO)
donor
an
adenosine
2A
receptor
(A2AR)
inhibitor
co‐integrated
into
to
enable
therapeutic
actions.
surface
attached
with
ligand
mediate
their
effective
delivery
GBM
sites
via
“Trojan
Horse”
manner,
enabling
high‐sensitive
imaging.
Upon
light
illumination,
effectively
generates
heat
effect,
which
not
only
kills
tumor
cells
induces
immunogenic
cell
death
(ICD),
also
triggers
controlled
NO
release
strengthen
ICD.
Additionally,
encapsulated
A2AR
can
modulate
immunosuppressive
microenvironment
by
blocking
adenosine‐A2AR
pathway,
further
boosts
antitumor
immunological
effect
observably
suppress
progression.
This
study
provide
multifunctional
theranostic
nanoplatform
cumulative
actions
treatment.
Язык: Английский
Advancing brain immunotherapy through functional nanomaterials
Drug Delivery and Translational Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
Abstract
Glioblastoma
(GBM),
a
highly
aggressive
brain
tumor,
poses
significant
treatment
challenges
due
to
its
immunosuppressive
microenvironment
and
the
immune
privilege.
Immunotherapy
activating
system
T
lymphocyte
infiltration
holds
great
promise
against
GBM.
However,
brain’s
low
immunogenicity
difficulty
of
crossing
blood-brain
barrier
(BBB)
hinder
therapeutic
efficacy.
Recent
advancements
in
immune-actuated
particles
for
targeted
drug
delivery
have
shown
potential
overcome
these
obstacles.
These
interact
with
BBB
by
rapidly
reversibly
disrupting
structure,
thereby
significantly
enhancing
targeting
penetrating
delivery.
The
also
minimizes
long-term
damage.
At
GBM,
demonstrated
effective
chemotherapy,
chemodynamic
therapy,
photothermal
therapy
(PTT),
photodynamic
(PDT),
radiotherapy,
or
magnetotherapy,
facilitating
tumor
disruption
promoting
antigen
release.
Additionally,
components
retained
autologous
tumor-associated
antigens
presented
them
dendritic
cells
(DCs),
ensuring
prolonged
activation.
This
review
explores
mechanisms
existing
strategies,
role
nanomaterials
immunotherapy.
We
discuss
innovative
particle-based
approaches
designed
traverse
mimicking
innate
functions
improve
outcomes
tumors.
Graphical
Язык: Английский
Novel neutrophil targeting platforms in treating Glioblastoma: Latest evidence and therapeutic approaches
International Immunopharmacology,
Год журнала:
2025,
Номер
150, С. 114173 - 114173
Опубликована: Фев. 11, 2025
Язык: Английский
GSH‐Responsive Semiconducting Polymer as a Nanotheranostic Platform for NIR‐II Imaging‐Guided Chemo‐Photothermal Therapy
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 22, 2025
Abstract
The
development
of
multifunctional
nanotheranostic
platforms
with
stimuli‐responsive
capabilities
holds
significant
potential
for
enhancing
cancer
diagnosis
and
treatment.
Herein,
a
glutathione
(GSH)‐responsive
semiconducting
polymer
(SP)
system,
SP/DOX‐SS‐PEG
nanoparticles
(NPs),
is
presented,
designed
combined
near‐infrared
II
(NIR‐II)
fluorescence
imaging
(FI)
chemo‐photothermal
therapy.
amphiphilic
SP
(SP‐SS‐PEG)
synthesized
through
multi‐step
reaction
sequence,
including
Suzuki
coupling,
amidation,
thiol‐disulfide
exchange
reactions,
subsequently
encapsulates
the
anticancer
drug
doxorubicin
(DOX)
self‐assembly,
resulting
in
formation
GSH‐responsive
NPs.
These
NPs
exhibit
high
photothermal
stability
GSH‐triggered
DOX
release.
In
vitro
studies
demonstrate
that
display
enhanced
cellular
uptake
robust
cytotoxicity
against
4T1
cells
under
808
nm
laser
irradiation.
Upon
intravenous
injection
tumor‐bearing
mice,
NIR‐II
FI
reveals
efficient
tumor
accumulation
prolonged
retention
vivo
anti‐tumor
efficacy
indicate
irradiation
achieve
most
inhibition
growth,
minimal
systemic
toxicity.
Taken
together,
these
findings
highlight
promising
as
platform
precision
theranostics,
integrating
imaging,
release,
dual
Язык: Английский
Selective Photothermal Eradication of Glioblastoma Cells Coexisting with Astrocytes by Anti-EGFR-Coated Raman Tags
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 18, 2025
Glioblastoma
(GBM)
is
an
aggressive
and
fatal
tumor.
The
infiltrative
spread
of
GBM
cells
hinders
gross
total
resection.
residual
are
significantly
associated
with
survival
recurrence.
Therefore,
a
theranostic
method
that
can
enhance
the
contrast
between
normal
astrocyte
(AS)
selectively
eradicate
highly
desired.
In
this
report,
both
cultured
in
same
microplate
well
to
imitate
coexistence
environment
treated
Raman
tags
functionalized
by
anti-EGFR.
Compared
AS
cells,
show
25%
higher
emission,
their
cell
death
rate
increases
factor
2.
These
results
demonstrate
potential
for
selective
eradication
guided
robust
signals
after
primary
surgery.
Язык: Английский
Hierarchical Targeting Nanoplatform for NIR‐II Photoacoustic Imaging and Photo‐Activated Synergistic Immunotherapy of Glioblastoma
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Abstract
Glioblastoma
(GBM)
stands
as
the
most
aggressive
malignant
brain
tumor,
characterized
by
poor
prognosis,
high
recurrence
rate,
and
resistance
to
multiple
therapies,
posing
a
significant
clinical
challenge.
Here,
hierarchical
targeting
platform
is
presented
for
NIR‐II
photoacoustic
(PA)
imaging‐guided
photo‐chemo
synergistic
immunotherapy
of
GBM.
A
new
molecular
probe
developed
with
exceptional
light‐harvesting
capabilities
enhanced
motion,
boosting
both
photothermal
conversion
PA
signal.
This
probe,
combined
thermo‐responsive
prodrug,
assembled
into
nanoparticles
that
are
further
camouflaged
tumor
cell
membranes
bioorthogonally
modified
transferrin‐mimicking
peptide,
facilitating
blood‐brain
barrier
penetration
GBM
targeting.
High‐contrast
imaging
allows
precise
detection
delineation
GBM,
providing
accurate
guidance
subsequent
treatment.
The
light‐triggered
effect,
coupled
hyperthermia‐activated
significantly
induces
immunogenic
death,
enhancing
tumor‐killing
efficiency
amplifying
anti‐tumor
immune
response.
self‐synergistic
not
only
stimulates
robust
immunity
inhibits
primary
growth
but
also
prevents
post‐surgical
recurrence,
prolonging
survival
time.
work
exemplifies
novel
paradigm
tackling
diagnostic
therapeutic
challenges
posed
deeply
seated
poorly
tumors.
Язык: Английский
A Porphyrin Nanomaterial for Photoimmunotherapy for Treatment of Melanoma
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Abstract
The
incidence
of
melanoma,
the
third
most
common
skin
cancer,
has
been
on
rise
in
recent
years.
In
addition,
it
a
high
mortality
rate
due
to
its
aggressiveness.
Phototherapy,
as
promising
treatment
method,
can
effectively
kill
tumor
cells,
but
is
incapable
metastasis.
Herein,
nanomaterial
(TPC@OVA
NPs)
developed
for
phototherapy
conjunction
with
immunotherapy
against
melanoma.
TPC,
derivative
porphyrin,
used
photosensitizer
excellent
biosafety
and
photostability.
After
assembly
ovalbumin
(OVA),
TPC@OVA
NPs
vaccine
properties
formed,
which
not
only
ablate
primary
also
induce
immunogenic
cell
death
(ICD).
DC
cells
be
stimulated
mature
by
exogenous
OVA,
enhancing
immune
response
tumors
further
activating
T
lymphocytes.
Combined
checkpoint
inhibitor
aPD‐1,
microenvironment
reshaped,
increased
activity
are
validated.
This
work
highlights
potential
combining
Язык: Английский
Breast Cancer Bone Metastasis Therapy and Tumor‐Associated Bone Destruction Repair by Versatile Semiconducting Nanointegrators with X‐Ray Adjuvant
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 6, 2024
Abstract
Tumor
progress
and
tumor‐associated
osteolysis
are
two
key
issues
of
breast
cancer
bone
metastasis,
which
makes
it
challenging
for
metastasis
treatment.
To
settle
these
concurrently,
a
versatile
semiconducting
nanointegrator
(termed
as
SPN
CpG/Ca
)
containing
polymer
nanoparticle
(SPN),
Ca
2+
cytosine‐phosphate‐guanine
(CpG)
oligonucleotides
conjugated
on
the
surface
via
singlet
oxygen
(
1
O
2
)‐responsive
linker,
is
designed.
The
antitumor
effect
can
be
triggered
with
X‐ray
irradiation
an
adjuvant,
in
works
radiosensitizer
to
produce
radiotherapy
controlled
release
CpG
disrupting
‐responsive
linkers.
accumulation
delivering
causes
tumor
cell
death
released
activates
immune
response
realize
immunotherapy.
combinational
action
radiotherapy,
overloading,
immunotherapy
results
complete
clearance
metastatic
cells
4T1
cancer‐based
mouse
models.
Furthermore,
accelerate
osteogenesis
marrow
mesenchymal
stem
while
inhibits
osteoclast
differentiation
microenvironment
alleviate
osteolysis,
synergistically
contributes
repair
destruction.
represents
therapeutic
nanosystem
abilities
treat
destruction,
providing
new
tactic
therapy.
Язык: Английский
Advances in Photothermal and Photodynamic Nanotheranostics for Precision Cancer Treatment
Journal of Nanotheranostics,
Год журнала:
2024,
Номер
5(4), С. 228 - 252
Опубликована: Дек. 13, 2024
Nanotheranostics,
combining
photothermal
therapy
(PTT)
and
photodynamic
(PDT),
can
transform
precision
cancer
treatment
by
integrating
diagnosis
into
a
single
platform.
This
review
highlights
recent
advances
in
nanomaterials,
drug
delivery
systems,
stimuli-responsive
mechanisms
for
effective
PTT
PDT.
Multifunctional
nanoparticles
enable
targeted
delivery,
multimodal
imaging,
controlled
release,
overcoming
the
challenges
posed
tumor
microenvironments.
Emerging
approaches
such
as
hybrid
therapies
immune
activation
further
enhance
therapeutic
efficacy.
paper
discusses
limitations
of
nanotheranostics,
including
synthesis
complexity
limited
tissue
penetration,
explores
future
directions
toward
biocompatible,
scalable,
clinically
translatable
solutions.
Язык: Английский